Výsledky vyhledávání

General medical conditions in 347 bipolar disorder patients: Clinical correlates of metabolic and autoimmune-allergic diseases

Autor: Giuseppe Quaranta, Cristina Toni, F Casalini, N Mosti, Liliana Dell'Osso, Giulio Perugi, Serena Belletti

Publikováno v: Journal of Affective Disorders. 170:95-103

Background Patients with bipolar disorder (BD) suffer from greater physical morbidity and mortality than the general population. The aim of the present study is to explore the prevalence and clinical correlates of General Medical Conditions (GMC) in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::340117be074c15096e16901dcf02b104
https://doi.org/10.1016/j.jad.2014.08.052

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Unplanned readmissions within 30 days after discharge: improving quality through easy prediction

Autor: Pier Luigi Lopalco, Elena Lucaccini, Silvia Memmini, F Casalini, Gabriele Massimetti, Susanna Salvetti, Gaetano Pierpaolo Privitera

Publikováno v: International journal for quality in health care : journal of the International Society for Quality in Health Care. 29(2)

Objective To propose an easy predictive model for the risk of rehospitalization, built from hospital administrative data, in order to prevent repeated admissions and to improve transitional care. Design Retrospective cohort study. Setting Azienda Osp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5160afaafc190ee23597567c4628e4e
https://pubmed.ncbi.nlm.nih.gov/28453826

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Identification of novel molecular scaffolds for the design of MMP-13 inhibitors: A first round of lead optimization

Autor: Valeria La Pietra, Sabrina Taliani, Hideaki Nagase, Elisa Nuti, Robert Visse, Federico Da Settimo, Francesco Saverio Di Leva, Ettore Novellino, Luciana Marinelli, Concettina La Motta, Salvatore Santamaria, Sandro Cosconati, Matteo Morelli, Armando Rossello, F Casalini, Isabella Pugliesi

Publikováno v: European Journal of Medicinal Chemistry. 47:143-152

Osteoarthritis (OA) is the leading cause of joint pain and disability in middle-aged and elderly patients, and is characterized by progressive loss of articular cartilage. Among the various matrix metalloproteinases (MMPs), MMP-13 is specifically exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7777138b02eecc0f72860ec171aadc0
https://doi.org/10.1016/j.ejmech.2011.10.035

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Synthesis and biological evaluation in U87MG glioma cells of (ethynylthiophene)sulfonamido-based hydroxamates as matrix metalloproteinase inhibitors

Autor: Barbara Costa, Salvatore Santamaria, Luciana Marinelli, Elisa Nuti, Eleonora Da Pozzo, P Gabelloni, Valeria La Pietra, Federico Da Settimo, Armando Rossello, Rafael Fridman, S Bendinelli, F Casalini, Claudia Martini, M. Margarida Bernardo, Ettore Novellino

Publikováno v: European Journal of Medicinal Chemistry. 46:2617-2629

Matrix metalloproteinases (MMPs) are important factors in gliomas since these enzymes facilitate invasion into the surrounding brain and participate in neovascularization. In particular, the gelatinases (MMP-2 and MMP-9), and more recently MMP-25, ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e6183930dedf0a4dbb8e0766edeffb1
https://doi.org/10.1016/j.ejmech.2011.03.033

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Design, Synthesis, Biological Evaluation, and NMR Studies of a New Series of Arylsulfones As Selective and Potent Matrix Metalloproteinase-12 Inhibitors

Autor: Laura Panelli, Elisabetta Orlandini, Salvatore Santamaria, Elisa Nuti, Stanislava Ivanova Avramova, Nicola D'Amelio, Alessandro Maiocchi, Tiziano Tuccinardi, Fulvio Uggeri, F Casalini, Armando Rossello, Giovanni Cercignani, Adriano Martinelli, Susanna Nencetti

Publikováno v: Journal of Medicinal Chemistry. 52:6347-6361

Overexpression of macrophage elastase (MMP-12), a member of the matrix metalloproteinases family, can be linked to tissue remodeling and degradation in some inflammatory processes, such as chronic obstructive pulmonary disease (COPD), emphysema, rheu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92091eb0f92cc42942bcd11ee2676f01
https://doi.org/10.1021/jm900335a

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Colonization by Legionella spp. of water networks in residential buildings of the Province of Pisa, Italy

Autor: A, Baggiani, B, Casini, M, Totaro, F, Aquino, P, Valentini, B, Bruni, A, Porretta, F, Casalini, M, Miccoli, G, Privitera

Despite the increase of community acquired cases of legionellosis in Italy over the last years, the Italian guidelines do not give indications for prevention and control of Legionella in the hot water networks (or centralized conditioning systems) of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ab0c1a052ada838f5f35d04003f59fca
http://hdl.handle.net/11568/762321

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Study of the binding interaction between fluorinated matrix metalloproteinase inhibitors and Human Serum Albumin

Autor: Carlos F. G. C. Geraldes, Tiziano Tuccinardi, David M. Dias, F Casalini, Alessandro Maiocchi, Armando Rossello, Claudio Cassino, Valeria Catanzaro, Giuseppe Digilio

Publikováno v: European journal of medicinal chemistry. 79

Fluorinated, arylsulfone-based inhibitors of Matrix Metalloproteinases (MMP) have been used, in the [ 18 F]-radiolabelled version, as radiotracers targeted to MMP-2/9 for Positron Emission Tomography (PET). Although they showed acceptable tumour upta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1da553b42bc70ace118ee89dd1472c
https://pubmed.ncbi.nlm.nih.gov/24704692

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Selective arylsulfonamide inhibitors of ADAM-17: hit optimization and activity in ovarian cancer cell models

Autor: F Casalini, Ettore Novellino, Salvatore Santamaria, Silvano Ferrini, Marina Fabbi, Elisabetta Orlandini, Elisa Nuti, Susanna Nencetti, Armando Rossello, Luciana Marinelli, Caterina Camodeca, Valeria La Pietra, Grazia Carbotti

Publikováno v: Journal of medicinal chemistry. 56(20)

Activated leukocyte cell adhesion molecule (ALCAM) is expressed at the surface of epithelial ovarian cancer (EOC) cells and is released in a soluble form (sALCAM) by ADAM-17-mediated shedding. This process is relevant to EOC cell motility and invasiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4893e93619efea4483d48ae09bb4a850
https://pubmed.ncbi.nlm.nih.gov/24044434

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Potent arylsulfonamide inhibitors of tumor necrosis factor-alpha converting enzyme able to reduce activated leukocyte cell adhesion molecule shedding in cancer cell models

Autor: Salvatore Santamaria, Vittorio Limongelli, Susanna Nencetti, F Casalini, Ettore Novellino, Armando Rossello, Luciana Marinelli, Valeria La Pietra, Stanislava Ivanova Avramova, Elisabetta Orlandini, Elisa Nuti, Silvano Ferrini, Giovanni Cercignani, Marina Fabbi

Publikováno v: Journal of medicinal chemistry. 53(6)

Activated leukocyte cell adhesion molecule (ALCAM) plays a relevant role in tumor biology and progression. Our previous studies showed that ALCAM is expressed at the surface of epithelial ovarian cancer (EOC) cells and is released in a soluble form b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::410ead2997deec12d88e5d43dba639d7
https://pubmed.ncbi.nlm.nih.gov/20180536

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