c-FLIP regulates autophagy by interacting with Beclin-1 and influencing its stability

Autor: Angelo Facchiano, Luana Tomaipitinca, Claudia Giampietri, Salvatore Rizza, Antonio Filippini, Elio Ziparo, Simonetta Petrungaro, F. Giulitti, Amit Dubey, Pasquale D’Acunzo, Francesco Cecconi, Eugenio Gaudio

Publikováno v: Cell Death and Disease, Vol 12, Iss 7, Pp 1-10 (2021)
Cell death and disease 12 (2021). doi:10.1038/s41419-021-03957-5
info:cnr-pdr/source/autori:Luana Tomaipitinca, Simonetta Petrungaro, Pasquale D'Acunzo, Angelo Facchiano, Amit Dubey, Salvatore Rizza, Federico Giulitti, Eugenio Gaudio, Antonio Filippini, Elio Ziparo, Francesco Cecconi & Claudia Giampietri/titolo:c-FLIP regulates autophagy by interacting with Beclin-1 and influencing its stability/doi:10.1038%2Fs41419-021-03957-5/rivista:Cell death and disease/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:12
Cell Death & Disease

c-FLIP (cellular FLICE-like inhibitory protein) protein is mostly known as an apoptosis modulator. However, increasing data underline that c-FLIP plays multiple roles in cellular homoeostasis, influencing differently the same pathways depending on it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf615530a9b07a402fd8e76afb6a9d6f
https://doi.org/10.1038/s41419-021-03957-5

The FXR agonist obeticholic acid inhibits the cancerogenic potential of human cholangiocarcinoma

Autor: L. Nevi, Gian Luca Grazi, D. Costantini, Vincenzo Cardinale, S. Safarikia, Alessandra Giorgi, Chiara Napoletano, E. Manzi, Luciano Adorini, A. M. De Rose, Domenico Alvaro, Felice Giuliante, S. Di Matteo, Diletta Overi, Fabio Melandro, Guido Carpino, Eugenio Gaudio, M.C. Bragazzi, P.B. Berloco, F. Giulitti

Publikováno v: PLoS ONE, Vol 14, Iss 1, p e0210077 (2019)
PLoS ONE

Cholangiocarcinoma (CCA) is an aggressive cancer with high resistance to chemotherapeutics. CCA is enriched in cancer stem cells, which correlate with aggressiveness and prognosis. FXR, a member of the metabolic nuclear receptor family, is markedly d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0660502a6d45ad79d748d93079d000
http://hdl.handle.net/11573/1233660

The cancerogenic potential of primary human Cholangioracinoma cells is inhibited by Obeticholic Acid, a Farnesoid X Receptor (FXR) agonist

Autor: Vincenzo Cardinale, M.C. Bragazzi, D. Costantini, Gian Luca Grazi, Domenico Alvaro, P.B. Berloco, S. Safarikia, Eugenio Gaudio, L. Nevi, Guido Carpino, S. Di Matteo, A.M. Derose, Chiara Napoletano, E. Manzi, Felice Giuliante, F. Giulitti, Fabio Melandro, M. Colantonio

Publikováno v: Digestive and Liver Disease. 50:22-23

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0a8a9f7ffc3ba2e411f881ab52ed7ae8
https://doi.org/10.1016/j.dld.2018.01.082

Metformin reduces cell migration and down-regulates epithelial to mesenchymal transition by AMPK / Foxo3a pathway in human intrahepatic cholangiocarcinoma

Autor: Vincenzo Cardinale, Anna Maria Lustri, Guido Carpino, Chiara Napoletano, Gian Luca Grazi, S. Di Matteo, E. Manzi, L. Nevi, Jessica Faccioli, P.B. Berloco, Felice Giuliante, Daniele Costantini, M.C. Bragazzi, A.M. Derose, F. Giulitti, Domenico Alvaro

Publikováno v: Journal of Hepatology. 66:S636

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e1a2e70b744d41414c65df2b46d4fc10
https://doi.org/10.1016/s0168-8278(17)31723-3

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