Zobrazeno 1 - 10
of 11
pro vyhledávání: '"F D Lott"'
Autor:
F D Lott, M R Littner
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 149:867-872
Activation of neutrophils may contribute to lung injury in the adult respiratory distress syndrome. We added rabbit neutrophils to the pulmonary circulation of salt-perfused and ventilated isolated rabbit lungs. These neutrophils were activated by ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc24a8429049ca405f44193cf50bfe6b
https://doi.org/10.1164/ajrccm.149.4.8143048
https://doi.org/10.1164/ajrccm.149.4.8143048
Publikováno v:
Pharmaceutical research. 11(8)
Two powder formulations (MMAD4 microns) containing rhG-CSF were insufflated (IF) via an endotracheal tube at doses of 5, 75 or 500 micrograms/kg to New Zealand white rabbits. Doses of 5 and 500 micrograms/kg of solutions were administered by intratra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d0890193c7dfb0ac42f9b9c3db4119a2
https://pubmed.ncbi.nlm.nih.gov/7971709
https://pubmed.ncbi.nlm.nih.gov/7971709
Autor:
F. D. Lott, M. R. Littner
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 76(4)
Studies suggest that pulmonary and neutrophil cyclooxygenase and lipoxygenase products (i.e., eicosanoids) play a role in oxidant lung injury. We tested the hypothesis that such eicosanoids contribute to lung injury from activation of rabbit neutroph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c123e15d87db6e7aab74d2d5bbe7393
https://pubmed.ncbi.nlm.nih.gov/8045846
https://pubmed.ncbi.nlm.nih.gov/8045846
Publikováno v:
Pharmaceutical research. 10(11)
Recombinant methionyl human granulocyte colony stimulating factor (G-CSF), a molecule of 18.8 kDa, has been shown to induce a systemic response after delivery by aerosol. In this work, rate and extent of absorption as well as the response were determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::de30682de8cc29fdb5978b792ac17143
https://pubmed.ncbi.nlm.nih.gov/7507241
https://pubmed.ncbi.nlm.nih.gov/7507241
Autor:
M. R. Littner, F. D. Lott
Publikováno v:
Journal of Applied Physiology. 67:846-855
We infused A23187, a calcium ionophore, into the pulmonary circulation of dextran-salt-perfused isolated rabbit lungs to release endogenous arachidonic acid. This led to elevations in pulmonary arterial pressure and to pulmonary edema as measured by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c5896dad9147f1c1efb8347e80d3f27
https://doi.org/10.1152/jappl.1989.67.2.846
https://doi.org/10.1152/jappl.1989.67.2.846
Publikováno v:
Prostaglandins, Leukotrienes and Medicine. 15:53-68
We examined the hypothesis that arachidonic acid can lead to pulmonary edema, increased pulmonary vascular permeability, and increased pulmonary vascular resistance (PVR) in an isolated dog lung. The lung was perfused with a dextran-salt solution to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9521e08a67156871773e177fdf890e18
https://doi.org/10.1016/0262-1746(84)90056-8
https://doi.org/10.1016/0262-1746(84)90056-8
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 242(3)
The authors gave infusions of exogenous arachidonic acid (AA), exogenous phospholipase A2 (PLA2) or A23187 into the pulmonary circulation of isolated salt-perfused rabbit lungs. Exogenous PLA2 and A23187 are agents that release the AA that is usually
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::05c1c55ad5cd225eb60d7b0c2f24ff8d
https://pubmed.ncbi.nlm.nih.gov/3116202
https://pubmed.ncbi.nlm.nih.gov/3116202
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 63(1)
We infused exogenous arachidonic acid (AA) into salt-perfused isolated dog lungs. This led to elevations in adenosine 3′,5′-cyclic monophosphate (cAMP) which were from conversion of the AA to cyclooxygenase products. The maximal levels of cAMP oc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e50e0dcac051ed5a22a64899bb05f3
https://pubmed.ncbi.nlm.nih.gov/3040660
https://pubmed.ncbi.nlm.nih.gov/3040660
Publikováno v:
Journal of applied physiology (Bethesda, Md. : 1985). 61(3)
Arachidonic acid metabolism can lead to synthesis of cyclooxygenase products in the lung as indicated by measurement of such products in the perfusate of isolated lungs perfused with a salt solution. However, a reduction in levels of cyclooxygenase p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::071fae92f244686e7ad94f5cddb843ae
https://pubmed.ncbi.nlm.nih.gov/3093457
https://pubmed.ncbi.nlm.nih.gov/3093457
Publikováno v:
Prostaglandins, leukotrienes, and medicine. 9(3)
In 35 isolated dog lung preparations, the pulmonary circulation of the right lung was completely separated from that of the left so that 1 lung of each preparation could serve as a control. The lungs were ventilated with 14% O 2 , 6% CO 2 and 80% N 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a2d05abb8a0268710710c49d8b54cdb
https://pubmed.ncbi.nlm.nih.gov/6291063
https://pubmed.ncbi.nlm.nih.gov/6291063