Zobrazeno 1 - 10
of 20
pro vyhledávání: '"F E Cash"'
Publikováno v:
Journal of Molecular Biology. 226:609-621
In the present study we investigate the impact of highly stable coding region secondary structures on mRNA translation efficiency. By introducing antisense segments into the 3′ non-translated region of human α-globin mRNA we are able to synthesize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d86f17f5b3b8b1b28d609b7d5359806
https://doi.org/10.1016/0022-2836(92)90619-u
https://doi.org/10.1016/0022-2836(92)90619-u
Publikováno v:
Blood. 79:2471-2474
Human alpha-globin is encoded by two adjacent genes, alpha 2 and alpha 1. Despite their remarkable level of structural identity, the more 5′ (alpha 2) gene is the major alpha-globin locus in the normal adult, expressed at 2.6-fold higher levels tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57a0075d9478a1f6ba0149f741768a95
https://doi.org/10.1182/blood.v79.9.2471.2471
https://doi.org/10.1182/blood.v79.9.2471.2471
Autor:
MB Coleman, JG Adams, Stephen A. Liebhaber, F E Cash, A Pressley, T Sanguansermsri, Martin H. Steinberg, Ingrid Weiss
Publikováno v:
Blood. 76:2630-2636
Hemoglobin (Hb) Suan-Dok (alpha 109Arg) is a rare alpha-globin structural mutation that is linked to an alpha-thalassemia (alpha-thal) determinant. When inherited in trans to an alpha-thal-1 mutation (-), it results in Hb H disease associated with lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c649a647ea8e024cd06cae96a79a9e8
https://doi.org/10.1182/blood.v76.12.2630.bloodjournal76122630
https://doi.org/10.1182/blood.v76.12.2630.bloodjournal76122630
Autor:
Stephen A. Liebhaber, Ingrid Weiss, Annette Pressley, Mary B. Coleman, Junius G. Adams, T Sanguansermsri, Martin H. Steinberg, F E Cash
Publikováno v:
Blood. 76:2630-2636
Hemoglobin (Hb) Suan-Dok (alpha 109Arg) is a rare alpha-globin structural mutation that is linked to an alpha-thalassemia (alpha-thal) determinant. When inherited in trans to an alpha-thal-1 mutation (-), it results in Hb H disease associated with lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d135c70bb0bf16f24898cfcbe890a89
https://doi.org/10.1182/blood.v76.12.2630.2630
https://doi.org/10.1182/blood.v76.12.2630.2630
Globin gene switching is a well-described model of eucaryotic developmental control. In the case of the human alpha-globin gene cluster, migration of erythropoietic activity from the embryonic yolk sac to the fetal liver is parallaled by the zeta-glo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b2c90b8b1f84cdb878d421ed81207c
https://europepmc.org/articles/PMC231254/
https://europepmc.org/articles/PMC231254/
Publikováno v:
Blood. 79(9)
Human alpha-globin is encoded by two adjacent genes, alpha 2 and alpha 1. Despite their remarkable level of structural identity, the more 5' (alpha 2) gene is the major alpha-globin locus in the normal adult, expressed at 2.6-fold higher levels than
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c2ce0f07d80517cac58d9e27bac15dc4
https://pubmed.ncbi.nlm.nih.gov/1571559
https://pubmed.ncbi.nlm.nih.gov/1571559
Autor:
E. Paglietti, Stephen A. Liebhaber, Mario Pirastu, Renzo Galanello, Angela Loi, Luísa Romão, Ingrid Weiss, Panos Ioannou, Antonio Cao, F E Cash
Publikováno v:
Human Genetics. 89
The high level expression of the human alpha-globin genes in erythroid tissue appears to require a set of DNaseI hypersensitive sites located upstream of the human alpha-globin gene cluster. These sequences, termed the locus control region (LCR), inc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d57066a0e7e6928b04e2eba3cad68d2
https://doi.org/10.1007/bf00220551
https://doi.org/10.1007/bf00220551
Autor:
I, Weiss, F E, Cash, M B, Coleman, A, Pressley, J G, Adams, T, Sanguansermsri, S A, Liebhaber, M H, Steinberg
Publikováno v:
Blood. 76(12)
Hemoglobin (Hb) Suan-Dok (alpha 109Arg) is a rare alpha-globin structural mutation that is linked to an alpha-thalassemia (alpha-thal) determinant. When inherited in trans to an alpha-thal-1 mutation (-), it results in Hb H disease associated with lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::3d034c93f7e316a6b001098e4456745d
https://pubmed.ncbi.nlm.nih.gov/2265255
https://pubmed.ncbi.nlm.nih.gov/2265255
Synthesis of normal human hemoglobin A, alpha 2 beta 2, is based upon balanced expression of genes in the alpha-globin gene cluster on chromosome 16 and the beta-globin gene cluster on chromosome 11. Full levels of erythroid-specific activation of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::802d5395fc257574cfcf3e2dc96df516
https://europepmc.org/articles/PMC55179/
https://europepmc.org/articles/PMC55179/
Publikováno v:
Journal of Clinical Investigation. 76:1057-1064
alpha-Globin is encoded by the two adjacent genes, alpha 1 and alpha 2. Although it is clearly established that both alpha-globin genes are expressed, their relative contributions to alpha-globin messenger RNA (mRNA) and protein synthesis are not ful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4df7d4d96db41d6aeaff3f245f56fb82
https://doi.org/10.1172/jci112058
https://doi.org/10.1172/jci112058