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DETERGENTS: FROM PHYSICAL PRINCIPLES TO BIOPHARMACEUTICAL APPLICATIONS (OR WHY WE FIGHT COVID-19 WITH TOILET SOAP)

Autor: A. Alonso, F. M. Goñi

Publikováno v: Anales de la Real Academia Nacional de Farmacia. :53-96

Los detergentes son anfifilos solubles que poseen la capacidad de solubilizar grasas, dando lugar a micelas mixtas lipido-detergente, que son solubles en agua. Los detergentes son ampliamente utilizados en las industrias alimentaria y de bebidas, tex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8295f27a6f9a81a31a9512363295040a
https://doi.org/10.53519/analesranf.2021.87.01.04

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Early stages of LDL oxidation: apolipoprotein B structural changes monitored by infrared spectroscopy

Autor: R, Chehin, D, Rengel, J C, Milicua, F M, Goñi, J L, Arrondo, G, Pifat

Publikováno v: Journal of lipid research. 42(5)

Changes in the conformation of apoliprotein B-100 in the early stages of copper-mediated low density lipoprotein oxidation have been monitored by infrared spectroscopy. During the lag phase no variation in structure is observed, indicating that coppe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dbee798b4dcaf1d289bf032e6d39c969
https://pubmed.ncbi.nlm.nih.gov/11352985

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Compartmentalization of ceramide signaling: physical foundations and biological effects

Autor: R N, Kolesnick, F M, Goñi, A, Alonso

Publikováno v: Journal of cellular physiology. 184(3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1fdb43f11bf751d895347120b53293de
https://pubmed.ncbi.nlm.nih.gov/10911359

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Structure and functional properties of diacylglycerols in membranes

Autor: F M, Goñi, A, Alonso

Publikováno v: Progress in lipid research. 38(1)

1. 1,2-Diacyl-sn-glycerols (DAG) are minor components of cell membranes (about 1 mole% of the lipids) and yet they are potent regulators of both the physical properties of the lipid bilayer and the catalytic behaviour of several membrane-related enzy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dc035caf67117c93f3567353c012c4cc
https://pubmed.ncbi.nlm.nih.gov/10396601

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E. coli alpha-hemolysin: a membrane-active protein toxin

Autor: F M, Goñi, H, Ostolaza

Publikováno v: Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 31(8)

alpha-Hemolysin is synthesized as a 1024-amino acid polypeptide, then intracellularly activated by specific fatty acylation. A second activation step takes place in the extracellular medium through binding of Ca2+ ions. Even in the absence of fatty a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::cd9648469d5df9326834541318f326c7
https://pubmed.ncbi.nlm.nih.gov/9777009

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Biological Amphiphile Systems, and Relevance of Surfactants in the Biomedical Arena, Health, and the Human Body

Autor: W. Bras, M. P. Krafft, A. Bor, E. W. Kaler, J. Mellema, J. P. Rolland, H. E. J. Hofland, M. T. García, S. Jutras, P. Tancréde, K. L. E. Kaiser, E. del Rio, A. Alonso, G. L. Bluestone, K. S. Dhathathreyan, Pierandrea Lo Nostro, M. Chatterjee, J. M. González-Mañas, J. J. González, S. Paredes, C. L. Khetrapal, W. Helfrich, Anne Novelli, B. Kluge, A. Colotto, J. Sanchez, M. Winterhalter, Janusz Pawelek, Melissa Speer, D. N. Misra, R. B. Shireman, K. M. Yu, M. A. Urbaneja, Teresa M. Carvajal, H. Talsma, A. K. Tiwari, Ok-Sup Lee, Jong-Duk Kim, C. C. Liu, F. M. Goñi, A. Dhathathreyan, F. Spies, Y. C. Chiu, P. W. Chun, P. Bosch, V. K. Shahi, F. Comelles, Geeta Datta, M. F. Roberts, D. E. Milov, Maria Polanska, Ralph W. Niven, Armand Lattes, P. Laggner, Hans Schreier, I. Gruda, Sanjay Kumar Singh, D. Meyouchas, H. E. Bodde, M. Postel, Iwona Maciejowska, S. Kalachandra, Ryszard Kurzawa, D. Hoekstra, J. Caelles, K. J. Longmuir, T. A. A. Fonteijn, F. Baumgart, M. A. Partearroyo, G. A. Senisterra, J. B. F. N. Engberts, V. Vodyanoy, L. I. Viera, J. A. Bouwstra, T. L. Lin, G. S. Gooris, C. Ullrich, K. Lohner, E. A. Disalvo, J. B. A. F. Smeulders, Jin-Gu Kim, C. Santaella, Magdalena Hanicka, Kehar Singh, J. Barwicz, P. Vierling, J. Sánchez Leal, J. M. González Mañas, M. A. Long, S. H. Chen, D. Lichtenberg, C. Blom, M. Tribout, P. S. Parvathanathan, H. E. Junginger, J. Vater, M. Wahlgren, D. P. Singh, Lata Sumanan, K. Usha Deniz, T. Arnebrant, D. Ziessow, M. Rubin, S. P. Lee, J. G. Riess, Y. J. L. Parra, P. Nandy, K. V. Ramanathan, Gabriella Gabrielli, Narendra N. Roy, M. Rotenberg, Hak-Hee Kang, Isabelle Rico

Publikováno v: Surfactants in Solution ISBN: 9781461367123

Electron micrographs, dynamic light-scattering, and osmotic measurements have been performed on monolayered vesicles obtained from two bolaform amphiphiles of recent synthesis. Monolayered vesicles of bipolar lipids constitute an interesting model fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1339047fbc959dea1dfa7c88b0bc5503
https://doi.org/10.1007/978-1-4615-3836-3_53

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Surfactant-induced cell toxicity and cell lysis. A study using B16 melanoma cells

Autor: M, Aránzazu Partearroyo, H, Ostolaza, F M, Goñi, E, Barberá-Guillem

Publikováno v: Biochemical pharmacology. 40(6)

The effects of a variety of detergents (non-ionic, ionic and bile derivatives) on B16 melanoma cells have been examined. Two main effects can be clearly differentiated: loss of cell viability and cell lysis. Under our conditions, cell-surfactant inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::965c239657008b6523c391ee04e81a7c
https://pubmed.ncbi.nlm.nih.gov/2403386

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Release of dialkylglycerol from purple membrane phospholipids by phospholipase D

Autor: A, Muga, J L, Arrondo, J I, Gurtubay, F M, Goñi

Publikováno v: The Journal of biological chemistry. 265(11)

When the major polar lipid of purple membrane, a dialkyl analogue of phosphatidyl glycerophosphate, is treated with phospholipase D under the usual assay conditions for this enzyme, the reaction yields dialkylglycerol and glycerol bisphosphate, i.e.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1780b7f3ab05baadcc5276ba57cf6caf
https://pubmed.ncbi.nlm.nih.gov/2108151

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A water-soluble polylysine-retinaldehyde Schiff base. Stability in aqueous and nonaqueous environments

Autor: A R, Viguera, M J, Villa, F M, Goñi

Publikováno v: The Journal of biological chemistry. 265(5)

In order to improve the existing models of retinal-protein Schiff bases, a water-soluble polylysine-retinaldehyde imine has been synthesized and its stability assessed under a variety of conditions through changes in the visible absorption spectrum.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f66a554a7e394538b7952f55198ada6b
https://pubmed.ncbi.nlm.nih.gov/2303414

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