Zobrazeno 1 - 10
of 395
pro vyhledávání: '"F Ivy, Carroll"'
Autor:
Amal El Daibani, Joseph M. Paggi, Kuglae Kim, Yianni D. Laloudakis, Petr Popov, Sarah M. Bernhard, Brian E. Krumm, Reid H. J. Olsen, Jeffrey Diberto, F. Ivy Carroll, Vsevolod Katritch, Bernhard Wünsch, Ron O. Dror, Tao Che
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Biased signaling in κ-opiod receptors (KOR) offer an attractive strategy for pain management. Here the authors identify determinants of KOR signaling bias using structural methods in combination with molecular dynamics simulations.
Externí odkaz:
https://doaj.org/article/937c35a4ce1e4c9d8b16be30f0910f0c
Autor:
Kenneth M. McCullough, Seyma Katrinli, Jakob Hartmann, Adriana Lori, Claudia Klengel, Galen Missig, Torsten Klengel, Nicole A. Langford, Emily L. Newman, Kasey J. Anderson, Alicia K. Smith, F. Ivy Carroll, Kerry J. Ressler, William A. Carlezon
Publikováno v:
Translational Psychiatry, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Exposure to stress triggers biological changes throughout the body. Accumulating evidence indicates that alterations in immune system function are associated with the development of stress-associated illnesses such as major depressive disord
Externí odkaz:
https://doaj.org/article/98da7415c3554e35a9732e7817ea59c7
Autor:
Tao Che, Justin English, Brian E. Krumm, Kuglae Kim, Els Pardon, Reid H. J. Olsen, Sheng Wang, Shicheng Zhang, Jeffrey F. Diberto, Noah Sciaky, F. Ivy Carroll, Jan Steyaert, Daniel Wacker, Bryan L. Roth
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Recent studies revealed that G protein-coupled receptors rapidly interconvert between multiple states. Here, authors use the kappa opioid receptor (KOR) and show how two state-dependent nanobodies provide real-time reporting of ligand stabilized stat
Externí odkaz:
https://doaj.org/article/ea2f79e5cad94be58517658c2739cb15
Autor:
Tyson R. Baird, Kimberly N. Karin, Samuel A. Marsh, F. Ivy Carroll, J. M. L. Medina-Contreras, S. Stevens Negus, Jose M. Eltit
Publikováno v:
Psychopharmacology. 240:969-981
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7794f6509f5162140ac7fdaf653fc7b5
https://doi.org/10.1007/s00213-023-06340-8
https://doi.org/10.1007/s00213-023-06340-8
Autor:
Lois S Akinola, Deniz Bagdas, Yasmin Alkhlaif, Asti Jackson, Cenk O Gurdap, Elnaz Rahimpour, F. Ivy Carroll, Roger L Papke, M. Imad Damaj
Publikováno v:
Journal of Psychopharmacology. 36:1280-1293
Background: Because of their implications in several pathological conditions, α4β2* nicotinic acetylcholine receptors (nAChRs) are potential targets for the treatment of nicotine dependence, pain, and many psychiatric and neurodegenerative diseases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5dae18fcde5ca41d3f5e7abd83ba85
https://doi.org/10.1177/02698811221132214
https://doi.org/10.1177/02698811221132214
Autor:
Renata V. Bueno, Samuel Davis, Alice Dawson, Pauline W. Ondachi, F. Ivy Carroll, William N. Hunter
Publikováno v:
Acta Crystallographica Section D Structural Biology. 78:353-362
Low-nanomolar binding constants were recorded for a series of six 2′-fluoro-(carbamoylpyridinyl)deschloroepibatidine analogues with acetylcholine-binding protein (AChBP). The crystal structures of three complexes with AChBP reveal details of molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf6ea6624b47abdef07b2b471d46f424
https://doi.org/10.1107/s2059798322000754
https://doi.org/10.1107/s2059798322000754
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Background: Preclinical and clinical data suggest that a compound which binds potently to and inhibits the dopamine transporter, but with a slower onset and offset rate than cocaine and with less abuse potential and psychomotor stimulant activity, co
Externí odkaz:
https://doaj.org/article/081d374e51af4ad8a6f5f2742ceac3f4
Autor:
Abigail Laman-Maharg, Alexia V. Williams, Mikaela D. Zufelt, Vanessa A. Minie, Stephanie Ramos-Maciel, Rebecca Hao, Evelyn Ordoñes Sanchez, Tiffany Copeland, Jill L. Silverman, Angelina Leigh, Rodney Snyder, F. Ivy Carroll, Timothy R. Fennell, Brian C. Trainor
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
There is growing evidence that kappa opioid receptor (KOR) antagonists could be a useful class of therapeutics for treating depression and anxiety. However, the overwhelming majority of preclinical investigations examining the behavioral effects of K
Externí odkaz:
https://doaj.org/article/cd508b77e458462eb06fb2c02901908e
Publikováno v:
Annals of the New York Academy of Sciences. 1489:48-77
During 2012-2018, the clandestine manufacture of new psychoactive substances (NPS) designed to circumvent substance control regulations increased exponentially worldwide, with concomitant increase in fatalities. This review focuses on three compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37380b12d1f1da8fbce1c3d9085a4fab
https://doi.org/10.1111/nyas.14349
https://doi.org/10.1111/nyas.14349
Autor:
Els Pardon, Justin G. English, F. Ivy Carroll, Brian E. Krumm, Jeffrey F. DiBerto, Bryan L. Roth, Noah Sciaky, Sheng Wang, Reid H.J. Olsen, Tao Che, Daniel Wacker, Shicheng Zhang, Kuglae Kim, Jan Steyaert
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications
Recent studies show that GPCRs rapidly interconvert between multiple states although our ability to interrogate, monitor and visualize them is limited by a relative lack of suitable tools. We previously reported two nanobodies (Nb39 and Nb6) that sta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664ff244c7e7405559e63bc768c4edf8
http://link.springer.com/article/10.1038/s41467-020-14889-7
http://link.springer.com/article/10.1038/s41467-020-14889-7