Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Fátima, Cairrão"'
Autor:
Fátima Cairrão, Cristiana C. Santos, Adrien Le Thomas, Scot Marsters, Avi Ashkenazi, Pedro M. Domingos
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
In Drosophila, ER-targeted mRNAs are degraded by Ire1-dependent pathway. Here the authors report that the fly mRNA binding protein Pumilio is phosphorylated by Ire1 and binds to Xbp1 mRNA, protecting it from the non-canonical endoribonuclease activit
Externí odkaz:
https://doaj.org/article/4136424ab196470b833fcd5fa037db28
Publikováno v:
Nature communications. 13(1)
SUMMARYThe unfolded protein response (UPR) maintains homeostasis of the endoplasmic reticulum(ER). Residing in the ER membrane, the UPR mediator Ire1 deploys its cytoplasmic kinase-endoribonuclease domain to activate the key UPR transcription factor
Autor:
David Ron, Pedro Domingos, Fátima Cairrão, Ana Varela Coelho, Dina S. Coelho, Xiaomei Zeng, Elisabete Pires, Hyung Don Ryoo
Publikováno v:
Cell Reports, Vol 5, Iss 3, Pp 791-801 (2013)
The Unfolded Protein Response (UPR) is composed by homeostatic signaling pathways that are activated by excessive protein misfolding in the endoplasmic reticulum (ER). Ire1 signaling is an important mediator of the UPR, leading to the activation of t
Autor:
Fátima Cairrão, Cecília M. Arraiano
Publikováno v:
Biochemical and Biophysical Research Communications. 343:731-737
RNase R is an important exoribonuclease involved in the maturation and degradation of RNA. RNase R is co-transcribed with other genes in the same operon. In this report, we show that under physiological conditions maturation of these co-transcripts a
Publikováno v:
Molecular Microbiology. 60:219-228
In nature, bacteria remain mostly in the stationary phase of the life cycle. Although mRNA is a major determinant of gene expression, little is known about mRNA decay in the stationary phase. The results presented herein demonstrate that RNase R is i
Publikováno v:
Developmental Dynamics. 232:733-737
The major 3'-5' pathway of RNA degradation in eukaryotic cells involves the exosome, which is a multi-protein complex of exoribonucleases. The exoribonucleases within this complex are highly conserved and are closely related to prokaryotic ribonuclea
Publikováno v:
Molecular Microbiology. 50:1349-1360
In this paper we show that RNase R is a cold shock protein that is induced seven- to eightfold by cold shock and that its expression is tightly regulated by temperature. Transcriptional studies reveal that the rnr gene is co-transcribed with flanking
Publikováno v:
Molecular Microbiology. 20:1033-1042
Summary PNPase and RNase II are the key regulatory exo-nucleases controlling mRNA decay in Escherichia coli The rnb transcripts were found to proceed through the terminator and PNPase was found to be involved in the 3’to 5’degradation of rnb mRNA
Autor:
Fátima Cairrão, Pedro Domingos
Publikováno v:
eLS
Apoptosis is an intrinsic cell-suicide programme, which ensures tissue homeostasis and safeguards the organism by eliminating unnecessary and unwanted cells, or cells that may constitute some form of danger to the organism, for example, tumour cells.
Autor:
Colin E. McVey, Fátima Cairrão, Célia V. Romão, Cecília M. Arraiano, Maria Arménia Carrondo, Ana Barbas, Carlos Frazão, Ricardo Coelho, Mónica Amblar
Publikováno v:
Acta crystallographica. Section F, Structural biology and crystallization communications. 62(Pt 7)
RNA degradation is important in the post-transcriptional control of gene expression. The processing, degradation and quality control of RNA is performed by many different classes of ribonucleases. Ribonuclease II (RNase II) is a 643-amino-acid enzyme