Zobrazeno 1 - 10
of 427
pro vyhledávání: '"F Legler"'
Autor:
Nicolas Garcia-Seyda, Solene Song, Valentine Seveau de Noray, Luc David-Broglio, Christoph Matti, Marc Artinger, Florian Dupuy, Martine Biarnes-Pelicot, Marie-Pierre Valignat, Daniel F. Legler, Marc Bajénoff, Olivier Theodoly
Publikováno v:
iScience, Vol 26, Iss 10, Pp 107695- (2023)
Summary: Naive T lymphocytes traffic through the organism in search for antigen, alternating between blood and secondary lymphoid organs. Lymphocyte homing to lymph nodes relies on CCL21 chemokine sensing by CCR7 receptors, while exit into efferent l
Externí odkaz:
https://doaj.org/article/80cc1697d0144c61ae87a4ccce1aa50b
Autor:
Serena Melgrati, Oliver J. Gerken, Marc Artinger, Egle Radice, Martyna Szpakowska, Andy Chevigné, Giulia D’Uonnolo, Paola Antonello, Sylvia Thelen, Pawel Pelczar, Daniel F. Legler, Marcus Thelen
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Immune responses highly depend on the effective trafficking of immune cells into and within secondary lymphoid organs (SLOs). Atypical chemokine receptors (ACKRs) scavenge chemokines to eliminate them from the extracellular space, thereby generating
Externí odkaz:
https://doaj.org/article/9970cfc4f4c44b67969d20b2bd45a28c
Autor:
Pascal Rossatti, Gregory M. I. Redpath, Luca Ziegler, Guerric P. B. Samson, Camille D. Clamagirand, Daniel F. Legler, Jérémie Rossy
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-21 (2022)
Abstract Background T cell activation leads to increased expression of the receptor for the iron transporter transferrin (TfR) to provide iron required for the cell differentiation and clonal expansion that takes place during the days after encounter
Externí odkaz:
https://doaj.org/article/695de88cfb664dce8346d8d10059d226
Autor:
Martyna Szpakowska, Giulia D’Uonnolo, Rafael Luís, Ana Alonso Bartolomé, Marcus Thelen, Daniel F. Legler, Andy Chevigné
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Atypical chemokine receptors (ACKRs) form a small subfamily of receptors (ACKR1–4) unable to trigger G protein-dependent signaling in response to their ligands. They do, however, play a crucial regulatory role in chemokine biology by capturing, sca
Externí odkaz:
https://doaj.org/article/8e49bcf050c243f79bcc7daea35cb726
Autor:
Elena C Sigmund, Aline Bauer, Barbara D Jakobs, Hazal Tatliadim, Carlotta Tacconi, Marcus Thelen, Daniel F Legler, Cornelia Halin
Publikováno v:
PLoS ONE, Vol 18, Iss 5, p e0285597 (2023)
Atypical chemokine receptor 3 (ACKR3) is a scavenger of the chemokines CXCL11 and CXCL12 and of several opioid peptides. Additional evidence indicates that ACKR3 binds two other non-chemokine ligands, namely the peptide hormone adrenomedullin (AM) an
Externí odkaz:
https://doaj.org/article/f9990a6da99c47a399804317fc973bdc
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract The exquisite specificity of Toll-like receptors (TLRs) to sense microbial molecular signatures is used as a powerful tool to pinpoint microbial contaminants. Various cellular systems, from native human blood cells to transfected cell lines
Externí odkaz:
https://doaj.org/article/7b436f4ca5ee44b480974adb46c915e2
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Chemokine-guided leukocyte migration is a hallmark of the immune system to cope with invading pathogens. Intruder confronted dendritic cells (DCs) induce the expression of the chemokine receptor CCR7, which enables them to sense and migrate along che
Externí odkaz:
https://doaj.org/article/d91e8a70e3574cf0af38cf3a56de418f
Autor:
Jason Cosgrove, Mario Novkovic, Stefan Albrecht, Natalia B. Pikor, Zhaoukun Zhou, Lucas Onder, Urs Mörbe, Jovana Cupovic, Helen Miller, Kieran Alden, Anne Thuery, Peter O’Toole, Rita Pinter, Simon Jarrett, Emily Taylor, Daniel Venetz, Manfred Heller, Mariagrazia Uguccioni, Daniel F. Legler, Charles J. Lacey, Andrew Coatesworth, Wojciech G. Polak, Tom Cupedo, Bénedicte Manoury, Marcus Thelen, Jens V. Stein, Marlene Wolf, Mark C. Leake, Jon Timmis, Burkhard Ludewig, Mark C. Coles
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Morphogens such as chemokines form gradients to direct graded responses and modulate cell behaviors. Here the authors show, using imaging and computer simulation, that the chemokine CXCL13 originated from follicular reticular cells in the lymph nodes
Externí odkaz:
https://doaj.org/article/a29fe9ea7a8d465093c19a3301a148f3
Autor:
Edith Uetz-von Allmen, Guerric P. B. Samson, Vladimir Purvanov, Takahiro Maeda, Daniel F. Legler
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Dendritic cells (DCs) are potent and versatile professional antigen-presenting cells and central for the induction of adaptive immunity. The ability to migrate and transport peripherally acquired antigens to draining lymph nodes for subsequent cognat
Externí odkaz:
https://doaj.org/article/a08ddc28f69949bb87c24a2c683984fe
Publikováno v:
Cells, Vol 11, Iss 9, p 1444 (2022)
The chemokine receptor CCR7, together with its ligands, is responsible for the migration and positioning of adaptive immune cells, and hence critical for launching adaptive immune responses. CCR7 is also induced on certain cancer cells and contribute
Externí odkaz:
https://doaj.org/article/931ac22226c44bbc8f7c127127d5b0dd