Zobrazeno 1 - 10
of 95
pro vyhledávání: '"F F, Kadlubar"'
Publikováno v:
Carcinogenesis. 19:1071-1076
Methyl-hydroxylated metabolites of the potent carcinogen, 7,12-dimethylbenz[a]anthracene (DMBA), namely, 7-hydroxymethyl-12-methylbenz[a]anthracene (7-OH-DMBA), 7-methyl-12-hydroxymethylbenz[a]anthracene (12-OH-DMBA) and 7,12-dihydroxymethylbenz[a]an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57c8cfde6c7d471b727949ba8fa71143
https://doi.org/10.1093/carcin/19.6.1071
https://doi.org/10.1093/carcin/19.6.1071
Publikováno v:
Carcinogenesis. 16:413-417
The role of human sulfotransferase(s) in the bioactivation of the N-hydroxy (N-OH) metabolite of the human bladder carcinogen 4-aminobiphenyl (ABP) was investigated in vitro with human tissue cytosols. Using an enzymatic assay consisting of a PAPS-re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98dd447d51cbaa549cfe03e17aead8ad
https://doi.org/10.1093/carcin/16.2.413
https://doi.org/10.1093/carcin/16.2.413
Publikováno v:
Biochemical and Biophysical Research Communications. 204:937-943
Metabolism of chloral hydrate by male B6C3F1 mouse liver microsomes generates free radical intermediate(s) as evidenced by electron spin resonance spectroscopic analysis. The subsequent induction of endogenous lipid peroxidation was shown by analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c717937e4bb6d31bd83b0c2bdb580bf0
https://doi.org/10.1006/bbrc.1994.2550
https://doi.org/10.1006/bbrc.1994.2550
Publikováno v:
Environmental toxicology and pharmacology. 4(3-4)
Gene-environment interaction is an important aspect of human cancer risk. Genetic polymorphisms in acetylation and N-oxidation have previously been described regarding their impact on the heterocyclic amine-induced risk for colon cancer. Here, we rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::029b6bbb9f62467bbda58d65a01efd92
https://pubmed.ncbi.nlm.nih.gov/21781833
https://pubmed.ncbi.nlm.nih.gov/21781833
Autor:
C B, Ambrosone, C, Sweeney, B F, Coles, P A, Thompson, G Y, McClure, S, Korourian, M Y, Fares, A, Stone, F F, Kadlubar, L F, Hutchins
Publikováno v:
Cancer research. 61(19)
The response to treatment for breast cancer is likely predicted by a number of disease and tumor tissue characteristics, many of which are under active investigation. One area that has received little attention is that of endogenous capabilities to r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::96ac3e0e1be8065bf5e0b2fc714941f0
https://pubmed.ncbi.nlm.nih.gov/11585745
https://pubmed.ncbi.nlm.nih.gov/11585745
Publikováno v:
Life sciences. 69(7)
Human cytochrome P4501A2 (CYP1A2) is involved in the metabolism of a large number of common drugs and is responsible for the metabolic activation of numerous promutagens and procarcinogens. Large interindividual differences exist in the expression of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::83bf7db96124b965ca3c185257c0288d
https://pubmed.ncbi.nlm.nih.gov/11487095
https://pubmed.ncbi.nlm.nih.gov/11487095
Publikováno v:
International journal of cancer. 95(2)
Cytochrome P450 2A6 (CYP2A6) plays an important role in the oxidation of nicotine and in the activation of tobacco-related carcinogens, such as N-nitrosodimethylamine, N-nitrosodiethylamine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone. It has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ca373563851cd485552f4771db400c9c
https://pubmed.ncbi.nlm.nih.gov/11241319
https://pubmed.ncbi.nlm.nih.gov/11241319
Autor:
C, Sweeney, G Y, McClure, M Y, Fares, A, Stone, B F, Coles, P A, Thompson, S, Korourian, L F, Hutchins, F F, Kadlubar, C B, Ambrosone
Publikováno v:
Cancer research. 60(20)
A glutathione S-transferase (GST) P1 polymorphism results in an amino acid substitution, Ile105Val; the Val-containing enzyme has reduced activity toward alkylating agents. Cancer patients with the variant enzyme may differ in removal of treatment ag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::09b163594518d1718e23f67d1d31bc2c
https://pubmed.ncbi.nlm.nih.gov/11059750
https://pubmed.ncbi.nlm.nih.gov/11059750
Autor:
L T, Frame, S, Ozawa, S A, Nowell, H C, Chou, R R, DeLongchamp, D R, Doerge, N P, Lang, F F, Kadlubar
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 28(9)
A thermostable phenol sulfotransferase, SULT1A1, has been implicated in numerous detoxification and bioactivation pathways; however, little is known regarding its endogenous function or its putative role in mediating risk for human environmental dise
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::40f3ba66389aa4bcadda3356614d879e
https://pubmed.ncbi.nlm.nih.gov/10950850
https://pubmed.ncbi.nlm.nih.gov/10950850
Publikováno v:
Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 9(6)
Esophageal cancer, which is prevalent in China, is believed to be induced by environmental carcinogens such as nitrosamines and other agents. The disproportionate geographical distribution of this cancer among individuals suggests a role for gene-env
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b9b637e0eab5dc03b891b64063af74b8
https://pubmed.ncbi.nlm.nih.gov/10868687
https://pubmed.ncbi.nlm.nih.gov/10868687