Výsledky vyhledávání - "F D Tattersall"

Opportunities for the replacement of animals in the study of nausea and vomiting

Autor: F D Tattersall, Qasim Aziz, Anthony M. Holmes, P. L. R. Andrews, John A. Rudd

Publikováno v: British Journal of Pharmacology. 157:865-880

Nausea and vomiting are among the most common symptoms encountered in medicine as either symptoms of disease or side effects of treatments. Developing novel anti-emetics and identifying emetic liability in novel chemical entities rely on models that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::082c57cdef0230ae7d75b2ba62baa1b7
https://doi.org/10.1111/j.1476-5381.2009.00176.x

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An Inverse Agonist Selective for α5 Subunit-Containing GABAA Receptors Enhances Cognition

Autor: Neil Collinson, B. J. Everitt, Guy R. Seabrook, Keith A. Wafford, F. D. Tattersall, David S. Reynolds, M. Cobain, W. Rycroft, Angus Murray Macleod, Hedaythul Choudhury, John R. Atack, Goplan V. Pillai, Gerard R. Dawson, L. M. McDonald, Alison J. Smith, F. Sternfeld, Karen A. Maubach

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 316:1335-1345

Alpha5IA is a compound that binds with equivalent subnanomolar affinity to the benzodiazepine (BZ) site of GABA(A) receptors containing an alpha1, alpha2, alpha3, or alpha5 subunit but has inverse agonist efficacy selective for the alpha5 subtype. As

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9974698d763c91ef244a0d03e364dfbb
https://doi.org/10.1124/jpet.105.092320

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The anticonvulsant and behavioural profile of L-687,414, a partial agonist acting at the glycine modulatory site on the N-methyl-D-aspartate (NMDA) receptor complex

Autor: L. Singh, Linda J. Bristow, Paul D. Leeson, Brian John Williams, Peter H. Hutson, Mark D. Tricklebank, F. D. Tattersall, Michael Rowley, L. Thorn, K. L. Saywell

Publikováno v: British Journal of Pharmacology. 113:729-736

1. The anticonvulsant and behavioural effects of the glycine/NMDA receptor partial agonist, L-687,414 (R(+)-cis-beta-methyl-3-amino-1-hydroxypyrrolid-2-one) have been investigated in rodents. 2. L-687,414 dose-dependently antagonized seizures induced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0008ac0b50d7ca3fca8462b14ada314
https://doi.org/10.1111/j.1476-5381.1994.tb17054.x

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Discriminative stimulus effects of tiagabine and related GABAergic drugs in rats

Autor: L.M. McDonald, S. M. Staveley, Peter H. Hutson, F. D. Tattersall, W. F. Sheppard, B. Sohal

Publikováno v: Psychopharmacology. 197(4)

Rationale Tiagabine is an anticonvulsant drug which may also have sleep-enhancing properties. It acts by inhibiting reuptake at the gamma-aminobutyric acid (GABA) transporter (GAT-1). Objectives The aim of the study was to determine whether tiagabine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16d8e0e8f7849bc72fafd56b0c1702e
https://pubmed.ncbi.nlm.nih.gov/18264695

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