Zobrazeno 1 - 10
of 37
pro vyhledávání: '"F G, Berger"'
Publikováno v:
Endocrinology. 134:1179-1187
In proximal tubule cells of the mouse kidney, transcription of a number of genes is induced by androgens. Although a great deal of molecular and genetic information on the induction process has accumulated, the lack of an appropriate cell culture sys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::572d0bd0345c5d547785058fc24e481f
https://doi.org/10.1210/endo.134.3.8119157
https://doi.org/10.1210/endo.134.3.8119157
Publikováno v:
Journal of Biological Chemistry. 269:2215-2224
Although expression of the haptoglobin (HP) as an acute phase reactant is evolutionarily conserved among mammals, there are differences among species with regard to the hormones required for stimulation. Using primary hepatocyte cultures, we show tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ae0fbefaa2b17ec266b76bafad18967c
https://doi.org/10.1016/s0021-9258(17)42156-9
https://doi.org/10.1016/s0021-9258(17)42156-9
Publikováno v:
The Journal of Immunology. 144:4392-4398
alpha-1-Acid glycoprotein (AGP), which is produced in the mammalian liver and secreted into the blood-stream, is regulated by steroid hormones and by mediators of the acute phase response. In vitro transfection studies have shown that the response to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4029eb65ffaa3a53533657f062caa31a
https://doi.org/10.4049/jimmunol.144.11.4392
https://doi.org/10.4049/jimmunol.144.11.4392
Publikováno v:
Molecular and Cellular Biology. 10:760-769
alpha 1-Antitrypsin (AT), the major elastase inhibitor in mammalian serum, is produced primarily in the liver. We have characterized AT gene structure and expression in the mouse species Mus caroli, which expresses high levels of AT in the kidneys as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::998676ba75aff1561da038cf72b821ee
https://doi.org/10.1128/mcb.10.2.760-769.1990
https://doi.org/10.1128/mcb.10.2.760-769.1990
Autor:
C, Fantz, D, Shaw, W, Jennings, A, Forsthoefel, M, Kitchens, J, Phan, W, Minor, L, Lebioda, F G, Berger, H T, Spencer
Publikováno v:
Molecular pharmacology. 57(2)
Drug-resistant variants of thymidylate synthase (TS) can potentially be used in gene therapy applications to decrease the myelosuppressive side effects of TS-directed anticancer agents or to select genetically modified cells in vivo. Mutations of pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b7a7fc67a03fa475bd03e4c4af2eaa88
https://pubmed.ncbi.nlm.nih.gov/10648646
https://pubmed.ncbi.nlm.nih.gov/10648646
Publikováno v:
Transgenic research. 7(6)
alpha 1-Acid glycoprotein (AGP) is an acute phase protein produced by hepatocytes. Although its exact biological function remains controversial, it was shown to protect galactosamine-sensitized or normal mice against hepatitis and lethal shock induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6a9e6ca8c2b463cc73686195cc8f6069
https://pubmed.ncbi.nlm.nih.gov/10341451
https://pubmed.ncbi.nlm.nih.gov/10341451
Publikováno v:
The Journal of biological chemistry. 274(18)
Thymidylate synthase (TS) is indispensable in the de novo synthesis of dTMP. As such, it has been an important target at which anti-neoplastic drugs are directed. The fluoropyrimidines 5-fluorouracil and 5-fluoro-2'-deoxyuridine are cytotoxic as a co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a84c743657415a5d20481288bf81a6fb
https://pubmed.ncbi.nlm.nih.gov/10212232
https://pubmed.ncbi.nlm.nih.gov/10212232
Publikováno v:
Molecular pharmacology. 48(1)
Thymidylate synthase (TS) is a homodimeric enzyme that catalyzes the reductive methylation of dUMP by N5,N10-methylene-5,6,7,8-tetrahydrofolic acid, to form dTMP. Inhibition of TS by the dUMP analog 5-fluoro-dUMP (FdUMP) occurs through the formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8776ec64829cf640ff9cd7f2237ba94a
https://pubmed.ncbi.nlm.nih.gov/7623777
https://pubmed.ncbi.nlm.nih.gov/7623777
Publikováno v:
The Journal of biological chemistry. 269(3)
Although expression of the haptoglobin (HP) as an acute phase reactant is evolutionarily conserved among mammals, there are differences among species with regard to the hormones required for stimulation. Using primary hepatocyte cultures, we show tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f45defb2b3894e524abb9ee680e7173b
https://pubmed.ncbi.nlm.nih.gov/8294478
https://pubmed.ncbi.nlm.nih.gov/8294478
Publikováno v:
Molecular pharmacology. 44(2)
A major mechanism underlying the cytotoxicity of fluoropyrimidine analogs such as 5-fluorouracil and 5-fluoro-2'-deoxyuridine (FdUrd) occurs via the formation of 5-fluoro-2'-deoxyuridylate (FdUMP), a tight-binding inhibitor of thymidylate synthase (T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::111e11c084d4be6a974e7321480c053e
https://pubmed.ncbi.nlm.nih.gov/8355668
https://pubmed.ncbi.nlm.nih.gov/8355668