Zobrazeno 1 - 10 of 156 pro vyhledávání: '"F Anthony Lai"'
1
Akademický článek
Advancing male age differentially alters levels and localization patterns of PLCzeta in sperm and testes from different mouse strains
Autor: Junaid Kashir, Bhavesh V Mistry, Maha Adel Gumssani, Muhammad Rajab, Reema Abu-Dawas, Falah AlMohanna, Michail Nomikos, Celine Jones, Raed Abu-Dawud, Nadya Al-Yacoub, Kevin Coward, F Anthony Lai, Abdullah M Assiri
Publikováno v: Asian Journal of Andrology, Vol 23, Iss 2, Pp 178-187 (2021)
Sperm-specific phospholipase C zeta (PLCζ) initiates intracellular calcium (Ca2+) transients which drive a series of concurrent events collectively termed oocyte activation. Numerous investigations have linked abrogation and absence/reduction of PLC
Externí odkaz: https://doaj.org/article/1cc4546088f94a80ad9b06c67b3737c6
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2
Akademický článek
Is PAWP the 'real' sperm factor?
Autor: Michail Nomikos, Karl Swann, F Anthony Lai
Publikováno v: Asian Journal of Andrology, Vol 17, Iss 3, Pp 444-446 (2015)
Externí odkaz: https://doaj.org/article/9ad5cdeea31d455bbba2340b01ccdae8
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3
Akademický článek
Development of Recombinant PLC-Zeta Protein as a Therapeutic Intervention for the Clinical Treatment of Oocyte Activation Failure
Autor: Alaaeldin Saleh, Angelos Thanassoulas, Elnur Aliyev, Karl Swann, Azza Naija, Huseyin C. Yalcin, F. Anthony Lai, Michail Nomikos
Publikováno v: Biomedicines, Vol 12, Iss 6, p 1183 (2024)
The sperm-specific phospholipase C zeta (PLCζ) protein is widely considered as the predominant physiological stimulus for initiating the Ca2+ release responsible for oocyte activation during mammalian fertilization. The increasing number of genetic
Externí odkaz: https://doaj.org/article/1aeb2a708e144bbbbacca2653c0aedc5
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4
Akademický článek
Antigen Unmasking Is Required to Clinically Assess Levels and Localisation Patterns of Phospholipase C Zeta in Human Sperm
Autor: Junaid Kashir, Bhavesh V. Mistry, Lujain BuSaleh, Michail Nomikos, Sarah Almuqayyil, Raed Abu-Dawud, Nadya AlYacoub, Hamdan Hamdan, Saad AlHassan, F. Anthony Lai, Abdullah M. Assiri, Serdar Coskun
Publikováno v: Pharmaceuticals, Vol 16, Iss 2, p 198 (2023)
Mammalian oocyte activation is initiated by intracellular calcium (Ca2+) oscillations, driven by the testis-specific phospholipase C zeta (PLCζ). Sperm PLCζ analysis represents a diagnostic measure of sperm fertilisation capacity. The application o
Externí odkaz: https://doaj.org/article/a4ab80c5fba549ef92f4b8173307b327
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5
Defective ryanodine receptor N-terminus inter-subunit interaction is a common mechanism in neuromuscular and cardiac disorders
Autor: Yadan Zhang, Camille Rabesahala de Meritens, Astrid Beckmann, F. Anthony Lai, Spyros Zissimopoulos
Publikováno v: Frontiers in Physiology. 13
The ryanodine receptor (RyR) is a homotetrameric channel mediating sarcoplasmic reticulum Ca2+ release required for skeletal and cardiac muscle contraction. Mutations in RyR1 and RyR2 lead to life-threatening malignant hyperthermia episodes and ventr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd4f8e5deaf851e8da3fd986e5f4953
https://doi.org/10.3389/fphys.2022.1032132
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7
SPERM FACTORS AND EGG ACTIVATION: The structure and function relationship of sperm PLCZ1
Autor: Angelos Thanassoulas, Karl Swann, F Anthony Lai, Michail Nomikos
Publikováno v: Reproduction (Cambridge, England). 164(1)
In 2002, sperm-specific phospholipase C zeta1 (PLCZ1) was discovered and through these 20 years, it has been established as the predominant sperm oocyte-activating factor. PLCZ1 cRNA expression or direct protein microinjection into mammalian oocytes
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c59de3137819f6926277742b4b78a64
https://pubmed.ncbi.nlm.nih.gov/35521907
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8
Impaired Binding to Junctophilin-2 and Nanostructural Alteration in CPVT Mutation
Autor: Yuriana Aguilar-Sanchez, Olivier Villejoubert, Feliciano Protasi, Liheng Yin, Camille Rabesahala de Meritens, Julio L. Álvarez, Pascale Gerbaud, Ernst Niggli, Romain Perrier, Pierre Joanne, Héctor H. Valdivia, F. Anthony Lai, Spyros Zissimopoulos, Riccardo Rizzetto, Esther Zorio, Elena Marques-Sule, Linwei Li, Yue Yi Wang, Yadan Zhang, Alexandra Zahradnikova Jr, Carmen R. Valdivia, Simona Boncompagni, Jean-Pierre Benitah, Valérie Nicolas, Ana Maria Gomez, Josefina Ramos-Franco, Philippe Mateo, Miguel Fernandez-Tenorio
Publikováno v: CIRCULATION RESEARCH
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Circulation Research
Circulation Research, American Heart Association, 2021, 129 (3), pp.e35-e52. ⟨10.1161/CIRCRESAHA.121.319094⟩
Circ Res
Rationale: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare disease, manifested by syncope or sudden death in children or young adults under stress conditions. Mutations in the Ca 2+ release channel/RyR2 (type 2 ryanodine recept
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65e2200fcbc412196d1bcdf3e2b9efab
https://fundanet.iislafe.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=14580
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9
Phospholipase C zeta profiles are indicative of optimal sperm parameters and fertilisation success in patients undergoing fertility treatment
Autor: Michail Nomikos, Reema B. Abu-Dawas, Nadya Al-Yacoub, Junaid Kashir, Serdar Coskun, Bhavesh V. Mistry, Abdullah M. Assiri, Saad Al-Hassan, F. Anthony Lai, Raed Abu-Dawud, Ahmed Ajlan, Lujain BuSaleh
Publikováno v: AndrologyREFERENCES. 8(5)
Oocyte activation is driven by intracellular calcium (Ca ) oscillations induced by sperm-specific PLCζ, abrogation of which causes oocyte activation deficiency in humans. Clinical PLCζ investigations have been limited to severe male infertility con
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc527e7e3f20fdce6eb3cd8d71a60d2
https://pubmed.ncbi.nlm.nih.gov/32298520
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10
Essential Role of Sperm-Specific PLC-Zeta in Egg Activation and Male Factor Infertility: An Update
Autor: Alaaeldin Saleh, Junaid Kashir, Angelos Thanassoulas, Bared Safieh-Garabedian, F. Anthony Lai, Michail Nomikos
Publikováno v: Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Sperm-specific phospholipase C zeta (PLCζ) is widely considered to be the physiological stimulus responsible for generating calcium (Ca2+) oscillations that induce egg activation and early embryonic development during mammalian fertilization. In the
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bca8da61481e6830142b1cf336a89b4b
http://europepmc.org/articles/PMC7000359
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