Výsledky vyhledávání - "F C, Richardson"

Incorporation of fialuridine (FIAU) into mitochondrial DNA and effects of FIAU on the morphology of mitochondria in human hepatoblastoma cells

Autor: D. M. Horn, J.W. Horn, F. C. Richardson, J. M. Colacino

Publikováno v: Toxicology in Vitro. 10:297-303

Fialuridine (FIAU), a thymidine nucleoside analogue with anti-hepatitis B virus activity, showed clinical toxicity consistent with mitochondrial dysfunction. In vitro methods were used to understand further this toxicity. Using a sensitive and specif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96e7c892cdacad9f8a92ef9c533cb818
https://doi.org/10.1016/0887-2333(96)00016-1

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Dose-Dependent Induction of GST-P+Staining Foci by the Rat Hepatocarcinogen Methapyrilene in the Medium-Term Bioassay

Autor: D M, Horn, W H, Jordan, D C, Holloway, W C, Smith, F C, Richardson

Publikováno v: Fundamental and Applied Toxicology. 29:194-197

Previous studies have demonstrated that methapyrilene hydrochloride (MP) is a rat-specific nongenotoxic carcinogen which induces liver tumors in a dose-dependent manner following chronic exposure in the diet. This study was conducted to determine the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96cd3211aaa35190fc21c89aa8c893a3
https://doi.org/10.1006/faat.1996.0021

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Radionavigation in the UK in World War II

Autor: F. C. Richardson

Publikováno v: Journal of Navigation. 45:60-69

This paper, and the following one, were originally presented at an Institute afternoon meeting held at the RAF Museum, Hendon, on 5 June 1991. This first paper gives a personal view of the development and use of radionavigation techniques in the UK i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0db0c85e14500d86293ff68bd56aec9d
https://doi.org/10.1017/s037346330001047x

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Antitumor efficacy, pharmacokinetics, and biodistribution of NX 211: a low-clearance liposomal formulation of lurtotecan

Autor: D L, Emerson, R, Bendele, E, Brown, S, Chiang, J P, Desjardins, L C, Dihel, S C, Gill, M, Hamilton, J D, LeRay, L, Moon-McDermott, K, Moynihan, F C, Richardson, B, Tomkinson, M J, Luzzio, D, Baccanari

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 6(7)

Lurtotecan is a clinically active water-soluble camptothecin analogue that has been formulated into a low-clearance unilamellar liposome, NX 211. Comparative studies between free drug and NX 211 have been performed assessing pharmacokinetics in nude

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::abc9e48a0e7831ecfb80c7a78e6ebf3f
https://pubmed.ncbi.nlm.nih.gov/10914740

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Effect of a template-located 2',2'-difluorodeoxycytidine on the kinetics and fidelity of base insertion by Klenow (3'--5'exonuclease-) fragment

Autor: W E, Schy, L W, Hertel, J S, Kroin, L B, Bloom, M F, Goodman, F C, Richardson

Publikováno v: Cancer research. 53(19)

Gemcitabine [2',2'-difluorodeoxycytidine (dFdCyd)], a potent antitumor agent, inhibits DNA synthesis and is incorporated internally into DNA. The effect of a template-incorporated dFdCyd molecule (dFdCyd-) on DNA polymerase function was examined. Two

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::b7da9d6afc166bc3f22d20f74c0aad41
https://pubmed.ncbi.nlm.nih.gov/8402631

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