Zobrazeno 1 - 10
of 16
pro vyhledávání: '"F M, Watt"'
Autor:
M. D. Lynch, C. N. S. Lynch, E. Craythorne, K. Liakath-Ali, R. Mallipeddi, J. N. Barker, F. M. Watt
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Deep sequencing technologies allow for the investigation of clonal evolution in human cancers. Here the authors, combining sequencing data from human skin with mathematical modelling and simulations, suggest that the spatial context of a mutation wit
Externí odkaz:
https://doaj.org/article/0f0d3a09923e4b6eb97e3107824208bf
Autor:
F. M. Watt
Publikováno v:
Animal Models of T Cell-Mediated Skin Diseases ISBN: 9783540210672
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4072518fb377f80bb1788a096a97aa3b
https://doi.org/10.1007/3-540-26811-1_16
https://doi.org/10.1007/3-540-26811-1_16
Autor:
F M, Watt
Publikováno v:
Ernst Schering Research Foundation workshop. (50)
Autor:
D M, Owens, F M, Watt
Publikováno v:
Cancer research. 61(13)
Although aberrant integrin expression has been documented in many epithelial tumors, little is known about how integrins influence neoplastic progression. To examine this issue, transgenic mice in which the alpha2beta1 or alpha3beta1 integrin was exp
Publikováno v:
Experimental dermatology. 9(6)
Involucrin is a protein precursor of the epidermal cornified envelope. Although expression of the human protein has been documented extensively, studies in the mouse have been hampered by a shortage of good antibodies. We describe the production of r
Publikováno v:
The Journal of Cell Biology
Envoplakin and periplakin are two plakins that are precursors of the epidermal cornified envelope. We studied their distribution and interactions by transfection of primary human keratinocytes and other cells. Full-length periplakin localized to desm
Publikováno v:
Journal of cellular biochemistry. 78(1)
Human epidermal keratinocytes are one of the few cell types that express the beta1B splice variant of the beta1 integrin subunit. Although in transfection experiments beta1B acts as a dominant negative inhibitor of cell adhesion, we found that beta1B
Publikováno v:
The Journal of pathology. 186(1)
In addition to their role in maintenance of tissue integrity, cell adhesion molecules regulate the growth and differentiation of stratified squamous epithelia. Reduced expression of E-cadherin and the alpha 2 beta 1, alpha 3 beta 1 and alpha 6 beta 4
Publikováno v:
International journal of cancer. 66(4)
CD44 is a transmembrane glycoprotein that binds hyaluronan, extracellular matrix proteins and growth factors. Multiple isoforms of CD44 are generated by alternative splicing of 10 separate exons (V1-V10). Expression of the variable exons has been cor
Autor:
A, Gandarillas, F M, Watt
Publikováno v:
Oncogene. 11(7)
Normal human epidermal keratinocytes are induced to undergo terminal differentiation when disaggregated and placed in suspension: commitment occurs at about 5 h and overt differentiation by 24 h. In contrast, the squamous cell carcinoma line SCC12B2