The epidemiology of sepsis in Brazilian intensive care units (the Sepsis PREvalence Assessment Database, SPREAD): an observational study

Autor: Flavia R Machado, Alexandre Biasi Cavalcanti, Fernando Augusto Bozza, Elaine M Ferreira, Fernanda Sousa Angotti Carrara, Juliana Lubarino Sousa, Noemi Caixeta, Reinaldo Salomao, Derek C Angus, Luciano Cesar Pontes Azevedo, S R Zajac, M V Bley, A Scazufca, P Rosateli, T Reis, A Nogueira Junior, P A Nunes Neto, I L S Filho, H Lima, M Vieira, M Zanchet, I Ferreira, R Miguita, G M Petisco, G A Westphal, J R P Santos, V Damasceno, J T dos Santos, F Fernandes, EP Almeida, M Lemos, M F A Lima, R Camacho, A Ribeiro, M O G Douglas, G A Mattei, E A Junior, P Ferreira, H R M P Rabelo, S P S Pinto, L E Fontes, D Machado, M Guitzel, M Lucio, C N P Conceição, A Barros, D Salgado, V C Veiga, S S O Rojas, KM de Paula, R Hatum, L Fraenkel, W N Viana, A P G Santos, L Rabello, L Tanaka, M Uchoa, M D Moura, H Gneco, M F Buarque, K Monteiro, A P Nassar, E Koterba, M J Teixeira, A L E Falcão, V G S Pinto, J M M Junior, A L Gut, L M Stefano, M Damasceno, M V Lontra, C Cozzani, E B Sobrinho, S G Lage, L Kopel, N C M Youssef, L C Sanches, C P Amendola, C Kmohan, C B Silva, L Schifelbain, E Bellotto, P Viecili, L Azevedo, L Monteiro, S Vieira, A M Abrão, A P Moraes, H Insaurrale, M Gadelha, D Marisa, R N Diniz, E R Romano, S Luzzi, E Rezende, M C Filho, R H F C Martins, F B Carvalho, G C Moreira, J Paula, F Haag, FS Lucena, R S Machado, W O Filho, L O Cavalcante, H Carvalho Filho, G S Lima, J N Trombka, E C Machado, M P Bainy, C H Ramos, C Hoppe, G D Luckmeyer, C Vogas, M M Thompson, R K Sousa, R Fernandes, E Lourenço, G L Peixoto, A Mocelin, M M L Silva, J S A Neto, C Villela, S L Mendonça, S C Prado, R Goulart, J J L Duarte, H A O Junior, J N Andrade, L F Souza, L Fernandes, M L Neto, S S Fernandes, F Amâncio, J C Versiani, F Pitanga, M B Alcantara, C C Reiff, R Rosenblat, M S Nobrega, M L F S Nobrega, G Costa, N Assunção, E P Almeida, L Neder, R Almeida, J Fuck, R M Souza, A G Ribeiro, A A G Alves, S H C Carvalho, M Arbex, E C Oliveira, R S Melo, K Conde, N Q Abreu, C L T Melo, A A Carvalho, R Lannes, H Missaka, A H Furtado, A A Peixoto, I Maia, M P Pincelli, M P Yunes, A N Pessoa, S Figueiredo, F A Botoni, C T Cunha, F A Olson, R Franco, A F Bemfica, A D F Junior, E L A Ferreira, O Messeder, R Passos, J A Lira, C A Vilela, S M D Junior, C S Ferreira, O P J A Muller, R Perreira dos Santos, P Rubini, D Monteiro, L E Rodrigues, G F Ruivo, M C Gomes, E Egito, M G Assef, M A M Lima, A F Borges, S Jezler, C Mendes, P C Gottardo, R Lima, C M F Filho, V P Campagnucci, I Solino, A P Lorca, G M Rodrigues, K B Gerent, O Barbosa, G T Henriques Filho, E Troncoso, A Ventura, M A Silva, J G Houly, J P M Pimentel, R A Ramos, F Gianini, B Casemiro, E M Pinto, G A Silva, M Sebold, E Vieira, R Ferreira, L A Gomes, W J Lovato, W Dantas, L Ishy, J Moreira, I Gagliardi, L O Goes, L S Vendrame, H P Guimarães, A Gois, F R Machado, M Rodrigues, P C B Vieira, W Bittencourt, E Melnick, M Schneider, L Rezegue, N J M Nogueira, E P Godinho, B F Mazza, L E Paciencia, S Ferraz, C R A Imamura, J Tavares, J C Santos, E Vale, J Mugait Filho, L A Tannous, P G D João, C T I Geral, A P Matera, M Matsui, E Eberhart Neto, B V Pinheiro, E V Carvalho, H Matos, M Lippi, A L Campos, D C Albuquerque, D Castiglioni, G S Silva, S Cunha, E Novello, M E B Silva, C Grion, J Festti, C R A Souza, G C Mecatti, E B Junqueira, R S Dutra, G B Mirachi, D A Mendes, E M F Moura, I F Silva, M G P Mota, T Carneiro, A Celso, A Réa-Neto, M C Oliveira, A Japiassú, P P Castro, H J M Costa, A V Rolim, D Rocha, C Righy, V Santos, B Fernandino, A L Pereira, V L D Rego, L A Melo, L Guilherme, H Chagas Ferro, F J L Silva, H V C J Carrasco, S El-Fakouri, J Alvarez, D de Castro, P M Shiavetto, S R Gallate, E Thomé Filho, S G Veneziano, P Antoniazzi, W H Filho, P Sadala, C Balbino, G Moreno, M S F Dias, R P Lopez, M L Rodrigues, J Terceiro, M F Serpa, L Santos, M M Lippi

