Zobrazeno 1 - 10
of 67
pro vyhledávání: '"Fátima Al‐Shahrour"'
Autor:
Bruna Calsina, Elena Piñeiro-Yáñez, Ángel M. Martínez-Montes, Eduardo Caleiras, Ángel Fernández-Sanromán, María Monteagudo, Rafael Torres-Pérez, Coral Fustero-Torre, Marta Pulgarín-Alfaro, Eduardo Gil, Rocío Letón, Scherezade Jiménez, Santiago García-Martín, Maria Carmen Martin, Juan María Roldán-Romero, Javier Lanillos, Sara Mellid, María Santos, Alberto Díaz-Talavera, Ángeles Rubio, Patricia González, Barbara Hernando, Nicole Bechmann, Margo Dona, María Calatayud, Sonsoles Guadalix, Cristina Álvarez-Escolá, Rita M. Regojo, Javier Aller, Maria Isabel Del Olmo-Garcia, Adrià López-Fernández, Stephanie M. J. Fliedner, Elena Rapizzi, Martin Fassnacht, Felix Beuschlein, Marcus Quinkler, Rodrigo A. Toledo, Massimo Mannelli, Henri J. Timmers, Graeme Eisenhofer, Sandra Rodríguez-Perales, Orlando Domínguez, Geoffrey Macintyre, Maria Currás-Freixes, Cristina Rodríguez-Antona, Alberto Cascón, Luis J. Leandro-García, Cristina Montero-Conde, Giovanna Roncador, Juan Fernando García-García, Karel Pacak, Fátima Al-Shahrour, Mercedes Robledo
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
The molecular mechanisms underlying metastasis in pheochromocytoma/paraganglioma (mPPGL) remain to be explored. Here, the authors perform genomic and immunogenomic profiling of mPPGL tumors and suggest potential biomarkers for risk of metastasis and
Externí odkaz:
https://doaj.org/article/69b48437dc7349d2ae46afb0ace70885
Autor:
Eduardo Ruiz-López, Ivana Jovčevska, Ruth González-Gómez, Héctor Tejero, Fátima Al-Shahrour, Serge Muyldermans, Alberto J. Schuhmacher
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The cancer “omics” reveal many clinically relevant alterations that are transforming the molecular characterization of glioblastomas. However, many of these findings are not yet translated into clinical practice due, in part, to the lack
Externí odkaz:
https://doaj.org/article/0affb9e0bbb04e53b8f93d6798240ad8
Autor:
María José Jiménez‐Santos, Santiago García‐Martín, Coral Fustero‐Torre, Tomás Di Domenico, Gonzalo Gómez‐López, Fátima Al‐Shahrour
Publikováno v:
Molecular Oncology, Vol 16, Iss 21, Pp 3881-3908 (2022)
Tumour heterogeneity is one of the main characteristics of cancer and can be categorised into inter‐ or intratumour heterogeneity. This heterogeneity has been revealed as one of the key causes of treatment failure and relapse. Precision oncology is
Externí odkaz:
https://doaj.org/article/9ec3d70fca6746f6b5ef2e34e4281a06
Autor:
Alicia Sánchez-Sanz, Santiago García-Martín, Julia Sabín-Muñoz, Irene Moreno-Torres, Víctor Elvira, Fátima Al-Shahrour, Aranzazu García-Grande, Elvira Ramil, Ofir Rodríguez-De la Fuente, Beatriz Brea-Álvarez, Ruth García-Hernández, Antonio García-Merino, Antonio José Sánchez-López
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Background and objectiveDimethyl fumarate (DMF) is an immunomodulatory drug approved for the therapy of multiple sclerosis (MS). The identification of response biomarkers to DMF is a necessity in the clinical practice. With this aim, we studied the i
Externí odkaz:
https://doaj.org/article/1e48099cbabe47af932b66bcc498ce5e
Autor:
Laura Sanchez‐Burgos, Belén Navarro‐González, Santiago García‐Martín, Oleksandra Sirozh, Jorge Mota‐Pino, Elena Fueyo‐Marcos, Héctor Tejero, Marta Elena Antón, Matilde Murga, Fátima Al‐Shahrour, Oscar Fernandez‐Capetillo
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 9, Pp 1-18 (2022)
