Zobrazeno 1 - 10
of 45
pro vyhledávání: '"F M Belpaire"'
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 29(5)
This study in human liver microsomes was undertaken to establish whether paroxetine stereoselectively inhibits the oxidative metabolism of metoprolol in vitro, and whether the in vivo observed magnitude of the paroxetine-metoprolol interaction was pr
Autor:
E A, De Letter, P, De Paepe, K M, Clauwaert, F M, Belpaire, W E, Lambert, J F, Van Bocxlaer, M H, Piette
Publikováno v:
International journal of legal medicine. 114(1-2)
As drug instability and redistribution are factors known to affect the interpretation of post-mortem blood levels, we questioned whether post-mortem vitreous humour concentrations could be useful as predictors for the MDMA load at the time of death.
Publikováno v:
Pharmaceutical research. 16(6)
The effect-plasma concentration relationship of etomidate was studied in the rat using electroencephalographic changes as a pharmacodynamic parameter.Etomidate was infused (50 mg/kg/h) in chronically instrumented rats (n=6) until isoelectric periods
Publikováno v:
Pharmaceutical research. 12(12)
To study the effect of probenecid on the stereoselective pharmacokinetics of oxprenolol and its glucuronides in the rabbit.An oral dose of 50 mg/kg racemic oxprenolol was given to nine rabbits twice, in random sequence with and without the concurrent
Publikováno v:
Journal of pharmaceutical sciences. 81(12)
A liquid chromatographic method for the determination of oxytetracycline in bovine plasma was developed. Contrary to most current tetracycline assays involving solid-phase extraction, oxytetracycline and the internal standard tetracycline were isolat
Autor:
F M, Belpaire, M G, Bogaert
Publikováno v:
International journal of clinical pharmacology, therapy, and toxicology. 29(3)
The variability of the serum binding of the short-acting narcotic analgesic alfentanil was studied. Binding of alfentanil was measured in human alpha 1-acid glycoprotein (AAG) and human albumin solutions, and in serum from 6 groups of individuals: co
Autor:
F M, Belpaire, F, de Smet, L J, Vynckier, A M, Vermeulen, M T, Rosseel, M G, Bogaert, L, Chauvelot-Moachon
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 254(1)
The pharmacokinetics of three beta adrenoceptor blocking drugs atenolol, metoprolol, propranolol and of the model drug antipyrine were studied in 3-, 12- and 24-month-old rats. Alpha-1-acid glycoprotein in plasma was slightly increased and the free f
Publikováno v:
Archives of Toxicology. 43:263-271
Methyl parathion (1, 3, 10 and 30 mg.kg-1) was injected intravenously in dogs and the serum concentrations were followed in function of time. For each dose the serum level data were fitted to a two- or tri-exponential equation by means of a non-linea
Autor:
M. T. Rosseel, F. M. Belpaire
Publikováno v:
Journal of High Resolution Chromatography. 11:103-106
A specific, sensitive, and accurate assay for quantitation of verapamil has been developed. The method involves a single extraction step with n-heptane, followed by evaporation at room temperature under nitrogen. 0.1 μl of the extract was injected i