Abstract PS11-33: A first-in-human Phase 1/1b multicenter, open-label dose escalation study to assess safety and tolerability of PMD-026, a first-in-class oral RSK inhibitor, in metastatic breast cancer patients

Autor: Lida A. Mina, F. Andrew Dorr, My-my Huynh, Gerrit Los, Judy S. Wang, Pavani Chalasani, Aarthi Jayanthan, Murali Beeram, Amita Patnaik, Sandra E. Dunn, Mary Rose Pambid

Publikováno v: Cancer Research. 81:PS11-33

Background: Metastatic breast cancer (mBC) remains an aggressive disease with limited durable treatment options; the worst prognosis among the breast cancer subtypes is typically seen in metastatic triple-negative breast cancer (mTNBC). Given that un

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::16343f734837c6b97dcccb09714c31c1
https://doi.org/10.1158/1538-7445.sabcs20-ps11-33

Efficacy and toxicity of the antisense oligonucleotide aprinocarsen directed against protein kinase C-α delivered as a 21-day continuous intravenous infusion in patients with recurrent high-grade astrocytomas

Autor: Jon Holmlund, Jeffrey G. Supko, Regina Priet, F. Andrew Dorr, John S. Grundy, Stuart A. Grossman, Kathryn A. Carson, Jane B. Alavi

Publikováno v: Neuro-Oncology. 7:32-40

Protein kinase C alpha (PKC-alpha) is a cytoplasmic serine threonine kinase involved in regulating cell differentiation and proliferation. Aprinocarsen is an antisense oligonucleotide against PKC-alpha that reduces PKC-alphain human cell lines and in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80e13ef1b1f8b9433a53e985b035224e
https://doi.org/10.1215/s1152851703000353

Virological Effects of Isis 14803, An Antisense Oligonucleotide Inhibitor of Hepatitis C Virus (HCV) Internal Ribosome Entry Site (IRES), on HCV Ires in Chronic Hepatitis C Patients and Examination of the Potential Role of Primary and Secondary HCV Resistance in the Outcome of Treatment

Autor: T. Jesse Kwoh, Muriel Soler, John G. McHutchison, Jean-Michel Pawlotsky, F. Andrew Dorr

Publikováno v: Antiviral Therapy. 9:953-968

Antisense oligonucleotides represent a promising class of antiviral agents. ISIS 14803 is a 20-unit phosphorothioate oligodeoxynucleotide that inhibited hepatitis C virus (HCV) replication and protein expression in cell culture and mouse models. A Ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0b254d700156d6d0d0a505c52f4f27c2
https://doi.org/10.1177/135965350400900612

Association of c-Raf expression with survival and its targeting with antisense oligonucleotides in ovarian cancer

Autor: A.A. Ritchie, John F. Smyth, Brett P. Monia, Peter Mullen, Simon P. Langdon, Fiona McPhillips, F A Dorr

Publikováno v: British Journal of Cancer
2001, ' Association of c-Raf expression with survival and its targeting with antisense oligonucleotides in ovarian cancer. ', British Journal of Cancer, vol. 85, pp. 1753-1758 . https://doi.org/10.1054/bjoc.2001.2139

c-Raf is an essential component of the extracellular related kinase (ERK) signal transduction pathway. Immunohistochemical staining indicated that c-Raf was present in 49/53 ovarian adenocarcinomas investigated and high c-Raf expression correlated si

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f1d7f9459b30aecf2b379594770975
https://doi.org/10.1054/bjoc.2001.2139

Phase II study of single-agent gemcitabine in previously untreated patients with metastatic urothelial cancer

Autor: Derek Raghavan, F A Dorr, Walter M. Stadler, Bruce J. Roth, Timothy M. Kuzel

Publikováno v: Journal of Clinical Oncology. 15:3394-3398

PURPOSE To determine the activity of single-agent gemcitabine in previously untreated patients with metastatic transitional cell cancer. METHODS Forty patients with measurable disease and a Karnofsky performance status > or = 60% were enrolled at fiv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7d8893b16ad6eebff6fa53302fdff89
https://doi.org/10.1200/jco.1997.15.11.3394