Zobrazeno 1 - 10 of 61 pro vyhledávání: '"F K, Gorus"'
1
Sustained function of alginate-encapsulated human islet cell implants in the peritoneal cavity of mice leading to a pilot study in a type 1 diabetic patient
Autor: Daniel Pipeleers, Zhidong Ling, L. Schoonjans, Georges Delvaux, F. K. Gorus, Marie Chintinne, Pieter Gillard, Daniel Jacobs-Tulleneers-Thevissen, Bart Keymeulen, Berit L. Strand
Publikováno v: Diabetologia; Vol 56
Alginate-encapsulated human islet cell grafts have not been able to correct diabetes in humans, whereas free grafts have. This study examined in immunodeficient mice whether alginate-encapsulated graft function was inferior to that of free grafts of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12b75c46fd428bd8db1279c59a2713a9
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2
Four-year metabolic outcome of a randomised controlled CD3-antibody trial in recent-onset type 1 diabetic patients depends on their age and baseline residual beta cell mass
Autor: L Kaufman, Chantal Mathieu, Evy Vandemeulebroucke, Daniel Pipeleers, Herman Waldmann, Anette-G. Ziegler, Sophie Candon, U Van de Velde, Lucienne Chatenoud, Robert Hilbrands, Laurent Crenier, C De Block, Bart Keymeulen, M Walter, F. K. Gorus
Publikováno v: Vrije Universiteit Brussel
Diabetologia
AIMS/HYPOTHESIS: The aim of the study was to examine the 48 month outcome of treating recent-onset type 1 diabetic patients for 6 days with humanised CD3-antibody, ChAglyCD3. METHODS: Eighty patients, aged 12-39 years, were recruited for a phase 2 mu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25660f81be5b020ec93b22bf5ee7fc08
https://doi.org/10.1007/s00125-009-1644-9
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4
Proinsulin levels and the proinsulin:c-peptide ratio complement autoantibody measurement for predicting type 1 diabetes
Autor: E. Vandemeulebroucke, P. De Pauw, F. K. Gorus, Ogonnaya C. Ubani, Rui Mao, I. Truyen, C. Van Schravendijk, K. Decochez, I Weets, Daniel Pipeleers, P. N. Jørgensen
Publikováno v: Diabetologia. 48:2322-2329
AIMS/HYPOTHESIS: We investigated whether random proinsulin levels and proinsulin:C-peptide ratio (PI:C) complement immune and genetic markers for identifying relatives at high risk of type 1 diabetes. MATERIALS AND METHODS: During an initial sampling
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::218fad0b3d2d27c3f0bf3adf6544c86c
https://doi.org/10.1007/s00125-005-1959-0
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5
Seasonality in clinical onset of Type 1 diabetes in Belgian patients above the age of 10 is restricted to HLA-DQ2/DQ8-negative males, which explains the male to female excess in incidence
Autor: I Weets, M. Coeckelberghs, Z Laron, Eric Weber, L Kaufman, L Crenier, B. Van der Auwera, Daniel Pipeleers, R. Rooman, C De Block, Kristina Casteels, F. K. Gorus
Publikováno v: Diabetologia
Type 1 diabetes arises from an interplay between environmental and genetic factors. The reported seasonality at diagnosis supports the hypothesis that currently unknown external triggers play a role in the onset of the disease. We investigated whethe
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85dcf2bd96042f9adcf188749383c1d7
https://doi.org/10.1007/s00125-004-1369-8
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6
EPIDEMIOLOGY OF TYPE 1 AND TYPE 2 DIABETES. THE ADDED VALUE OF DIABETES REGISTRIES FOR CONDUCTING CLINICAL STUDIES: THE BELGIAN PARADIGM
Autor: Pedro Couck, D.G. Pipeleers, Ilse Weets, F. K. Gorus
Publikováno v: Acta Clinica Belgica. 59:1-13
Diabetes registries have documented that the lifetime risk of diabetes amounts to at least 10% in the western world. Moreover the prevalence of type 2 diabetes is increasing worldwide especially in developing countries. Furthermore there is a secular
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50907ee369a41d7e8d6957d129215c64
https://doi.org/10.1179/acb.2004.001
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7
Non-transmitted maternal HLA DQ2 or DQ8 alleles and risk of Type I diabetes in offspring: the importance of foetal or post partum exposure to diabetogenic molecules
Autor: M. A. Pani, J. Van Autreve, B. Van der Auwera, Klaus Badenhoop, F. K. Gorus
Publikováno v: Diabetologia. 45:1340-1343
Type I (insulin-dependent) diabetes mellitus results from an immune-mediated destruction of pancreatic beta cells for which HLA haplotypes DR3-DQ2 and DR4-DQ8 represent the strongest genetic risk markers. Mothers of patients with rheumatoid arthritis
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40fb6b669f5fc74fcf7951e5a8b601c5
https://doi.org/10.1007/s00125-002-0900-z
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8
Potential of UCHL1 as biomarker for destruction of pancreatic beta cells
Autor: Geert A. Martens, J. Sadones, V. De Punt, C. Xavier, Katrijn Verhaeghen, Johannes M. F. G. Aerts, Olivier Costa, B. Brackeva, Gert Jan Kramer, F. K. Gorus, Geert Stangé
Publikováno v: Journal of proteomics, 117, 156-167. Elsevier
Europe PubMed Central
There is a clinical need for plasma tests for real-time detection of beta cell destruction, as surrogate endpoint in islet transplantation and immunoprevention trials in type 1 diabetes. This study reports on the use of label-free LC-MS/MS proteomics
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a96eabfb71ce555d17df3693f379d36
https://pubmed.ncbi.nlm.nih.gov/25638021
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9
Genetic structure of IDDM1: two separate regions in the major histocompatibility complex contribute to susceptibility or protection. Belgian Diabetes Registry
Autor: Marius J. Giphart, Hanifi Moghaddam P, F. Schuit, Bart O. Roep, Albert Naipal, Van der Auwera B, F. K. Gorus, de Knijf P
Publikováno v: Diabetes. 47:263-269
We analyzed 11 markers in the IDDM1 region in 120 IDDM patients and 83 healthy control subjects who were fully matched for the highest risk HLA-DQA1*0301-DQB1 *0302/DQA1*0501-DQB1*0201 genotype. Our study provides strong evidence that two regions in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::407b4e540c3687890ea036bab24becab
https://doi.org/10.2337/diabetes.47.2.263
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10
Genetic Structure of IDDM1: Two Separate Regions in the Major Histocompatibility Complex Contribute to Susceptibility or Protection
Autor: B. Van der Auwera, F. K. Gorus, Frans Schuit, Albert Naipal, Marius J. Giphart, Bart O. Roep, P. De Knijf, Payman Hanifi Moghaddam
Publikováno v: Diabetes. 47:263-269
We analyzed 11 markers in the IDDM1 region in 120 IDDM patients and 83 healthy control subjects who were fully matched for the highest risk HLADQA1*O3O1-DQB1*O3O2/DQA1*O5O1-DQB1*O2O1 genotype. Our study provides strong evidence that two regions in th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::84d4bb0fb0bb9c7c622ac31ddd4b457b
https://doi.org/10.2337/diab.47.2.263
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