Zobrazeno 1 - 10
of 27
pro vyhledávání: '"F G, Njoroge"'
Autor:
Xiao Tong, Sony Agrawal, Latha G. Nair, Melissa Blackman, Francisco Velazquez, Girijavallabhan, John Pichardo, Andrea Hart, Robert Chase, Srikanth Venkatraman, Kevin X. Chen, N.-Y. Shih, F. G. Njoroge, Stephane L. Bogen, Andrew Prongay, K.-C. Cheng, Piwinski John J, Wen-Lian Wu
Publikováno v:
Journal of Medicinal Chemistry. 52:336-346
Hepatitis C virus (HCV) infection is the major cause of chronic liver disease, leading to cirrhosis and hepatocellular carcinoma, and affects more than 200 million people worldwide. Although combination therapy of interferon-alpha and ribavirin is re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cbda4400fc040b1f47b5285563c6301
https://doi.org/10.1021/jm800940u
https://doi.org/10.1021/jm800940u
Autor:
Levy Odile Esther, B. Marten, Ashit K. Ganguly, Andrew Prongay, Patrick Pinto, Bruce A. Malcolm, Tin-Yau Chan, Parekh Tejal N, Santhanam Bama, Lim-Wilby Marguerita, Z. Zhu, Vincent Madison, Liwu Hong, Ashok Arasappan, Edwin Jao, Stephane L. Bogen, Hongwu Wang, Kemp Scott Jeffrey, F. G. Njoroge, Srikanth Venkatraman, Nanhua Yao, Kevin X. Chen, Nancy Butkiewicz, Mckittrick Brian A, John Pichardo, Henry M. Vaccaro, Liu Yi-Tsung, V. Girijavallabhan, Anil K. Saksena, Raymond G. Lovey, Richard N. Ingram, Haining Gu, Russell E. Pike, Frank Bennett, Xiaozheng Yang, Susan Y. Tamura
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 15:4180-4184
We have discovered that introduction of appropriate amino acid derivatives at P 2 ′ position improved the binding potency of P3-capped α-ketoamide inhibitors of HCV NS3 serine protease. X-ray crystal structure of one of the inhibitors (43) bound t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78f56ad19fec0b970200e58a9a29521e
https://doi.org/10.1016/j.bmcl.2005.06.091
https://doi.org/10.1016/j.bmcl.2005.06.091
Autor:
Chin-Chung Lin, Amin A. Nomeir, Ashit K. Ganguly, Patrick Pinto, Matthew Bryant, Ming Liu, F. G. Njoroge, Bancha Vibulbhan, Walter R. Bishop, Doll Ronald J, V. Girijavallabhan
Publikováno v:
Journal of Medicinal Chemistry. 41:1561-1567
We previously reported compound 1 as a potent farnesyl protein transferase (FPT) inhibitor that exhibited reasonable pharmacokinetic stability and showed moderate in vivo activity against a variety of tumor cell lines. The analogous C-11 single compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab0bce4af7df9c919504947197a4bc2e
https://doi.org/10.1021/jm980013b
https://doi.org/10.1021/jm980013b
Autor:
Alan K. Mallams, Doll Ronald J, Shiyong Wang, Jesse Wong, Walter R. Bishop, Ashit K. Ganguly, F. G. Njoroge, Donna Carr, Linda James, Bancha Vibulbhan, Taveras Arthur G, Z. Li, C. Nardo, I. King, James J. Kaminski, Joanne M. Petrin, Paul Kirschmeier, V. Girijavallabhan, Stacy W. Remiszewski, Ming Liu, Carmen S. Alvarez, Randall R. Rossman, Chin-Chung Lin, Mathew S. Bryant, Mark E. Snow, Joseph J. Catino
Publikováno v:
Bioorganic & Medicinal Chemistry. 5:93-99
Ras farnesylation by farnesyl protein transferase (FPT) is an intracellular event that facilitates the membrane association of the ras protein and is involved in the signal transduction process. FPT inhibition could be a novel, noncytotoxic method of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fdd49eb71b5afed18bb647abc8d9d3f
https://doi.org/10.1016/s0968-0896(96)00205-2
https://doi.org/10.1016/s0968-0896(96)00205-2
Autor:
Edgar F. Meyer, F.X. Gomis-Ruth, Istvan Botos, Wolfram Bode, Dachuan Zhang, F. G. Njoroge, C. Blood, R. Doll, J. W. Fox
Publikováno v:
Proceedings of the National Academy of Sciences. 91:8447-8451
