P2X7 receptor induces mitochondrial failure in monocytes and compromises NLRP3 inflammasome activation during sepsis

Autor: Juan José Martínez-García, Helios Martínez-Banaclocha, Diego Angosto-Bazarra, Carlos de Torre-Minguela, Alberto Baroja-Mazo, Cristina Alarcón-Vila, Laura Martínez-Alarcón, Joaquín Amores-Iniesta, Fátima Martín-Sánchez, Giovanni A. Ercole, Carlos M. Martínez, Ada González-Lisorge, José Fernández-Pacheco, Piedad Martínez-Gil, Sahil Adriouch, Friedrich Koch-Nolte, Juan Luján, Francisco Acosta-Villegas, Pascual Parrilla, Carlos García-Palenciano, Pablo Pelegrin

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Systemic sepsis is a potentially life-threatening illness and immunocompromised individuals are especially vulnerable. Here, using a cohort of patients with intra-abdominal origin sepsis, the authors show an important role for the NLRP3 inflammasome

Externí odkaz: https://doaj.org/article/1ae90a92ab1d45b3b618703a201c9c3b

Isolation of Particles of Recombinant ASC and NLRP3

Autor: Fátima Martín-Sánchez, Ana Gómez, Pablo Pelegrín

Publikováno v: Bio-Protocol, Vol 5, Iss 10 (2015)

NLRP3 inflammasome is a multiprotein complex responsible for the activation of inflammatory caspase-1, resulting in processing and release of pro-inflammatory cytoquines IL-1β and IL-18 (Schroder and Tschopp, 2010). This inflammasome is composed of

Externí odkaz: https://doaj.org/article/5a1bd27eab494ba092e6d669f8d8b766

NLRP3 activation in response to disrupted endocytic traffic

Autor: David Brough, Rose Wellens, Jack Peter Green, Fátima Martín-Sánchez, Bali Lee, Martin Lowe, Hayley M. Bennett, Paula I. Seoane, Daniel Williams, Gloria Lopez-Castejon, Antony Adamson, Christopher Hoyle

Inflammation driven by the NLRP3 inflammasome is coordinated through multiple signaling pathways and with a poorly defined regulation by sub-cellular organelles. Here, we tested the hypothesis that NLRP3 senses disrupted endosome trafficking to trigg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::846b12033a4b6b8e76892bee79973ee9
https://doi.org/10.1101/2021.09.15.460426

Internalization of the Membrane Attack Complex Triggers NLRP3 Inflammasome Activation and IL-1β Secretion in Human Macrophages

Autor: Gloria Lopez-Castejon, Jonathan D. Worboys, Ashley R. Ambrose, Fátima Martín-Sánchez, Eva-Maria Nichols, Daniel M. Davis, Anna Gritsenko, Gillian Margaret Tannahill, Ines Diaz-del-Olmo

Publikováno v: Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Diaz-del-Olmo, I, Worboys, J, Martin-Sanchez, F, Gritsenko, A, Ambrose, A R, Tannahill, G M, Nichols, E-M, Lopez-Castejon, G & Davis, D M 2021, ' Internalization of the Membrane Attack Complex Triggers NLRP3 Inflammasome Activation and IL-1β Secretion in Human Macrophages ', Frontiers in Immunology, vol. 12, 720655 . https://doi.org/10.3389/fimmu.2021.720655

Interleukin 1β (IL-1β) plays a major role in inflammation and is secreted by immune cells, such as macrophages, upon recognition of danger signals. Its secretion is regulated by the inflammasome, the assembly of which results in caspase 1 activatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e852a101875e12e51025826aa1339226
https://www.frontiersin.org/articles/10.3389/fimmu.2021.720655/full

Priming is dispensable for NLRP3 inflammasome activation in human monocytes

Autor: Anna Gritsenko, Shi Yu, Daniel M. Davis, I. Diaz del Olmo, Gloria Lopez-Castejon, David Brough, Fátima Martín-Sánchez, Eva-Maria Nichols

Interleukin (IL)-1 family of cytokines modulate immune responses during infection and inflammation. IL-18 and IL-1β are members of the IL-1 family, which contribute to inflammatory conditions such as rheumatoid arthritis and Alzheimer’s disease. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b9cf1d7b9943afb799e443c75436992
https://doi.org/10.1101/2020.01.30.925248