Výsledky vyhledávání - "F D, Boudinot"

Pharmacokinetics of the insulin-sensitizing agent troglitazone in cats

Autor: Duncan C. Ferguson, G. M. Michels, Margarethe Hoenig, F. D. Boudinot

Publikováno v: American Journal of Veterinary Research. 61:775-778

Objective—To determine pharmacokinetics of troglitazone in healthy cats after IV and oral administration of a single dose of the drug. Animals—5 healthy ovariohysterectomized adult cats. Procedure—Using a randomized crossover design, cats were

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f223d9719590b0c11714358cafd4659
https://doi.org/10.2460/ajvr.2000.61.775

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Lymphatic Targeting of Anti-Human Immunodeficiency Virus Nucleosides: Pharmacokinetics of G′-Deoxy-2′,3′-Didehydrothymidine after Intravenous and Oral Administration of Dipalmitoylphosphatidyl Prodrug to Mice

Autor: Chung K. Chu, F. D. Boudinot, Z.-S. Xu, K. K. Manouilov, L. S. Manouilova, Raymond F. Schinazi

Publikováno v: Antiviral Chemistry and Chemotherapy. 8:409-415

The lymphatic system is a primary target for early anti-human immunodeficiency virus drug therapy. Strategies are currently being sought to enhance the delivery of nucleoside analogues such as 3′-deoxy-2′,3′-didehydrothymidine (stavudine; d4T)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de04ccf5c211060b6295f5ca5919ee4a
https://doi.org/10.1177/095632029700800503

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High-performance liquid chromatographic determination of (−)-β-d-2-aminopurine dioxolane and (−)-β-d-2-amino-6-chloropurine dioxolane, and their metabolite (−)-β-d-dioxolane guanine in monkey serum, urine and cerebrospinal fluid

Autor: Harold M. McClure, Raymond F. Schinazi, K. K. Manouilov, F. D. Boudinot, Huizhong Chen, Chung K. Chu

Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 691:425-432

(−)-β- d -2-Aminopurine dioxolane (APD), (−)-β- d -2-amino-6-chloropurine dioxolane (ACPD) and dioxolane guanine (DXG) are nucleoside analogues possessing potent activity against human immunodeficiency virus (HIV) and hepatitis B virus (HBV) in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::250dfdaee4d7d6e75df221779be9f114
https://doi.org/10.1016/s0378-4347(96)00473-2

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Pharmacokinetics of (-)-beta-D-2-aminopurine dioxolane and (-)-beta-D-2-amino-6-chloropurine dioxolane and their antiviral metabolite (-)-beta-D-dioxolane guanine in rhesus monkeys

Autor: Huizhong Chen, F. D. Boudinot, R. F. Schinazi, Chung K. Chu, H M Mcclure

Publikováno v: Antimicrobial Agents and Chemotherapy. 40:2332-2336

(-)-beta-D-2-Aminopurine dioxolane (APD) and (-)-beta-D-2-amino-6-chloropurine dioxolane (ACPD) are recently synthesized dioxolanylpurine nucleoside derivatives being developed as potential prodrugs for the antiviral nucleoside analog (-)-beta-D-diox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da687217dde76246e0dcf930a3f02140
https://doi.org/10.1128/aac.40.10.2332

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Physicochemical Properties, Bioconversion and Disposition of Lipophilic Prodrugs of 2′,3′-Dideoxycytidine

Autor: Chung K. Chu, Raymond F. Schinazi, F. D. Boudinot, S. S. Ibrahim

Publikováno v: Antiviral Chemistry and Chemotherapy. 7:167-172

Lipophilic prodrugs of 2′,3′-dideoxycytidine (ddC), 4,5′-diacetyI-ddC (DAC), 4,5′-ditrimethylacetyl-ddC (DTMAC), 4,5′-dicyclopentylpropionyl-ddC (DCYPP) and 5′-cholesteryl-ddC (CHOL), were evaluated for their utility in improving brain de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa0995adc1afc3c1280ec5b016f94c20
https://doi.org/10.1177/095632029600700307

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Pharmacokinetics of (-)-β-D-2,6-Diaminopurine Dioxolane and its Metabolite, Dioxolane Guanosine, in Woodchucks (Marmota Monax)

Autor: Raymond F. Schinazi, Bud C. Tennant, F. D. Boudinot, Prabhu Rajagopalan, Baldwin Bh, Chung K. Chu

Publikováno v: Antiviral Chemistry and Chemotherapy. 7:65-70

The woodchuck ( Marmota monax) is a useful animal model for evaluating the in-vivo efficacy of antiviral agents against hepatitis B viral infection (HBV). The pharmacokinetics of a newly synthesized antiviral agent (-)-β-D-2,6-diaminopurine dioxolan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6e0761afbc08e5a39da3b4f4e54b48fe
https://doi.org/10.1177/095632029600700202

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Pharmacokinetics of (-)-2'-3'-dideoxy-3'-thiacytidine in woodchucks

Autor: R. F. Schinazi, B. H. Baldwin, Chung K. Chu, B. C. Tennant, Prabhu Rajagopalan, F. D. Boudinot

Publikováno v: Antimicrobial Agents and Chemotherapy. 40:642-645

The woodchuck (Marmota monax) has proven to be a suitable animal model for studying hepatitis B virus (HBV) infection owing to similarities in the course of infection between woodchuck hepatitis virus (WHV) in woodchucks and HBV in humans. (-)-beta-L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf60bf1026d775b36bb45c8377f8c0b
https://doi.org/10.1128/aac.40.3.642

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High-performance liquid chromatographic determination of 5-fluorouracil and its prodrugs, tegafur and 4-deoxy-5-fluorouracil, in rat plasma

Autor: V R Jarugula, F. D. Boudinot

Publikováno v: Journal of Chromatography B: Biomedical Sciences and Applications. 677:199-203

A rapid, sensitive and reproducible ion-pair, reversed-phase high-performance liquid chromatographic (HPLC) method was developed to simultaneously quantitate 5-fluorouracil (5FU) and its prodrugs, tegafur (TF) and 4-deoxy-5-fluorouracil (DFU), in rat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8718b33fff6f21ab102705b21fefb348
https://doi.org/10.1016/0378-4347(95)00438-6

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[Untitled]

Autor: J W Witcher, F. D. Boudinot

Publikováno v: Pharmaceutical Research. 13:1720-1724

Purpose. To illustrate the application of a discontinuous oral absorption model to cimetidine and ranitidine plasma concentration versus time data to demonstrate the use of the model for drugs which display discontinuous oral absorption profiles, and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80a3ad3a61d8bd1416a449a25ba06bf4
https://doi.org/10.1023/a:1016457110726

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