Establishment of Parameters for Optimal Transduction Efficiency and Antitumor Effects with Purified High-Titer HSV-TK Retroviral Vector in Established Solid Tumors

Autor: B Laubert, F J Burrows, C Ibañez, W R Smiley, B D Howard, Timothy Fong, W S Summers

Publikováno v: Human Gene Therapy. 8:965-977

Suicide gene therapy using the herpes simplex thymidine kinase gene and ganciclovir is an attractive strategy for solid tumors. Early animal studies involved intratumoral injection of retroviral producer cells or unprocessed supernatant to generate a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f1f90ce3682271008d114bd5a9a0b9f
https://doi.org/10.1089/hum.1997.8.8-965

Visible Light-Mediated Late-Stage Thioetherification of Mercaptopurine Derivatives.

Autor: Ge Y; School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, P. R.China., Peng Y; School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, P. R.China., Xie R; School of Chemistry and Chemical Engineering, Southeast University, Nanjing, 211189, P. R.China., Luo Y; Shanghai Key Laboratory for Molecular Engineer of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China., Li Y; Shanghai Key Laboratory for Molecular Engineer of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China., Chen G; Shanghai Key Laboratory for Molecular Engineer of Chiral Drugs, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai, 200240, P. R. China.; Key Laboratory of Green and High-value Utilization of Salt Lake Resources, Qinghai Institute of Salt Lakes, Chinese Academy of Sciences, Xining, Qinghai, 810008, P. R. China.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Aug 27; Vol. 30 (48), pp. e202401774. Date of Electronic Publication: 2024 Aug 07.

Purified herpes simplex thymidine kinase Retrovector particles. I. In vitro characterization, in situ transduction efficiency, and histopathological analyses of gene therapy-treated brain tumors

Autor: C A, Kruse, M D, Roper, B K, Kleinschmidt-DeMasters, S J, Banuelos, W R, Smiley, J M, Robbins, F J, Burrows

Publikováno v: Cancer gene therapy. 4(2)

Replication-defective, highly purified retroviral vectors (Retrovector), at titers of 10(8) colony forming units/mL, were prepared that conferred either beta-galactosidase or herpes simplex thymidine kinase (HSV-TK) activity. 9L gliosarcoma cells, tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::87bdc15df997a5cb0f96637c71569fe7
https://pubmed.ncbi.nlm.nih.gov/9080121

A murine model for antibody-directed targeting of vascular endothelial cells in solid tumors

Autor: F J, Burrows, Y, Watanabe, P E, Thorpe

Publikováno v: Cancer research. 52(21)

An attractive approach to the therapy of solid tumors would be to target cytotoxic agents or coagulants to the vasculature of the tumor rather than to the tumor cells themselves. This strategy has 3 advantages: (a) it should be applicable to many typ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c41b3ceea35444e52df6592502944a80
https://pubmed.ncbi.nlm.nih.gov/1394221

Mechanochemical Nickel‐Catalyzed Carbon‐Sulfur Bond Formation between Aryl Iodides and Aromatic Sulfur Surrogates.

Autor: Hao, Xiujia¹ (AUTHOR), Feng, Daming¹ (AUTHOR), Chen, Hongguang¹ (AUTHOR), Huang, Peng^1,2 (AUTHOR) huangp019@126.com, Guo, Fang¹ (AUTHOR) fguo@lnu.edu.cn

Publikováno v: Chemistry - A European Journal. 10/26/2023, Vol. 29 Issue 60, p1-8. 8p.