Zobrazeno 1 - 8
of 8
pro vyhledávání: '"F Barclay, Shilliday"'
Autor:
F. Barclay Shilliday, Allen Hilgers, J. James Vrbanac, David Humphries, Roger N. Hayes, Tyson Dubnicka
Publikováno v:
Rapid Communications in Mass Spectrometry. 26:2569-2576
RATIONALE Herein we describe a generic quantitative method using high-resolution, isotope-dilution (HRID) metabolism of isotope-labeled compounds and apply it to the analysis of drug metabolites (DMs) in human plasma. Metabolites (drug) in Safety Tes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6aeba0c10ab5f7b481dc3c941eb44055
https://doi.org/10.1002/rcm.6376
https://doi.org/10.1002/rcm.6376
Autor:
F. Barclay Shilliday, Xiaojun Fang, Chungang Gu, Daniel P. Walker, Gwendolyn D. Fate, Bruce A. Thornburgh, J. Scott Daniels
Publikováno v:
Drug Metabolism Letters. 4:163-172
The quinuclidine PHA-0568487(1) is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated liabilities with in vivo tolerability.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c4e777b592b0219f5ae9e7adaf437509
https://doi.org/10.2174/187231210791698429
https://doi.org/10.2174/187231210791698429
Autor:
Shengtian Yang, Russell H. Robins, Kathy M. Mandrell, F. Barclay Shilliday, Bruce R. Heyde, Yurong Lai, Yiding Hu, Matthew T. Reding, David C. Thompson, Jin Xie
Publikováno v:
Drug Metabolism and Disposition. 38:1522-1531
The thiophene moiety is considered a structural alert in molecular design in drug discovery, largely because several thiophene-containing drugs, including tienilic acid and suprofen, have been withdrawn from the market because of toxicities. Reactive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa079f94506b5151907c2e5f9b9baffc
https://doi.org/10.1124/dmd.110.032581
https://doi.org/10.1124/dmd.110.032581
Publikováno v:
Journal of Chromatographic Science. 39:513-520
A set of 17,600 samples belonging to our compound collection is selectively examined by liquid chromatography with UV, evaporative light scattering, and mass spectrometric detection methods. At least 70% of this set consists of pure samples with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6c696e3123df32b3ba0227899028e8c
https://doi.org/10.1093/chromsci/39.12.513
https://doi.org/10.1093/chromsci/39.12.513
Autor:
J James, Vrbanac, Allen, Hilgers, Tyson, Dubnicka, F Barclay, Shilliday, David, Humphries, Roger N, Hayes
Publikováno v:
Rapid communications in mass spectrometry : RCM. 26(22)
Herein we describe a generic quantitative method using high-resolution, isotope-dilution (HRID) metabolism of isotope-labeled compounds and apply it to the analysis of drug metabolites (DMs) in human plasma. Metabolites (drug) in Safety Testing (MIST
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7882c4ed04fc462c2b2f644f197ae889
https://pubmed.ncbi.nlm.nih.gov/23059872
https://pubmed.ncbi.nlm.nih.gov/23059872
Autor:
F Barclay, Shilliday, Daniel P, Walker, Chungang, Gu, Xiaojun, Fang, Bruce, Thornburgh, Gwendolyn D, Fate, J Scott, Daniels
Publikováno v:
Drug metabolism letters. 4(3)
The quinuclidine PHA-0568487(1) is an agonist of the alpha 7 nicotinic acetylcholine receptor that was designed to mitigate the bioactivation associated with the core scaffold and subsequently remove associated liabilities with in vivo tolerability.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cc446a287f02123b938503804a0dfbc4
https://pubmed.ncbi.nlm.nih.gov/20642449
https://pubmed.ncbi.nlm.nih.gov/20642449
In VitroMechanistic Toxicology Evaluation of the Antibiotic, Paldimycin Sodium, in Chang Liver Cells
Autor:
Daniel A. Linseman, J.A. Bacon, F. Barclay Shilliday, Kelly L. Linseman, T.J. Raczniak, Daniel G. Branstetter
Publikováno v:
Alternatives to Laboratory Animals. 20:519-528
The basal in vitro cytotoxic potential of the antibiotic, paldimycin sodium, was investigated in Chang liver cells. The potential roles of lipid peroxidation, protein binding, and proteolytic enzyme activation in the cytotoxic mechanism of paldimycin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f4ea3efa718e14d2b1630cb289319184
https://doi.org/10.1177/026119299202000404
https://doi.org/10.1177/026119299202000404
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