Zobrazeno 1 - 2
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pro vyhledávání: '"F A, Alvarez Núñez"'
Publikováno v:
International Journal of Pharmaceutics. 151:193-199
A novel method to determine the p K a of surface active compounds is presented. Since the ionized and unionized forms of amphiphiles have distinct surface and foaming properties, foamability as a function of pH can be used to obtain an approximate p
Autor:
F A, Alvarez Núñez, S H, Yalkowsky
Publikováno v:
PDA journal of pharmaceutical science and technology. 52(1)
Several attempts to increase diazepam solubility are in the literature. This study discusses these different solubilization approaches. Specific reference is given to the rationale in the application of pH control, cosolvency, surfactants, and cyclod