The structure of the metalloproteinase and hemorrhagic toxin atrolysin C form d (EC 3.4.24.42), from the venom of the western diamondback rattlesnake Crotalus atrox, has been determined to atomic resolution by x-ray crystallographic methods. This stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3009b79dea84f2cf7176dd185b7bc145
https://doi.org/10.1073/pnas.91.18.8447
https://doi.org/10.1073/pnas.91.18.8447
Autor:
Joanne M. Petrin, F. G. Njoroge, Bancha Vibulbhan, Walter R. Bishop, Doll Ronald J, V. Girijavallabhan, Ashit K. Ganguly, Carmen S. Alvarez
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af2e195718639e40e8526cb994a5355f
https://doi.org/10.1002/chin.199723171
https://doi.org/10.1002/chin.199723171
Autor:
Tze-Ming Chan, F. G. Njoroge, Ashit K. Ganguly, Rebecca Osterman, Patrick Pinto, Bancha Vibulbhan, V. Girijavallabhan, J. del Rosario, Doll Ronald J, Stacy W. Remiszewski
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db6b3183b578aa926abe83c448a31f02
https://doi.org/10.1002/chin.199827183
https://doi.org/10.1002/chin.199827183
Autor:
Xiao Tong, Andrew Prongay, Kevin X. Chen, Frank Bennett, Ashok Arasappan, Weidong Pan, Francisco Velazquez, Hendrata Siska, Mousumi Sannigrahi, Srikanth Venkatraman, Zhuyan Guo, Anil K. Saksena, Yuhua Huang, F. G. Njoroge, Latha G. Nair, V. Girijavallabhan, Stephane L. Bogen, John Pichardo, K.-C. Cheng, Raymond G. Lovey
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(8)
In the search for a second generation HCV protease inhibitor, molecular modeling studies of the X-ray crystal structure of Boceprevir® 1 bound to the NS3 protein suggest that expansion into the S4 pocket could provide additional hydrophobic Van der
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a1124dfebf77a40dd9a715d7fc311f7
https://pubmed.ncbi.nlm.nih.gov/20303756
https://pubmed.ncbi.nlm.nih.gov/20303756
Autor:
A, Arasappan, F G, Njoroge, T-Y, Chan, F, Bennett, S L, Bogen, K, Chen, H, Gu, L, Hong, E, Jao, Y-T, Liu, R G, Lovey, T, Parekh, R E, Pike, P, Pinto, B, Santhanam, S, Venkatraman, H, Vaccaro, H, Wang, X, Yang, Z, Zhu, B, Mckittrick, A K, Saksena, V, Girijavallabhan, J, Pichardo, N, Butkiewicz, R, Ingram, B, Malcolm, A, Prongay, N, Yao, B, Marten, V, Madison, S, Kemp, O, Levy, M, Lim-Wilby, S, Tamura, A K, Ganguly
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(19)
We have discovered that introduction of appropriate amino acid derivatives at P'2 position improved the binding potency of P3-capped alpha-ketoamide inhibitors of HCV NS3 serine protease. X-ray crystal structure of one of the inhibitors (43) bound to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::58a75cc30fd2fcc888c1c51c0f4669e1
https://pubmed.ncbi.nlm.nih.gov/16087332
https://pubmed.ncbi.nlm.nih.gov/16087332
Autor:
Stacy Remiszewski, W. R. Bishop, Ronald J. Maplewood Doll, Randall R. Rossman, J. Desai, C. J. Aki, Corey Strickland, J. Deskus, P. Kirschmeier, Robert Patton, Mathew S. Bryant, Ronald Wolin, D. F. Rane, Carmen S. Alvarez, James Wang, J. del Rosario, Y. Liu, F. G. Njoroge, John D. Kelly, Donna Carr, Amin A. Nomeir, P. Pinto, B. Vibulbhan, Cooper Alan B, Adriano Afonso, Ming Liu, Linda James, Michael Connolly, V. Girijavallabhan, Patricia C. Weber, Chao Jianping, A. K. Ganguly, Alan K. Mallams, Lynn Wang, Arthur G. Taveras
Publikováno v:
Anticancer Agents ISBN: 9780841237452
Anticancer Agents: Frontiers in Cancer Chemotherapy
Anticancer Agents: Frontiers in Cancer Chemotherapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4b7cd535d2226118db7c5197f319cee
https://doi.org/10.1021/bk-2001-0796.ch013
https://doi.org/10.1021/bk-2001-0796.ch013
