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Publikováno v:
Anaesthesia and Intensive Care. 25:365-368
A retrospective review was made of 49 survivors who were mechanically ventilated for more than 48 hours in the neurosurgical ICU.Thirty-two patients (Gp I) were successfully extubated, 9 patients (Gp II) underwent tracheostomy after one or more faile
Publikováno v:
Pharmaceutical research. 1(4)
Volume shift during equilibrium dialysis produces errors in estimating the fraction of drug unbound. This study describes a method in which protein concentration in the plasma is used to correct binding data for volume shifts. Data are presented for
Publikováno v:
Methods in molecular medicine. 25
The overall goal of gene therapy is to cure or stabilize a disease process that results from the production of a mutant protein (for example, the chloride channel protein important in cystic fibrosis) or overproduction of a normal protein (such as th
Publikováno v:
The Medical journal of Malaysia. 60(5)
Sinusitis is an important cause of morbidity and one of the major sources of income loss. Anatomical variations of the nose have been reported to predispose to sinusitis. These variations include concha bullosa, nasal septal deviation and oversized b
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 6(6)
Cancers overexpressing Bcl-2 protein, which prevents programmed cell death (apoptosis), are less sensitive to stresses that produce cellular damage, including chemotherapy. If the level of Bcl-2 protein can be reduced sufficiently using antisense oli
Publikováno v:
Journal of pharmaceutical sciences. 89(5)
We evaluated the use of poly(ethylene glycol) (PEG)-modified lipids to control the surface properties of a lipid-based gene transfer system. The lipid-DNA particles (LDPs) used form spontaneously when plasmid DNA is added to mixed detergent lipid mic
Publikováno v:
American Journal of Physiology-Renal Physiology. 253:F141-F150
Experiments were conducted to study the transport of the histamine H2-receptor antagonist, cimetidine, in luminal membrane vesicles prepared from rabbit renal cortex. Cimetidine accumulated in the vesicles with time. Cimetidine uptake was sensitive t
Publikováno v:
Blood. 28:40-53
Neonatally thymectomized hamsters implanted with diffusion envelopes containing thymus showed partial prevention of the effects of thymectomy. A normal humoral antibody response was maintained in these animals, although a significant lymphocytopenia
Publikováno v:
Architectural Science Review. 6:67-81
(1963). The Daylight Factor Concept and the Lumen Method of Daylight Prediction. Architectural Science Review: Vol. 6, No. 2, pp. 67-81.