Synthesis, oligonucleotide incorporation and fluorescence properties in DNA of a bicyclic thymine analogue

Autor: Lawson, CP, Füchtbauer, AF, Wranne, MS, Giraud, T, Floyd, T, Dumat, B, Andersen, NK, El-Sagheer, A, Brown, T, Gradén, H, Wilhelmsson, LM, Grøtli, M

Publikováno v: Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)

Fluorescent base analogues (FBAs) have emerged as a powerful class of molecular reporters of location and environment for nucleic acids. In our overall mission to develop bright and useful FBAs for all natural nucleobases, herein we describe the synt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a875a0ac6fd26e35f1b3e21ecdc2b3b5
https://doaj.org/article/91467726e61f4f76abb1785ce4f6f727

Sulfone-based human liver pyruvate kinase inhibitors - Design, synthesis and in vitro bioactivity.

Autor: Matić J; Department of Chemistry and Molecular Biology, University of Gothenburg, SE-412 96, Gothenburg, Sweden; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden., Akladios F; Department of Chemistry and Molecular Biology, University of Gothenburg, SE-412 96, Gothenburg, Sweden; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden., Battisti UM; Department of Chemistry and Molecular Biology, University of Gothenburg, SE-412 96, Gothenburg, Sweden; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden., Håversen L; Department of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital, SE-413 45, Gothenburg, Sweden., Nain-Perez A; Department of Chemistry and Molecular Biology, University of Gothenburg, SE-412 96, Gothenburg, Sweden; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden., Füchtbauer AF; Department of Chemistry and Molecular Biology, University of Gothenburg, SE-412 96, Gothenburg, Sweden; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden., Kim W; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden., Monjas L; Department of Chemistry and Molecular Biology, University of Gothenburg, SE-412 96, Gothenburg, Sweden; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden., Rivero AR; Department of Chemistry and Molecular Biology, University of Gothenburg, SE-412 96, Gothenburg, Sweden; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden., Borén J; Department of Molecular and Clinical Medicine, University of Gothenburg and Sahlgrenska University Hospital, SE-413 45, Gothenburg, Sweden., Mardinoglu A; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden; Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, SE1 9RT, UK., Uhlen M; Science for Life Laboratory, KTH - Royal Institute of Technology, Stockholm, Sweden., Grøtli M; Department of Chemistry and Molecular Biology, University of Gothenburg, SE-412 96, Gothenburg, Sweden. Electronic address: grotli@gu.se.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2024 Apr 05; Vol. 269, pp. 116306. Date of Electronic Publication: 2024 Mar 05.

Flexibility and Preorganization of Fluorescent Nucleobase-Pyrene Conjugates Control DNA and RNA Recognition.

Autor: Ban Ž; Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička Cesta 54, 10000 Zagreb, Croatia., Matić J; Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička Cesta 54, 10000 Zagreb, Croatia., Žinić B; Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička Cesta 54, 10000 Zagreb, Croatia., Füchtbauer AF; Department of Chemistry and Chemical Engineering/Chemistry and Biochemistry, Chalmers University of Technology, S-41296 Gothenburg, Sweden., Wilhelmsson LM; Department of Chemistry and Chemical Engineering/Chemistry and Biochemistry, Chalmers University of Technology, S-41296 Gothenburg, Sweden., Piantanida I; Division of Organic Chemistry and Biochemistry, Ruđer Bošković Institute, Bijenička Cesta 54, 10000 Zagreb, Croatia.

Publikováno v: Molecules (Basel, Switzerland) [Molecules] 2020 May 07; Vol. 25 (9). Date of Electronic Publication: 2020 May 07.

Interbase FRET in RNA: from A to Z.

Autor: Füchtbauer AF; Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg SE-412 96, Sweden., Wranne MS; Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg SE-412 96, Sweden., Bood M; Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg SE-412 96, Sweden.; Medicinal Chemistry, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Weis E; Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg SE-412 96, Sweden.; Medicinal Chemistry, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Pfeiffer P; Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg SE-412 96, Sweden., Nilsson JR; Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg SE-412 96, Sweden., Dahlén A; Medicinal Chemistry, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden., Grøtli M; Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg SE-412 96, Sweden., Wilhelmsson LM; Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg SE-412 96, Sweden.

Publikováno v: Nucleic acids research [Nucleic Acids Res] 2019 Nov 04; Vol. 47 (19), pp. 9990-9997.

Pentacyclic adenine: a versatile and exceptionally bright fluorescent DNA base analogue.

Autor: Bood M; Department of Chemistry and Molecular Biology , University of Gothenburg , SE-412 96 Gothenburg , Sweden . Email: grotli@chem.gu.se., Füchtbauer AF; Department of Chemistry and Chemical Engineering, Chemistry and Biochemistry , Chalmers University of Technology , SE-412 96 Gothenburg , Sweden . Email: marcus.wilhelmsson@chalmers.se., Wranne MS; Department of Chemistry and Chemical Engineering, Chemistry and Biochemistry , Chalmers University of Technology , SE-412 96 Gothenburg , Sweden . Email: marcus.wilhelmsson@chalmers.se., Ro JJ; Department of Chemistry , Division of Advanced Materials Science , Pohang University of Science and Technology (POSTECH) , Pohang 37673 , South Korea., Sarangamath S; Department of Chemistry and Chemical Engineering, Chemistry and Biochemistry , Chalmers University of Technology , SE-412 96 Gothenburg , Sweden . Email: marcus.wilhelmsson@chalmers.se., El-Sagheer AH; Chemistry Branch , Faculty of Petroleum and Mining Engineering , Suez University , Suez 43721 , Egypt., Rupert DLM; Division of Biological Physics , Department of Physics , Chalmers University of Technology , SE-412 96 Gothenburg , Sweden., Fisher RS; School of Chemistry , University of Edinburgh , The King's Buildings , Edinburgh EH9 3JJ , UK., Magennis SW; WestCHEM , School of Chemistry , University of Glasgow , Glasgow , G12 8QQ , UK., Jones AC; School of Chemistry , University of Edinburgh , The King's Buildings , Edinburgh EH9 3JJ , UK., Höök F; Division of Biological Physics , Department of Physics , Chalmers University of Technology , SE-412 96 Gothenburg , Sweden., Brown T; Department of Chemistry , Chemistry Research Laboratory , University of Oxford , Oxford , OX1 3TA , UK., Kim BH; Department of Chemistry , Division of Advanced Materials Science , Pohang University of Science and Technology (POSTECH) , Pohang 37673 , South Korea., Dahlén A; AstraZeneca R&D , Innovative Medicines , Cardiovascular & Metabolic Diseases (CVMD) , Pepparedsleden 1, SE-431 83 Mölndal , Gothenburg , Sweden., Wilhelmsson LM; Department of Chemistry and Chemical Engineering, Chemistry and Biochemistry , Chalmers University of Technology , SE-412 96 Gothenburg , Sweden . Email: marcus.wilhelmsson@chalmers.se., Grøtli M; Department of Chemistry and Molecular Biology , University of Gothenburg , SE-412 96 Gothenburg , Sweden . Email: grotli@chem.gu.se.

Publikováno v: Chemical science [Chem Sci] 2018 Mar 01; Vol. 9 (14), pp. 3494-3502. Date of Electronic Publication: 2018 Mar 01 (Print Publication: 2018).