Zobrazeno 1 - 10
of 56
pro vyhledávání: '"F Kent Hamra"'
Autor:
Frauke Ackermann, Kay Oliver Schink, Christine Bruns, Zsuzsanna Izsvák, F Kent Hamra, Christian Rosenmund, Craig Curtis Garner
Publikováno v:
eLife, Vol 8 (2019)
Loss of function of the active zone protein Piccolo has recently been linked to a disease, Pontocerebellar Hypoplasia type 3, which causes brain atrophy. Here, we address how Piccolo inactivation in rat neurons adversely affects synaptic function and
Externí odkaz:
https://doaj.org/article/69ba1bf9b55043f083573480f4785083
Autor:
Timothy E Richardson, Karen M Chapman, Christina Tenenhaus Dann, Robert E Hammer, F Kent Hamra
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6308 (2009)
Despite remarkable advances in assisted reproductive capabilities approximately 4% of all couples remain involuntarily infertile. In almost half of these cases, a lack of conception can in some measure be attributed to the male partner, wherein de no
Externí odkaz:
https://doaj.org/article/db37524928f34a96b6e44298cb1b160f
Autor:
David Prokai, Ashutosh Pudasaini, Mohammed Kanchwala, Andrew T. Moehlman, Alexandrea E. Waits, Karen M. Chapman, Jaideep Chaudhary, Jesus Acevedo, Patrick Keller, Xing Chao, Bruce R. Carr, F. Kent Hamra
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101880- (2021)
Summary: In adult males, spermatogonia maintain lifelong spermatozoa production for oocyte fertilization. To understand spermatogonial metabolism we compared gene profiles in rat spermatogonia to publicly available mouse, monkey, and human spermatogo
Externí odkaz:
https://doaj.org/article/7a851f768b5b49019ec1a24e649bc647
Autor:
Xinglong Gu, Xia Mao, Marc P. Lussier, Mary Anne Hutchison, Liang Zhou, F. Kent Hamra, Katherine W. Roche, Wei Lu
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
The molecular mechanism controlling the trafficking and function of AMPARs at synapses are not fully understood. Here the authors show that GSG1L, a membrane protein, negatively regulates AMPAR-mediated synaptic transmission and represents a new clas
Externí odkaz:
https://doaj.org/article/da577629600d4e19af92086f063fbc57
Autor:
Susann Michanski, Rohan Kapoor, Anna M. Steyer, Wiebke Möbius, Iris Früholz, Frauke Ackermann, Mehmet Gültas, Craig C. Garner, F. Kent Hamra, Jakob Neef, Nicola Strenzke, Tobias Moser, Carolin Wichmann
Cochlear inner hair cells (IHCs) form specialized ribbon synapses with spiral ganglion neurons that tireless-ly transmit sound information at high rates over long time periods with extreme temporal precision. This functional specialization is essenti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::83e490193e2a19496dcc0b87673caf36
https://doi.org/10.1101/2022.12.15.520589
https://doi.org/10.1101/2022.12.15.520589
Autor:
Karen M. Chapman, Gerardo A. Medrano, Priscilla Jaichander, Jaideep Chaudhary, Alexandra E. Waits, Marcelo A. Nobrega, James M. Hotaling, Carole Ober, F. Kent Hamra
Publikováno v:
Cell Reports, Vol 10, Iss 11, Pp 1828-1835 (2015)
Organisms with targeted genomic modifications are efficiently produced by gene editing in embryos using CRISPR/Cas9 RNA-guided DNA endonuclease. Here, to facilitate germline editing in rats, we used CRISPR/Cas9 to catalyze targeted genomic mutations
Externí odkaz:
https://doaj.org/article/3636e9614fd349e99ff5d4fa5d2528d2
Autor:
Andrew T. Moehlman, David Prokai, Jaideep Chaudhary, Ashutosh Pudasaini, Alexandrea E. Waits, Patrick W. Keller, Mohammed Kanchwala, F. Kent Hamra, Karen M. Chapman, Jesus F. Acevedo, Bruce R. Carr, Xing Chao
Publikováno v:
iScience
iScience, Vol 24, Iss 1, Pp 101880-(2021)
iScience, Vol 24, Iss 1, Pp 101880-(2021)
Summary In adult males, spermatogonia maintain lifelong spermatozoa production for oocyte fertilization. To understand spermatogonial metabolism we compared gene profiles in rat spermatogonia to publicly available mouse, monkey, and human spermatogon
Autor:
Yared H. Kidane, F. Kent Hamra, Alexandra J Rafipay, Jacqueline T. Hecht, Mitchell K. Weston, Jonathan J. Rios, Matthew B. Dobbs, B. Stephens Richards, Nandina Paria, Anas M. Khanshour, Megan J. Wilson, Vanessa De Mello, Aysha B. Khalid, Julia Kozlitina, Neil Vargesson, Christina A. Gurnett, Carol Wise, Reuel Cornelia
Publikováno v:
Hum Mol Genet
Talipes equinovarus (clubfoot, TEV) is a congenital rotational foot deformity occurring in 1 per 1000 births with increased prevalence in males compared with females. The genetic etiology of isolated clubfoot (iTEV) remains unclear. Using a genome-wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9b6ad8a6eb81a1ad80e7c555814e2d9
https://europepmc.org/articles/PMC7823076/
https://europepmc.org/articles/PMC7823076/
Autor:
F. Kent Hamra, Sheila Hoffmann-Conaway, Joanne Falck, Isabelle Straub, Marion Rivalan, Craig C. Garner, Stefan Hallermann, Zsuzsanna Izsvák, Christine Bruns, York Winter, Humaira Munawar, Erik J. Plautz, Frauke Ackermann, Dietmar Schmitz, Marta Orlando
Publikováno v:
The journal of neuroscience 40(14), 2943-2959 (2020). doi:10.1523/JNEUROSCI.2316-19.2020
J Neurosci
J Neurosci
Piccolo, a presynaptic active zone protein, is best known for its role in the regulated assembly and function of vertebrate synapses. Genetic studies suggest a further link to several psychiatric disorders as well as Pontocerebellar Hypoplasia type 3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a27a4c33e7ec7b0613c6b3baef9a9c5c
https://pub.dzne.de/record/151528
https://pub.dzne.de/record/151528
Autor:
Anil K. Agarwal, Jasbir S. Dalal, Shireesha Sankella, Sneha S. Nagamma, Abhimanyu Garg, Richard J. Auchus, Xinli Shao, F. Kent Hamra, Katie Tunison
Publikováno v:
Endocrinology. 158:3954-3973
Defects in the biosynthesis of phospholipids and neutral lipids are associated with cell membrane dysfunction, disrupted energy metabolism, and diseases including lipodystrophy. In these pathways, the 1-acylglycerol-3-phosphate O-acyltransferase (AGP