Výsledky vyhledávání - "F G, Mastronardi"

Isolation and identification of proteolipid proteins injimpy mouse brain

Autor: F. G. Mastronardi, Mario A. Moscarello, A. M. Fannon

Publikováno v: Neurochemical Research. 19:1005-1012

Proteolipids were isolated from 20 day old normal and jimpy mouse brain by extraction into chloroform-methanol (2:1, w/v), delipidated by size-exclusion HPLC, and analyzed by SDS-PAGE, Western blots, amino acid analyses, and N-terminal sequencing. SD

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c85d630c35e57fe0f52b6a5ad53c49b
https://doi.org/10.1007/bf00968710

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Multiple sclerosis: an important role for post-translational modifications of myelin basic protein in pathogenesis

Autor: J K, Kim, F G, Mastronardi, D D, Wood, D M, Lubman, R, Zand, M A, Moscarello

Publikováno v: Molecularcellular proteomics : MCP. 2(7)

Myelin basic protein (MBP) represents a candidate autoantigen in multiple sclerosis (MS). We isolated MBP from normal and MS human white matter and purified six components (charge isomers) to compare the post-translational modifications on each. The

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::50a9b4457c0f9e7917a3fdbf4a489508
https://pubmed.ncbi.nlm.nih.gov/12832457

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Peptidylarginine deiminase: a candidate factor in demyelinating disease

Autor: M A, Moscarello, L, Pritzker, F G, Mastronardi, D D, Wood

Publikováno v: Journal of neurochemistry. 81(2)

In earlier studies we demonstrated that an increase in the relative amounts of citrullinated myelin basic protein (MBP) was found in multiple sclerosis (Moscarello et al. 1994). To determine the temporal relationship between the citrullinated MBP and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::83607f8ed8904d55a409fd173450498a
https://pubmed.ncbi.nlm.nih.gov/12064481

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Myelin basic protein in experimental allergic encephalomyelitis is not affected at the posttranslational level: implications for demyelinating disease

Autor: F G, Mastronardi, A, al-Sabbagh, P A, Nelson, J, Rego, B I, Roots, M A, Moscarello

Publikováno v: Journal of neuroscience research. 44(4)

The microheterogeneity of myelin basic protein, expressed as the ratio between the least cationic (C-8) charge isomer and the most cationic (C-1), was examined in experimental allergic encephalomyelitis (EAE) cases. These included acute EAE of 2 mont

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7fd24a46ec6eadc8cf6c9bdfb24a845d
https://pubmed.ncbi.nlm.nih.gov/8739153

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Loss of myelin basic protein cationicity in DM20 transgenic mice is dosage dependent

Autor: F G, Mastronardi, C A, Ackerley, B I, Roots, M A, Moscarello

Publikováno v: Journal of neuroscience research. 44(4)

Demyelination in the transgenic mice depended on the dosage of the cDNA for DM20, in which low copy numbers (two to four and 17 copies of the minigene) showed no signs of demyelination. However when transgenic mice with 17 copies were made homozygous

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::58de7e3d17ecf1060d2a366042850b57
https://pubmed.ncbi.nlm.nih.gov/8739149

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