The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

Autor: John Connolly, John C. Whittaker, Helen Ireland, Hynek Pikhart, Olaf H. Klungel, Claudia Langenberg, Juan P. Casas, Y. van der Graaf, Anne Peasey, Emelia J. Benjamin, Meena Kumari, Nicholas J. Timpson, Růžena Kubínová, P.J. Talmud, Nita G. Forouhi, Verschuren Wmm., KaWah Li, Engmann Jel., C Chung, Tina Shah, Damiano Baldassarre, Mika Kivimäki, Eric J. Brunner, John Hardy, Karoline Kuchenbaecker, Charles B. Eaton, Y. T. van der Schouw, Michael V. Holmes, S. J. Bielinski, Jaroslav A. Hubacek, P. A. Doevendans, Susan Redline, Berta Almoguera Castillo, Westendorp Rgj., Reecha Sofat, Yiran Guo, Leslie A. Lange, Debbie A Lawlor, James G. Wilson, John Gallacher, Richard S. Houlston, Martin Bobak, Maarten Leusink, Andrzej Pajak, George Davey Smith, James F. Meschia, Peter H. Whincup, Rebecca Hardy, Michael Marmot, Jeffrey W. Stephens, Brendan J. Keating, Diana Kuh, Delaney Jac., Mikhail I. Voevoda, N. C. Onland-Moret, Timothy M. Frayling, Hakon Hakonarson, S Bandenelli, Frank Dudbridge, G Jan de Borst, F G Fowkes, Migle Baceviciene, Gordon D.O. Lowe, Gerjan Navis, Alexander P. Reiner, Simon P. Mooijaart, Phil Howard, Boer Jma., Stephen E. Epstein, A. de Boer, Ian Ford, U de Faire, Abdonas Tamosiunas, Malcolm G. Dunlop, AB Singleton, Nicholas J. Wareham, Renate B. Schnabel, Johan Wouter Jukema, Naveed Sattar, Folkert W. Asselbergs, Fotios Drenos, Jutta Palmen, Christina L. Wassel, Sofia Malyutina, Daniel I. Swerdlow, Tetsu Tanaka, Ron T. Gansevoort, Julian Peto, Jenna Price, Bakker Sjl., Ian Tomlinson, Yun Li, Bengt Sennblad, Jackie A. Cooper, Jian'an Luan, Aroon D. Hingorani, JoAnn E. Manson, Roman Pfister, Mailand-van der Zee A-H., I. Mateo Leach, Anders Hamsten, Mike A. Nalls, Yoav Ben-Shlomo, Richard W Morris, Joe Devaney, Marlene C. W. Stewart, P A de Jong, Steve E. Humphries, Roman Topor-Madry, P. van der Harst, Jennifer G. Robinson, Andrew Wong, Luigi Ferrucci, Elena Tremoli, Ioanna Tzoulaki, Mary-Susan Burnett

Publikováno v: The Lancet
The Lancet, 379(9822), 1214-1224. ELSEVIER SCIENCE INC
Hingorani, A D, Casas, J P, Price, J, Stewart, M & Dunlop, M & Tomlinson, I 2012, ' The interleukin-6 receptor as a target for prevention of coronary heart disease : a mendelian randomisation analysis ', The Lancet, vol. 379, no. 9822, pp. 1214-24 . https://doi.org/10.1016/S0140-6736(12)60110-X
The Lancet, 379(9822), 1214-1224. Elsevier Limited
Swerdlow, D I, Holmes, M V, Kuchenbaecker, K B, Engmann, J E L, Shah, T, Sofat, R, Guo, Y, Chung, C, Peasey, A & Timpson, N J & Casas, J P 2013, ' The interleukin-6 receptor as a target for prevention of coronary heart disease : a mendelian randomisation analysis ', Lancet, vol. 379, no. 9822, pp. 1214-1224 . https://doi.org/10.1016/S0140-6736(12)60110-X
The Lancet; Vol 379

SummaryBackgroundA high circulating concentration of interleukin 6 is associated with increased risk of coronary heart disease. Blockade of the interleukin-6 receptor (IL6R) with a monoclonal antibody (tocilizumab) licensed for treatment of rheumatoi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60303f253dccdcfa3075f1ed04fc1362

Fiber intake, constipation, and risk of varicose veins in the general population: Edinburgh Vein Study

Autor: A J, Lee, C J, Evans, C M, Hau, F G, Fowkes

Publikováno v: Journal of clinical epidemiology. 54(4)

The purpose of the present study was to determine the relationship between fiber intake, constipation, and clinical venous disease in the general population. The Edinburgh Vein Study was comprised of 1566 men and women aged 18-64 years who were selec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f8c928b932908a47ca1785752ea31155
https://pubmed.ncbi.nlm.nih.gov/11297893

Surgery for small asymptomatic abdominal aortic aneurysms

Autor: D J, Ballard, F G, Fowkes, J T, Powell

Publikováno v: The Cochrane database of systematic reviews. (2)

An aneurysm is an abnormal ballooning of an artery. One site in which this occurs is in the abdominal aorta, which is the major artery running through the abdomen. Some abdominal aortic aneurysms (AAA) present as an emergency and require surgery; oth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b06b069f44630e7ff3acd68c21d92d23
https://pubmed.ncbi.nlm.nih.gov/18843626

Plasma fibrinogen, haemostatic factors and prediction of peripheral arterial disease in the Edinburgh Artery Study

Autor: F B, Smith, A J, Lee, C M, Hau, A, Rumley, G D, Lowe, F G, Fowkes

Publikováno v: Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 11(1)

The role of fibrinogen and other haemostatic factors in prediction of peripheral arterial disease (PAD) has not been established. We examined the associations of plasma fibrinogen, von Willebrand Factor (vWF), tissue plasminogen activator (t-PA) anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::39139dd445a53dc242c1d4ee97984635
https://pubmed.ncbi.nlm.nih.gov/10691098

Fibrinogen, factor VII and PAI-1 genotypes and the risk of coronary and peripheral atherosclerosis: Edinburgh Artery Study

Autor: A J, Lee, F G, Fowkes, G D, Lowe, J M, Connor, A, Rumley

Publikováno v: Thrombosis and haemostasis. 81(4)

There are now many epidemiological studies that have shown a relationship between haemostatic factors and subsequent risk of both coronary and peripheral arterial disease. However, there is less information on the association between genetic variatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bff045db882abc40b311050d6402df59
https://pubmed.ncbi.nlm.nih.gov/10235438