Abstract FBXW7 is one of the most frequently mutated tumor suppressors, deficiency of which has been associated with resistance to some anticancer therapies. Through bioinformatics and genome‐wide CRISPR screens, we here reveal that FBXW7 deficienc
Externí odkaz:
https://doaj.org/article/256932fb4a3044ed836a66ac7c89974f
Autor:
Marina Salmón, Ruth Álvarez-Díaz, Coral Fustero-Torre, Oksana Brehey, Carmen G. Lechuga, Manuel Sanclemente, Fernando Fernández-García, Alejandra López-García, María Carmen Martín-Guijarro, Sandra Rodríguez-Perales, Emily Bousquet-Mur, Lucía Morales-Cacho, Francisca Mulero, Fátima Al-Shahrour, Lola Martínez, Orlando Domínguez, Eduardo Caleiras, Sagrario Ortega, Carmen Guerra, Monica Musteanu, Matthias Drosten, Mariano Barbacid
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 7 (2023)
KRASG12C inhibitors have revolutionized the clinical management of patients with KRASG12C-mutant lung adenocarcinoma. However, patient exposure to these inhibitors leads to the rapid onset of resistance. In this study, we have used genetically engine
Externí odkaz:
https://doaj.org/article/a51ce49b33904d3e80b5fe3757365959
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract The ongoing COVID-19 pandemic is one of the biggest health challenges of recent decades. Among the causes of mortality triggered by SARS-CoV-2 infection, the development of an inflammatory “cytokine storm” (CS) plays a determinant role.
Externí odkaz:
https://doaj.org/article/ce36e435925c419e8e5abf9ccf52422a
Autor:
Coral Fustero-Torre, María José Jiménez-Santos, Santiago García-Martín, Carlos Carretero-Puche, Luis García-Jimeno, Vadym Ivanchuk, Tomás Di Domenico, Gonzalo Gómez-López, Fátima Al-Shahrour
Publikováno v:
Genome Medicine, Vol 13, Iss 1, Pp 1-15 (2021)
Abstract We present Beyondcell, a computational methodology for identifying tumour cell subpopulations with distinct drug responses in single-cell RNA-seq data and proposing cancer-specific treatments. Our method calculates an enrichment score in a c
Externí odkaz:
https://doaj.org/article/a8f0969e9dc24d2989a07cfd172f5edf
Autor:
Jordi Martorell-Marugán, Raúl López-Domínguez, Adrián García-Moreno, Daniel Toro-Domínguez, Juan Antonio Villatoro-García, Guillermo Barturen, Adoración Martín-Gómez, Kevin Troule, Gonzalo Gómez-López, Fátima Al-Shahrour, Víctor González-Rumayor, María Peña-Chilet, Joaquín Dopazo, Julio Sáez-Rodríguez, Marta E. Alarcón-Riquelme, Pedro Carmona-Sáez
Publikováno v:
BMC Bioinformatics, Vol 22, Iss 1, Pp 1-14 (2021)
Abstract Background Autoimmune diseases are heterogeneous pathologies with difficult diagnosis and few therapeutic options. In the last decade, several omics studies have provided significant insights into the molecular mechanisms of these diseases.
Externí odkaz:
https://doaj.org/article/9d042e0eda33436597b7e2f20477a1c9
Autor:
Jon Sánchez-Valle, Héctor Tejero, José María Fernández, David Juan, Beatriz Urda-García, Salvador Capella-Gutiérrez, Fátima Al-Shahrour, Rafael Tabarés-Seisdedos, Anaïs Baudot, Vera Pancaldi, Alfonso Valencia
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Disease comorbidity is attracting increasing attention, but the involvement of molecular factors in forecasting risk of a disease in the presence of other diseases is poorly understood. Here the authors build a disease interaction network based on ge
Externí odkaz:
https://doaj.org/article/b8e750206f194b8fa013e289241caa12