Publikováno v: The Lancet Infectious Diseases. 17:1180-1189

Summary Background The sepsis burden on acute care services in middle-income countries is a cause for concern. We estimated incidence, prevalence, and mortality of sepsis in adult Brazilian intensive care units (ICUs) and association of ICU organisat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3cf58c4a9750797ac428bdd36e403d77
https://doi.org/10.1016/s1473-3099(17)30322-5

Process biology: integrated genomics and bioinformatics tools for improved target assessment

Autor: Juergen Hammer, John F. Reidhaar-Olson, Michael Braxenthaler

Publikováno v: TARGETS. 1:189-195

The availability of the human genome sequence has greatly increased the number of potential drug targets in recent years. As a result, the way targets are assessed has become crucial to the success of the drug discovery process. Unfortunately, the tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::67efb8d695df2f8d8201b29235e48d1a
https://doi.org/10.1016/s1477-3627(02)02263-8

Active variants of human parathyroid hormone (1–34) with multiple amino acid substitutions

Autor: Robyn M. Davis, John F. Reidhaar-Olson, Harold E Selick, Janet A De Souza-Hart

Publikováno v: Molecular and Cellular Endocrinology. 160:135-147

We used site-directed mutagenesis to construct 55 single-site variants of rhPTH, a recombinantly-expressed form of human parathyroid hormone (1–34) containing three amino acid changes compared to the natural sequence (ML8, ML18 and FY34). We identi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4cd6d7a3a1ac0003260cbc335724d88f
https://doi.org/10.1016/s0303-7207(99)00211-7

Therapeutic Applications of RNAi

Autor: John F. Reidhaar-Olson, Cristina M. Rondinone

Publikováno v: Methods in Molecular Biology™ ISBN: 9781603272940
Therapeutic Applications of RNAi

The vision of using a single therapeutic agent with sufficient generality to allow application to a wide variety of diseases, yet specific enough to permit intervention at single molecular stages of the pathology, is rapidly becoming a reality throug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4017a53e467f63d816b67f23686864e3
https://doi.org/10.1007/978-1-60327-295-7

Deciphering the Message in Protein Sequences: Tolerance to Amino Acid Substitutions

Autor: John F. Reidhaar-Olson, Robert T. Sauer, Wendell A. Lim, James U. Bowie

Publikováno v: Science. 247:1306-1310

An amino acid sequence encodes a message that determines the shape and function of a protein. This message is highly degenerate in that many different sequences can code for proteins with essentially the same structure and activity. Comparison of dif

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::374059ea65ef0739a2b29ccd5ae5701f
https://doi.org/10.1126/science.2315699