Zobrazeno 1 - 10
of 32
pro vyhledávání: '"F L Graham"'
Autor:
T A Braciak, K Bacon, Z Xing, D J Torry, F L Graham, T J Schall, C D Richards, K Croitoru, J Gauldie
Publikováno v:
The Journal of Immunology. 157:5076-5084
RANTES (regulated on activation, normal T cell expressed and secreted) is a member of the C-C superfamily of chemokines and is reported to function as a potent chemoattractant for monocytes, eosinophils, and a subpopulation of CD4+ T cells. Using a r
Autor:
M J Greenberger, S L Kunkel, R M Strieter, N W Lukacs, J Bramson, J Gauldie, F L Graham, M Hitt, J M Danforth, T J Standiford
Publikováno v:
The Journal of Immunology. 157:3006-3012
IL-12 is a proinflammatory cytokine that has recently been shown to have beneficial effects in the setting of acquired host immunity. To determine the role of IL-12 in innate immunity against Gram-negative bacterial organisms, CBA/J mice were challen
Publikováno v:
The Journal of Immunology. 153:4059-4069
The biologic function of cytokines may be best studied in the context of a defined tissue site. To establish a model for studying the function of IL-6 at local tissue sites, we targeted the IL-6 transgene into the bronchial epithelium in the lung of
Autor:
F L, Graham, L, Prevec
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 7
Adenoviruses have been isolated from a large number of different species (mammalian and fowl) and over 100 different serotypes have been reported, some 43 of them human. The human adenoviruses, particularly types 2, 5, and 12, have been the most exte
Publikováno v:
The Journal of Immunology. 151:5145-5153
The majority of biologic functions assigned to cytokines have been characterized by in vitro assay systems which may not necessarily reflect cytokine roles in vivo. Recently, recombinant virus approaches have allowed tissue-specific expression of for
Autor:
T A, Braciak, W S, Gallichan, F L, Graham, C D, Richards, A J, Ramsay, K L, Rosenthal, J, Gauldie
Publikováno v:
Immunology. 101(3)
In this study, we have examined the in vivo effects of interleukin-5 (IL-5) and IL-6 over-expression on systemic and mucosal immune responses using recombinant human type 5 adenoviruses capable of expressing these cytokines upon infection. A recombin
Autor:
M M, Hitt, F L, Graham
Publikováno v:
Advances in virus research. 55
Autor:
W K, O'Neal, H, Zhou, N, Morral, C, Langston, R J, Parks, F L, Graham, S, Kochanek, A L, Beaudet
Publikováno v:
Molecular medicine (Cambridge, Mass.). 6(3)
BACKGROUND: Certain gene therapy protocols may require multiple administrations of vectors to achieve therapeutic benefit to the patient. This may be especially relevant for vectors such as adenoviral vectors that do not integrate into the host chrom
Publikováno v:
Human gene therapy. 11(5)
The two-plasmid rescue method of constructing Ad vectors, which relies on either homologous or Cre-mediated recombination between two plasmids cotransfected into 293 or 293Cre4 cells, respectively, offers advantages over other approaches because of i
Autor:
M P, Winn, P J, Conlon, K L, Lynn, D N, Howell, D A, Gross, A R, Rogala, A H, Smith, F L, Graham, M, Bembe, L D, Quarles, M A, Pericak-Vance, J M, Vance
Publikováno v:
Kidney international. 55(4)
Familial forms of focal segmental glomerulosclerosis (FFSGS) that exhibit autosomal dominant or recessive patterns of inheritance have been described. The genetic basis of these hereditary forms of FSGS is unknown. One recent study of a kindred from