Výsledky vyhledávání - "F D, Pinkerton"

Akademický článek

Inhibitors of sterol synthesis. Metabolism-based design and construction of a new analog of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one and its effects in cultured mammalian cells and in rats.

Autor: S Swaminathan, A U Siddiqui, N Gerst, F D Pinkerton, A Kisic, L J Kim, W K Wilson, G J Schroepfer

Publikováno v: Journal of Lipid Research, Vol 36, Iss 4, Pp 767-786 (1995)

3 beta-Hydroxy-5 alpha-cholest-8(14)-en-15-one (I) is a potent regulator of cholesterol metabolism. In the present study, the 7 alpha-methyl-25,26,26,26,27,27,27-heptafluoro analog (X) of I has been synthesized with the goal of blocking not only the

Externí odkaz: https://doaj.org/article/da084ab5e6bb499282dec20b4db42a7f

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Akademický článek

Inhibitors of sterol synthesis. Effects of a new fluorinated analog of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one in rats.

Autor: N Gerst, F D Pinkerton, A Kisic, W K Wilson, S Swaminathan, G.J. Schroepfer, Jr.

Publikováno v: Journal of Lipid Research, Vol 35, Iss 6, Pp 1040-1056 (1994)

3 beta-Hydroxy-25,26,26,26,27,27,27-heptafluoro-5 alpha-cholest-8(14)-en-15-one (VII), an analog of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one (I) in which conversion to 26- and 25-oxygenated metabolites is blocked by the F7-substitution, was adm

Externí odkaz: https://doaj.org/article/2c16c45b46f44d07b2389c8a9e01ab4c

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Akademický článek

Inhibitors of sterol synthesis. Chemical synthesis of 5 beta-cholest-8-ene-3 beta,15 alpha-diol and its effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in CHO-K1 cells.

Autor: W K Wilson, F D Pinkerton, N D Kirkpatrick, G J Schroepfer, Jr

Publikováno v: Journal of Lipid Research, Vol 30, Iss 6, Pp 919-928 (1989)

5 beta-Cholest-8-ene-3 beta,15 alpha-diol, prepared by hydroboration of 5 beta-cholesta-8,14-dien-3 beta-ol, was determined to have the 14 alpha-H,15 alpha-OH configuration by comparisons of observed and calculated lanthanide-induced shifts for the 3

Externí odkaz: https://doaj.org/article/53555a0c79d34754a030d2a0f583796d

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Akademický článek

Inhibitors of sterol synthesis. Chemical synthesis, structure, and biological activities of (25R)-3 beta,26-dihydroxy-5 alpha-cholest-8(14)-en-15-one, a metabolite of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one.

Autor: H S Kim, W K Wilson, D H Needleman, F D Pinkerton, D K Wilson, F A Quiocho, G J Schroepfer, Jr

Publikováno v: Journal of Lipid Research, Vol 30, Iss 2, Pp 247-261 (1989)

3 beta-Hydroxy-5 alpha-cholest-8(14)-en-15-one (I) is a potent inhibitor of sterol synthesis with significant hypocholesterolemic activity. (25R)-3 beta,26-Dihydroxy-5 alpha-cholest-8(14)-en-15-one (II) has been shown to be a major metabolite of I af

Externí odkaz: https://doaj.org/article/8f8985ab75134d23853f8a93bc6f2786

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Sterols in blood of normal and Smith-Lemli-Opitz subjects

Autor: B, Ruan, W K, Wilson, J, Pang, N, Gerst, F D, Pinkerton, J, Tsai, R I, Kelley, F G, Whitby, D M, Milewicz, J, Garbern, G J, Schroepfer

Publikováno v: Journal of lipid research. 42(5)

Smith-Lemli-Opitz syndrome (SLOS) is a hereditary disorder in which a defective gene encoding 7-dehydrocholesterol reductase causes the accumulation of noncholesterol sterols, such as 7- and 8-dehydrocholesterol. Using rigorous analytical methods in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6839319f44fd8b5e07b3652540e12831
https://pubmed.ncbi.nlm.nih.gov/11352988

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Inhibitors of sterol synthesis. Synthesis and spectral properties of 3 beta-hydroxy-5 alpha-cholestan-15-one and its 17 beta-epimer and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity

Autor: A U, Siddiqui, W K, Wilson, E J, Parish, N, Gerst, F D, Pinkerton, G J, Schroepfer

Publikováno v: Chemistry and physics of lipids. 74(1)

3 beta-Hydroxy-5 alpha-cholestan-15-one (2a) and its 14 beta-epimer 2b were prepared from 3 beta-acetoxy-5 alpha-cholest-8(14)-ene (3). Hydroboration of 3 at 45-50 degrees C gave a mixture of 5 alpha,14 alpha-cholestane-3 beta,15 alpha-diol and 5 alp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::effa39a922fac760b267de468e8dc467
https://pubmed.ncbi.nlm.nih.gov/7820900

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Inhibitors of sterol synthesis. Submicromolar 14 alpha-ethyl-5 alpha-cholest-7-ene-3 beta, 15 alpha-diol causes a major modification of the sterol composition of CHO-K1 cells and a marked change in cell morphology

Autor: A, Izumi, F D, Pinkerton, S O, Nelson, J S, Pyrek, P J, Neill, J H, Smith, G J, Schroepfer

Publikováno v: Journal of lipid research. 35(7)

Incubation of Chinese hamster ovary cells (CHO-K1) with 14 alpha-ethyl-5 alpha-cholest-7-ene-3 beta,15 alpha-diol (0.1 microM) in lipid-deficient medium led to a major change in cellular sterol composition, which was characterized by a very marked ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ed1de67dba755d914707451906fef883
https://pubmed.ncbi.nlm.nih.gov/7964186

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Inhibitors of sterol synthesis. Chemical synthesis and properties of 3 beta-hydroxy-25,26,26,26,27,27,27-heptafluoro-5 alpha-cholest-8(14)-en-15-one and 25,26,26,26,27,27,27-heptafluorocholesterol and their effects on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured mammalian cells

Autor: S, Swaminathan, W K, Wilson, F D, Pinkerton, N, Gerst, M, Ramser, G J, Schroepfer

Publikováno v: Journal of lipid research. 34(10)

A side-chain fluorinated delta 8(14)-15-ketosterol has been synthesized from 3 beta-acetoxy-24-hydroxy-5 alpha-chol-8(14)-en-15-one (VII) as part of a program to prepare new analogs of 3 beta-hydroxy-5 alpha-cholest-8(14)-en-15-one (I), a potent regu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a2cb0b93727767ff70d4e18f276bfa81
https://pubmed.ncbi.nlm.nih.gov/8245728

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