Zobrazeno 1 - 10
of 128
pro vyhledávání: '"F Brad Johnson"'
Autor:
Rafael Jesus Fernandez, Zachary JG Gardner, Katherine J Slovik, Derek C Liberti, Katrina N Estep, Wenli Yang, Qijun Chen, Garrett T Santini, Javier V Perez, Sarah Root, Ranvir Bhatia, John W Tobias, Apoorva Babu, Michael P Morley, David B Frank, Edward E Morrisey, Christopher J Lengner, F Brad Johnson
Publikováno v:
eLife, Vol 11 (2022)
Dyskeratosis congenita (DC) is a rare genetic disorder characterized by deficiencies in telomere maintenance leading to very short telomeres and the premature onset of certain age-related diseases, including pulmonary fibrosis (PF). PF is thought to
Externí odkaz:
https://doaj.org/article/5a2e0adc44d4496d8818d07ddfebb226
Autor:
Jennifer J Wanat, Glennis A Logsdon, Jordan H Driskill, Zhong Deng, Paul M Lieberman, F Brad Johnson
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195698 (2018)
The events underlying senescence induced by critical telomere shortening are not fully understood. Here we provide evidence that TERRA, a non-coding RNA transcribed from subtelomeres, contributes to senescence in yeast lacking telomerase (tlc1Δ). Le
Externí odkaz:
https://doaj.org/article/32ec40c3dada4fa5a41f13622e7980cf
Autor:
Elizabeth P. Crowe, Ferit Tuzer, Brian D. Gregory, Greg Donahue, Sager J. Gosai, Justin Cohen, Yuk Yee Leung, Emre Yetkin, Raffaella Nativio, Li-San Wang, Christian Sell, Nancy M. Bonini, Shelley L. Berger, F Brad Johnson, Claudio Torres
Publikováno v:
Frontiers in Aging Neuroscience, Vol 8 (2016)
Aging is a major risk factor for many neurodegenerative disorders. A key feature of aging biology that may underlie these diseases is cellular senescence. Senescent cells accumulate in tissues with age, undergo widespread changes in gene expression,
Externí odkaz:
https://doaj.org/article/3ae31c0b3bc84fef8025ad4be73ee323
Autor:
Lucie Aumailley, Chantal Garand, Marie Julie Dubois, F Brad Johnson, André Marette, Michel Lebel
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0140292 (2015)
Werner syndrome (WS) is a premature aging disorder caused by mutations in a RecQ-family DNA helicase, WRN. Mice lacking part of the helicase domain of the WRN orthologue exhibit many phenotypic features of WS, including metabolic abnormalities and a
Externí odkaz:
https://doaj.org/article/5f299a8ac4cc475fa88a79176c94215b
Autor:
Jay E Johnson, F Brad Johnson
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97729 (2014)
A methionine-restricted diet robustly improves healthspan in key model organisms. For example, methionine restriction reduces age-related pathologies and extends lifespan up to 45% in rodents. However, the mechanisms underlying these benefits remain
Externí odkaz:
https://doaj.org/article/dc7fce0ad6294d7cbc66de2b07885917
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e74578 (2013)
Several recent gene expression studies identified hundreds of genes that are correlated with age in brain and other tissues in human. However, these studies used linear models of age correlation, which are not well equipped to model abrupt changes as
Externí odkaz:
https://doaj.org/article/f37ded5f59914e12a07dab60a7c9381a
Publikováno v:
PLoS Biology, Vol 5, Iss 6, p e160 (2007)
RecQ helicases, including Saccharomyces cerevisiae Sgs1p and the human Werner syndrome protein, are important for telomere maintenance in cells lacking telomerase activity. How maintenance is accomplished is only partly understood, although there is
Externí odkaz:
https://doaj.org/article/2ca2530df61d48148591ba90ccd8dd94
Autor:
Elisia D. Tichy, Ji-Hyung Lee, Grant Li, Katrina N. Estep, F. Brad Johnson, Foteini Mourkioti
Publikováno v:
npj Microgravity, Vol 9, Iss 1, Pp 1-11 (2023)
Abstract Astronauts are exposed to harsh conditions, including cosmic radiation and microgravity. Spaceflight elongates human telomeres in peripheral blood, which shorten upon return to Earth and approach baseline levels during postflight recovery. A
Externí odkaz:
https://doaj.org/article/49296aaceaad41838d28e1fc4c254dfa
Autor:
Young-Jun Choi, Melissa S. Kim, Joshua H. Rhoades, Nicolette M. Johnson, Corbett T. Berry, Sarah Root, Qijun Chen, Yuhua Tian, Rafael J. Fernandez, III, Zvi Cramer, Stephanie Adams-Tzivelekidis, Ning Li, F. Brad Johnson, Christopher J. Lengner
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 3, Pp 451-472 (2023)
Background & Aims: Dyskeratosis congenita (DC) is a telomere biology disorder caused primarily by mutations in the DKC1 gene. Patients with DC and related telomeropathies resulting from premature telomere dysfunction experience multiorgan failure. In
Externí odkaz:
https://doaj.org/article/097aee7b209740a1bf70038743eb0b74
Autor:
Carl H. June, Michael C. Milone, Michael Kalos, Yangbing Zhao, Chrystal M. Paulos, F. Brad Johnson, Jesse M. Platt, Laurence J.N. Cooper, Sonny Ang, Avery D. Posey, Shannon E. McGettigan, Sonia Guedan, Omkar U. Kawalekar, John Scholler, Shinichiro Motohashi, Carmine Carpenito, Maria Ciocca Basil, Jihyun Lee, Matthew J. Frigault
This study compared second-generation chimeric antigen receptors (CAR) encoding signaling domains composed of CD28, ICOS, and 4-1BB (TNFRSF9). Here, we report that certain CARs endow T cells with the ability to undergo long-term autonomous proliferat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08f3bff5e6b4e8eccb2b0a30c2a678d8
https://doi.org/10.1158/2326-6066.c.6548833.v1
https://doi.org/10.1158/2326-6066.c.6548833.v1
