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Effect of encainide, ODE, MODE, and flecainide on ADP/5-HT Induced platelet aggregation and in the anesthetized dog coronary artery stenosis-occlusion model of intravascular thrombosis

Autor: F D Yocca, M J Antonaccio, J S Fleming, L G Iben, J O Buchanan

Publikováno v: Cardiovascular Drugs and Therapy. 5:763-768

Encainide is a class 1C antiarrhythmic agent that is indicated for the treatment of life-threatening arrhythmias, such as sustained ventricular tachycardia. Furthermore, encainide possesses a moderate degree of antiserotonin activity, which was quant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13fac7684166b92968a697c430999c84
https://doi.org/10.1007/bf03029752

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Differential effects of coadministration of fluoxetine and WAY-100635 on serotonergic neurotransmission in vivo: sensitivity to sequence of injections

Autor: M T, Taber, G G, Kinney, R L, Pieschl, F D, Yocca, V K, Gribkoff

Publikováno v: Synapse (New York, N.Y.). 38(1)

Serotonin 5-HT(1A) receptor antagonists potentiate the effects of serotonin reuptake inhibitors on extracellular serotonin levels in a variety of brain regions. These effects are quite variable, however, with reports indicating potentiations of anywh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::3b6f02f67c8f01376dbe31e9006561b7
https://pubmed.ncbi.nlm.nih.gov/10941137

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Lack of 5-hydroxytryptamine1A-mediated inhibition of adenylyl cyclase in dorsal raphe of male and female rats

Autor: W P, Clarke, F D, Yocca, S, Maayani

Publikováno v: The Journal of pharmacology and experimental therapeutics. 277(3)

In the rat hippocampus, 5-hydroxytryptamine (5-HT)1A receptors couple to two independent effector mechanisms, the inhibition of adenylyl cyclase activity and the opening of a K+ channel. In the dorsal raphe, 5-HT1A receptors also open K+ channels; ho

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5507177486b5a206a1e8b2c1c9ab238f
https://pubmed.ncbi.nlm.nih.gov/8667186

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Pharmacology and neurochemistry of nefazodone, a novel antidepressant drug

Autor: D P, Taylor, R B, Carter, A S, Eison, U L, Mullins, H L, Smith, J R, Torrente, R N, Wright, F D, Yocca

Publikováno v: The Journal of clinical psychiatry. 56

Nefazodone is a new antidepressant drug with a pharmacologic profile distinct from that of the tricyclic, monoamine oxidase inhibitor, and serotonin selective reuptake inhibitor antidepressants. Nefazodone was initially discovered for its ability to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a24703f4414a9c98217dbd5e7ef1daa2
https://pubmed.ncbi.nlm.nih.gov/10817110

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A role for sigma binding in the antipsychotic profile of BMY 14802?

Autor: D P, Taylor, M S, Eison, S L, Moon, R F, Schlemmer, U A, Shukla, C P, VanderMaelen, F D, Yocca, D J, Gallant, S H, Behling, C G, Boissard

Publikováno v: NIDA research monograph. 133

BMY 14802 was identified as a potential antipsychotic drug in traditional model systems, and this identification was confirmed in modern behavioral and electrophysiological systems. The drug appears to be atypical as an antipsychotic in its lack of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c49997f6f4233d2d1becaca1b38cc44e
https://pubmed.ncbi.nlm.nih.gov/8232511

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Allosteric interactions between the binding sites of receptor agonists and guanine nucleotides: a comparative study of the 5-hydroxytryptamine1A and adenosine A1 receptor systems in rat hippocampal membranes

Autor: C D, Mahle, H L, Wiener, F D, Yocca, S, Maayani

Publikováno v: The Journal of pharmacology and experimental therapeutics. 263(3)

The ternary complex formed between agonist, receptor and guanine nucleotide binding protein and its destabilization by guanine nucleotides (GN) was utilized to study early events in signal transduction, by characterizing the allosteric interactions b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::80689cd1ffca9ec8aec819f04027ba3c
https://pubmed.ncbi.nlm.nih.gov/1469633

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Lack of apparent receptor reserve at postsynaptic 5-hydroxytryptamine1A receptors negatively coupled to adenylyl cyclase activity in rat hippocampal membranes

Autor: F D, Yocca, L, Iben, E, Meller

Publikováno v: Molecular pharmacology. 41(6)

Previous studies have demonstrated the existence of a large receptor reserve for agonists at somatodendritic 5-hydroxytryptamine1A (5-HT1A) serotonin receptors in the raphe nuclei of the rat. 5-HT1A agonists with anxiolytic properties (e.g., buspiron

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9060355e98ad84db5182c5fa7f33991f
https://pubmed.ncbi.nlm.nih.gov/1352034

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Nefazodone: preclinical pharmacology of a new antidepressant

Autor: A S, Eison, M S, Eison, J R, Torrente, R N, Wright, F D, Yocca

Publikováno v: Psychopharmacology bulletin. 26(3)

Recent pharmacologic studies suggest that nefazodone may possess antidepressant activity. Nefazodone is active in behavioral models predictive of antidepressant potential. It is active in reversing learned helplessness, prevents reserpine-induced pto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ada9e71886a52e710150d87519de6c39
https://pubmed.ncbi.nlm.nih.gov/2274630

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