Zobrazeno 1 - 10
of 25
pro vyhledávání: '"F G, Kern"'
Publikováno v:
Journal of Biological Chemistry. 266:2606-2614
A new member, hARF4, of the ADP-ribosylation factor (ARF) family, a subset of the superfamily of regulatory GTP-binding proteins, has been cloned from a cDNA expression library. Two other human ARF cDNA sequences, designated human ARF1 and ARF3, have
Publikováno v:
Cancer research. 59(19)
Mice bearing primary tumors produced by LacZ-tagged MCF-7 human breast carcinoma cells transfected with fibroblast growth factor (FGF) 1 have frequent micrometastases, but macrometastases are not observed. i.v. injection of FGF-1-transfected tumor ce
Autor:
S W, McLeskey, L, Zhang, D, El-Ashry, B J, Trock, C A, Lopez, S, Kharbanda, C A, Tobias, L A, Lorant, R S, Hannum, R B, Dickson, F G, Kern
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 4(3)
Although the antiestrogen tamoxifen has been the mainstay of therapy for estrogen receptor (ER)-positive breast cancer, successful treatment of responsive tumors is often followed by the acquisition of tamoxifen resistance. Subsequently, only 30-40%
Publikováno v:
Cancer research. 58(2)
To determine the extent to which autocrine effects of acidic fibroblast growth factor (FGF)-1 overexpression contribute to an increased malignant phenotype, FGF-1-transfected MCF-7 cells were retransfected with a FGF receptor (FGFR1) vector encoding
Publikováno v:
Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 5(12)
Overexpression of epidermal growth factor receptor (EGFR) is correlated with loss of estrogen receptor and poor prognosis in breast cancer. To investigate this phenomenon, we transfected a cytomegalovirus expression vector directing the expression of
Publikováno v:
Cancer research. 54(19)
Fibroblast growth factors (FGFs) bind to cell membrane receptors and activate signal transduction pathways related to cell growth, angiogenesis, and tumorigenesis. FGFs have been shown to be abundantly expressed in some of the human tumors, which are
Publikováno v:
Cancer research. 54(2)
Overexpression of some transmembrane tyrosine kinase growth factor receptors in breast and other tumors has been found to correlate with poor prognosis. Following the cloning of the first two members of the fibroblast growth factor family of receptor
Publikováno v:
Cancer research. 53(9)
We recently established transfectants of MCF-7 human breast cancer cells with fibroblast growth factor 4 (fgf-4) that showed rapid growth and spontaneous metastasis in ovariectomized and tamoxifen-treated nude mice. To establish a spontaneous metasta
Publikováno v:
Cancer research. 53(8)
In a preceding paper (D. B. Alexander et al., Cancer Res., 53: 1808-1815, 1993), we demonstrated that the in vitro glucocorticoid inhibition of Con8 mammary tumor cell growth is accompanied by the disruption of a transforming growth factor alpha (TGF
Publikováno v:
The Journal of biological chemistry. 266(4)
A new member, hARF4, of the ADP-ribosylation factor (ARF) family, a subset of the superfamily of regulatory GTP-binding proteins, has been cloned from a cDNA expression library. Two other human ARF cDNA sequences, designated human ARF1 and ARF3, have