Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis

Autor: Nicholas Furnham, Mridul Nair, Theolis Costa Barbosa Bessa, Miguel Viveiros, Christophe Sola, Isabel Portugal, Robert M Warren, Moses Joloba, Jody Phelan, Maxine Caws, Saad Alghamdi, Zahra Hasan, Nora Mocillo, Rumina Hasan, Francesc Coll, Dang Minh Ha, Patricia Sheen, Edward C. Jones-López, Jaime Robledo, Tomoshige Matsumoto, Judith R. Glynn, Elizabeth M. Streicher, Nashwa Talaat Shesha, Arnab Pain, Adriana Alves, Louis Grandjean, Yaa Oppong, Mona Alsomali, Paul D. van Helden, Taane G. Clark, Shahjahan Ali, Anirvan Chatterjee, Martin L. Hibberd, Stephanie Portelli, Anabela Miranda, Kim Mallard, Abdallah O Ahmed, F. A. Sirgel, Carlos Penha, David Moore, Keertan Dheda, Abdallah M. Abdallah, Erivelton de Oliveira Sousa, Julian Parkhill, João Perdigão, Stefan Panaiotov, Zineb Rchiad, Grant A. Hill-Cawthorne, Amelia C. Crampin, Susana Campino, Ruth McNerney

Publikováno v: Nature Genetics
Nature Genetics, Nature Publishing Group, 2018, 50, pp.307-316. ⟨10.1038/s41588-017-0029-0⟩
Nature Genetics, 2018, 50, pp.307-316. ⟨10.1038/s41588-017-0029-0⟩

International audience; To characterize the genetic determinants of resistance to antituberculosis drugs, we performed a genome-wide association study (GWAS) of 6,465 $Mycobacterium\ tuberculosis$ clinical isolates from more than 30 countries. A GWAS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e582d147859ba8945b0591d02d3acf60
https://hdl.handle.net/20.500.12866/4080

Mycobacterium tuberculosis pncA Polymorphisms That Do Not Confer Pyrazinamide Resistance at a Breakpoint Concentration of 100 Micrograms per Milliliter in MGIT

Autor: Michael G. Whitfield, Alexandra Mercante, James E. Posey, Annelies Van Rie, Robin M. Warren, Melisa J. Willby, Kris Birkness, Paul D. van Helden, F. A. Sirgel, Elizabeth M. Streicher, Glenn P. Morlock, Kelsey Hughes, Samantha L. Sampson

Publikováno v: Journal of clinical microbiology. 53(11)

Sequencing of the Mycobacterium tuberculosis pncA gene allows for pyrazinamide susceptibility testing. We summarize data on pncA polymorphisms that do not confer resistance at a susceptibility breakpoint of 100 μg/ml pyrazinamide in MGIT within a co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c28743fd176861fc3d8b24a5afce109
https://pubmed.ncbi.nlm.nih.gov/26292310

Monitoring the ingestion of anti-tuberculosis drugs by simple non-invasive methods

Autor: P. J. Smith, F. A. Sirgel, Grant Langdon, Amour Venter, P.R. Donald, J. S. Maritz

Publikováno v: International Journal of Pharmaceutics. 307:182-187

This investigation retrospectively assessed inexpensive non-invasive qualitative methods to monitor the ingestion of anti-tuberculosis drugs isoniazid, rifampicin and rifapentine. Results showed that commercial test strips detected the isoniazid meta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae8b508557508aa37bf231c666ca28a2
https://doi.org/10.1016/j.ijpharm.2005.09.033

The Influence of Human N-Acetyltransferase Genotype on the Early Bactericidal Activity of Isoniazid

Autor: Amour Venter, Cedric J. Werely, H. I. Seifart, Peter R. Donald, D. P. Parkin, B. W. Van de Wal, P. D. van Helden, F. A. Sirgel, J. S. Maritz

Publikováno v: Clinical Infectious Diseases. 39:1425-1430

The elimination of isoniazid is subject to the influence of the N-acetyltransferase 2 (NAT2) genotype, and individuals may be homozygotic slow, heterozygotic fast, or homozygotic fast acetylators of isoniazid. The early bactericidal activity (EBA) of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::090ab540847a057389673b8c5ef5c0bb
https://doi.org/10.1086/424999

’n Oorsig van die bepaling van die vroeë bakterisidiese aktiwiteit van verskeie antituberkulosemiddels

Autor: P. R. Donald, F. A. Sirgel, A. Venter, P. B. Fourie, D. P. Parkin Parkin, H. I. Seifart, B. W. van de Wal, J. S. Maritz

Publikováno v: South African Journal of Science and Technology, Vol 22, Iss 2&3, Pp 79-88 (2003)
South African Journal of Science and Technology, Vol 22, Iss 2/3, Pp 79-88 (2003)

Die vroeë bakterisidiese aktiwiteit (VBA) van ’n antituberkulosemiddel is die daaglikse afname van M tuberculosis in log10 kolonievormende eenhede per ml sputum, tydens die eerste twee dae van behandeling met die middel. Dit weerspieël die vermo�

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::0278d09e7266c4fb99772c5bb35943fa
http://www.satnt.ac.za/index.php/satnt/article/view/215