Zobrazeno 1 - 10
of 44
pro vyhledávání: '"F F, Parl"'
Publikováno v:
Molecular Endocrinology. 11:1009-1019
The estrogen receptor (ER) belongs to a family of ligand-inducible nuclear receptors that exert their effects by binding to cis-acting DNA elements in the regulatory region of target genes. The detailed mechanisms by which ER interacts with the estro
Autor:
F F Parl
Publikováno v:
The Pharmacogenomics Journal. 3:251-253
Multiple mechanisms of estrogen receptor gene repression contribute to ER-negative breast cancer
Autor:
James E. Loyd, Elliott P. Dawson, John A. Phillips, James West, Lisa Wheeler, Rizwan Hamid, Lora K. Hedges, Joy D. Cogan, F. F. Parl, Eric D. Austin
Mutations in bone morphogenetic protein receptor type 2 (BMPR2) cause familial pulmonary arterial hypertension (FPAH), but the penetrance is reduced and females are significantly overrepresented. In addition, gene expression data implicating the oest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9031c81b95429ed273dad426caf74e22
https://europepmc.org/articles/PMC3742124/
https://europepmc.org/articles/PMC3742124/
Publikováno v:
Cancer research. 61(18)
The oxidative metabolism of 17beta-estradiol (E2) and estrone (E1) to catechol estrogens (2-OHE2, 4-OHE2, 2-OHE1, and 4-OHE1) and estrogen quinones has been postulated to be a factor in mammary carcinogenesis. Catechol-O-methyltransferase (COMT) cata
Publikováno v:
Cancer. 92(1)
The authors previously showed that women with a fibroadenoma have a relative risk of invasive breast carcinoma of approximately 2.0 compared with women of similar age from the general population. This relative risk approaches 1.0 when family history
Publikováno v:
Cancer research. 60(16)
Loss of expression for both the estrogen receptor-alpha and E-cadherin genes has been linked to disease progression in human ductal breast carcinomas and has been associated with aberrant 5' CpG island methylation. To assess when, during malignant pr
Publikováno v:
Cancer research. 60(13)
Activation of 17beta-estradiol (E2) through the formation of catechol estrogen metabolites, 2-OH-E2 and 4-OH-E2, and the C-16alpha hydroxylation product, 16alpha-OH-E2, has been postulated to be a factor in mammary carcinogenesis. Cytochrome P450 1B1
Publikováno v:
Cancer. 85(6)
Little information is available regarding the invasive breast carcinoma risk associated with estrogen replacement therapy (ERT) in women with histories of histologically defined breast lesions.A retrospective cohort study of a consecutive series of w
Publikováno v:
Cancer research. 58(22)
A key enzyme involved in the production of potentially carcinogenic estrogen metabolites and the activation of environmental carcinogens is cytochrome P450 1B1 (CYP1B1), the predominant member of the CYP1 family expressed in normal breast tissue and
Autor:
R G, Lapidus, S J, Nass, K A, Butash, F F, Parl, S A, Weitzman, J G, Graff, J G, Herman, N E, Davidson
Publikováno v:
Cancer research. 58(12)
Southern analysis has shown that DNA from 25% of primary estrogen receptor (ER) alpha-negative breast tumors displays aberrant methylation at one site within the ER gene CpG island. To examine more sites and increase sensitivity, we developed a methy