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An Endoscopic Comparison of Gastroduodenal Injury With Over-the-Counter Doses of Ketoprofen and Acetaminophen

Autor: F L, Lanza, J R, Codispoti, E B, Nelson

Publikováno v: American Journal of Gastroenterology. 93:1051-1054

The objective of this study was to endoscopically assess in healthy subjects the gastrointestinal effects of over-the-counter (OTC) doses of ketoprofen. Ketoprofen is a potent nonsteroidal antiinflammatory agent (NSAID) recently approved for OTC use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39e767ef0513bdb494432afa4ef37f20
https://doi.org/10.1111/j.1572-0241.1998.00327.x

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Clinical Pharmacology of Predisintegrated Ibuprofen 800 mg Tablets: An Endoscopic and Pharmacokinetic Study

Autor: F. L. Lanza, K Perry, H. Friedman, S Francom, Royer Gl, C. E. Seckman

Publikováno v: The Journal of Clinical Pharmacology. 30:57-63

Thirty-five healthy adults were randomized to receive either: (1) ibuprofen 800 mg tablets; (2) ibuprofen 800 mg aqueous suspension; (3) ibuprofen 800 mg orange juice suspension; or (3) 325 mg aspirin tablets. All treatments were tid for 7 days. Phar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f21719fd50e8a716c502552ee60eed
https://doi.org/10.1002/j.1552-4604.1990.tb03439.x

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Placebo-controlled, randomized, evaluator-blinded endoscopy study of risedronate vs. aspirin in healthy postmenopausal women

Autor: F L, Lanza, M F, Rack, Z, Li, S A, Krajewski, M A, Blank

Publikováno v: Alimentary pharmacologytherapeutics. 14(12)

Bisphosphonates are effective treatments for osteoporosis. Since some primary amino bisphosphonates are associated with oesophageal injury, we conducted a study of the upper gastrointestinal effects of risedronate, a pyridinyl bisphosphonate.Healthy,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::da18304f74538b9a6fa17eaaa4ad89f5
https://pubmed.ncbi.nlm.nih.gov/11121916

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Specific inhibition of cyclooxygenase-2 with MK-0966 is associated with less gastroduodenal damage than either aspirin or ibuprofen

Autor: F L, Lanza, M F, Rack, T J, Simon, H, Quan, J A, Bolognese, M E, Hoover, F R, Wilson, S E, Harper

Publikováno v: Alimentary pharmacologytherapeutics. 13(6)

Compared with currently available NSAIDs (which inhibit COX-1 and COX-2 isoforms of cyclooxygenase), MK-0966 (a specific COX-2 inhibitor) is expected to cause less gastrointestinal toxicity.To compare the effect on the upper gastrointestinal mucosae

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::39456069342f4c96d2ae23b41ba97e09
https://pubmed.ncbi.nlm.nih.gov/10383505

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Preliminary study of the safety and efficacy of SC-58635, a novel cyclooxygenase 2 inhibitor: efficacy and safety in two placebo-controlled trials in osteoarthritis and rheumatoid arthritis, and studies of gastrointestinal and platelet effects

Autor: L S, Simon, F L, Lanza, P E, Lipsky, R C, Hubbard, S, Talwalker, B D, Schwartz, P C, Isakson, G S, Geis

Publikováno v: Arthritis and rheumatism. 41(9)

To investigate the efficacy and safety of SC-58635 (celecoxib), an antiinflammatory and analgesic agent that acts by selective cyclooxygenase 2 (COX-2) inhibition and is not expected to cause the typical gastrointestinal (GI), renal, and platelet-rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0473c58b1313485456689eb236a89989
https://pubmed.ncbi.nlm.nih.gov/9751091

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