Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Félix, Calderón"'
Autor:
Nathaniel G. Jones, Vincent Geoghegan, Gareth Moore, Juliana B. T. Carnielli, Katherine Newling, Félix Calderón, Raquel Gabarró, Julio Martín, Rab K. Prinjha, Inmaculada Rioja, Anthony J. Wilkinson, Jeremy C. Mottram
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Leishmania use large (5–10 kb) transcriptional start regions, where the chromatin is highly enriched for acetylated histones, to drive the expression of polycistronic gene arrays. Here the authors show bromodomain-containing protein BDF5 is enriche
Externí odkaz:
https://doaj.org/article/1db1b17d7f85497d9117d4a2f66ff272
Autor:
Maria G. Nava, Félix Calderón, Elena Fernández, Lluis Ballell, Paul Bamborough, Sumiti Vinayak
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 1 (2023)
ABSTRACT The protozoan parasite Cryptosporidium is a leading cause of diarrheal disease (cryptosporidiosis) and death in young children. Cryptosporidiosis can be life-threatening in individuals with weak immunity such as HIV/AIDS patients and organ t
Externí odkaz:
https://doaj.org/article/257581ab66cc48f8a0517186a117a628
Autor:
Michael J. Delves, Celia Miguel-Blanco, Holly Matthews, Irene Molina, Andrea Ruecker, Sabrina Yahiya, Ursula Straschil, Matthew Abraham, María Luisa León, Oliver J. Fischer, Ainoa Rueda-Zubiaurre, Jochen R. Brandt, Álvaro Cortés, Anna Barnard, Matthew J. Fuchter, Félix Calderón, Elizabeth A. Winzeler, Robert E. Sinden, Esperanza Herreros, Francisco J. Gamo, Jake Baum
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Sexual forms of malaria parasites are responsible for transmission to the mosquito. Anti-malarial drug resistance remains a serious problem and requires advent of new drug therapies. Here, the authors present a high-throughput screen of potential ant
Externí odkaz:
https://doaj.org/article/920f37303ca446e0a2ceaa2cbd0d76bf
Autor:
Courtney C. Aldrich, Félix Calderón, Stuart J. Conway, Chuan He, Jacob M. Hooker, Donna M. Huryn, Craig W. Lindsley, Dennis C. Liotta, Christa E. Müller
Publikováno v:
ACS Chemical Neuroscience. 13:2668-2673
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71f0009e408e7311adde6fc28739ada5
https://doi.org/10.1021/acschemneuro.2c00501
https://doi.org/10.1021/acschemneuro.2c00501
Autor:
Bryan K.S. Yeung, Félix Calderón
Publikováno v:
Burger's Medicinal Chemistry and Drug Discovery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7b8a713cd403c72b0f9065fdf2d1a2a
https://doi.org/10.1002/0471266949.bmc234.pub2
https://doi.org/10.1002/0471266949.bmc234.pub2
Autor:
Nathaniel G. Jones, Vincent Geoghegan, Gareth Moore, Juliana B. T. Carnielli, Katherine Newling, Félix Calderón, Raquel Gabarró, Julio Martín, Rab K. Prinjha, Inmaculada Rioja, Anthony J. Wilkinson, Jeremy C. Mottram
Publikováno v:
Nature communications. 13(1)
Leishmania are unicellular parasites that cause human and animal diseases. Like other kinetoplastids, they possess large transcriptional start regions (TSRs) which are defined by histone variants and histone lysine acetylation. Cellular interpretatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d972befea4a23cca61644253705505f
https://pubmed.ncbi.nlm.nih.gov/35831302
https://pubmed.ncbi.nlm.nih.gov/35831302
Autor:
Daniel F. Simola, Paul Bamborough, Chun-wa Chung, Julio Martin, Robert B. Kirkpatrick, Inmaculada Rioja, Cynthia Tallant, Francisco-Javier Gamo, Félix Calderón, Raquel Gabarró, Chris Larminie, Rab K. Prinjha
Publikováno v:
ACS infectious diseases. 7(11)
This Perspective discusses the published data and recent developments in the research area of bromodomains in parasitic protozoa. Further work is needed to evaluate the tractability of this target class in the context of infectious diseases and launc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deb091993c155565ea4f163d922293fd
https://pubmed.ncbi.nlm.nih.gov/34612618
https://pubmed.ncbi.nlm.nih.gov/34612618
Autor:
Geoghegan, Moore G, Jeffrey N. Martin, Félix Calderón, Jeremy C. Mottram, Raquel Gabarró, Carnielli Jbt, Rab K. Prinjha, Nathaniel G. Jones, Anthony J. Wilkinson, Katherine Newling, Inmaculada Rioja
Leishmania are unicellular parasites that cause human and animal disease. Alongside other organisms in kinetoplastida, they have evolved an unusual genome architecture that requires all RNA polymerase II transcribed genes to be expressed constitutive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d35767b0dacc9c3aaeca9092d45a1e6a
https://doi.org/10.1101/2021.09.29.462384
https://doi.org/10.1101/2021.09.29.462384
Publikováno v:
The Journal of experimental medicine. 218(9)
A unique experiment in bringing academic and industrial scientists together to tackle endemic infectious diseases has proved a success. The Tres Cantos Open Lab Foundation, guided and advised by independent experts, funds extended stays of academics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30c1dd3f251476e14b12ae729a74d01e
https://pubmed.ncbi.nlm.nih.gov/34410327
https://pubmed.ncbi.nlm.nih.gov/34410327
Autor:
Sara Palomo, Anke Harupa, Raquel Fernandez-Menendez, Félix Calderón, Laura Fernández de las Heras, Bart L. Staker, Chun-wa Chung, Alexandra Reers, Manuela Berlanga, Gonzalo Colmenarejo, Alexis Kaushansky, Esperanza Herreros-Aviles, Sally Lyons-Abbott, Iván Caballero Hernandez, David Charter, Peter J. Myler, Elena Fernández Álvaro, Beatriz Rodriguez
Publikováno v:
Journal of Medicinal Chemistry. 63:591-600
New drugs that target Plasmodium species, the causative agents of malaria, are needed. The enzyme N-myristoyltransferase (NMT) is an essential protein, which catalyzes the myristoylation of protein substrates, often to mediate membrane targeting. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29fb711eda5a7b27b4a4be7a024f0179
https://doi.org/10.1021/acs.jmedchem.9b01343
https://doi.org/10.1021/acs.jmedchem.9b01343