Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Fábio Pittella-Silva"'
Autor:
Amandda Évelin Silva-Carvalho, Luma Dayane Carvalho Filiú-Braga, Gabriela Muller Reche Bogéa, Alan Jhones Barbosa de Assis, Fábio Pittella-Silva, Felipe Saldanha-Araujo
Publikováno v:
Cancer Cell International, Vol 24, Iss 1, Pp 1-14 (2024)
Abstract Histone methyltransferases (HMTs) are enzymes that regulate histone methylation and play an important role in controlling transcription by altering the chromatin structure. Aberrant activation of HMTs has been widely reported in certain type
Externí odkaz:
https://doaj.org/article/c2cb0ec651f545f39c00b7acc7b4f161
Autor:
Tales Henrique Andrade da Mota, Ana Flávia Reis Guimarães, Amandda Évelin Silva de Carvalho, Felipe Saldanha- de Araujo, Giselle Pinto de Faria Lopes, Fábio Pittella-Silva, Doralina do Amaral Rabello, Diêgo Madureira de Oliveira
Publikováno v:
Repositório Institucional da UnB
Universidade de Brasília (UnB)
instacron:UNB
Universidade de Brasília (UnB)
instacron:UNB
BACKGROUND: The inhibition of the enzyme telomerase (TERT) has been widely investigated as a new pharmacological approach for cancer treatment, but its real potential and the biochemical consequences are not totally understood. OBJECTIVE: Here, we in
Autor:
Claudia C. Gatto, Cássia de Q. O. Cavalcante, Francielle C. Lima, Érica C. M. Nascimento, João B. L. Martins, Brunna L. O. Santana, Ana C. M. Gualberto, Fabio Pittella-Silva
Publikováno v:
Molecules, Vol 29, Iss 12, p 2759 (2024)
The current article reports the investigation of three new Ni(II) complexes with ONS-donor dithiocarbazate ligands: [Ni(L1)PPh3] (1), [Ni(L2)PPh3] (2), and [Ni(L2)Py] (3). Single-crystal X-ray analyses revealed mononuclear complexes with a distorted
Externí odkaz:
https://doaj.org/article/ca63981e1910438f9a7b45a9ef9c2df9
Autor:
Brunna Letícia Olivera Santana, Mariana Braccialli de Loyola, Ana Cristina Moura Gualberto, Fabio Pittella-Silva
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6097 (2024)
SMYD4 is a member of the SMYD family that has lysine methyltransferase function. Little is known about the roles of SMYD4 in cancer. The aim of this study is to investigate genetic alterations in the SMYD4 gene across the most prevalent solid tumors
Externí odkaz:
https://doaj.org/article/f7e10ad8f1f94247bf37ba7f1f1974a7
Autor:
Alan Jhones Barbosa Assis, Brunna Letícia de Oliveira Santana, Ana Cristina Moura Gualberto, Fabio Pittella-Silva
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Acute Lymphoblastic Leukemia (ALL) is the predominant hematological malignancy in pediatric populations, originating from B- or T-cell precursors within the bone marrow. The disease exhibits a high degree of heterogeneity, both at the molecular level
Externí odkaz:
https://doaj.org/article/75e5be9540044ffbb3b9c067e18f0553
Autor:
Juliana, Carvalho Alves-Silva, Doralina, do Amaral Rabello, Martha, Oliveira Bravo, Antônio, Lucena-Araujo, Diego, Madureira de Oliveira, Fábio, Morato de Oliveira, Eduardo, Magalhaes Rego, Fábio, Pittella-Silva, Felipe, Saldanha-Araujo
Publikováno v:
Environmental and molecular mutagenesis. 58(9)
Chromosomal alterations are commonly detected in patients with chronic lymphocytic leukemia (CLL) and impact disease pathogenesis, prognosis, and progression. Telomerase expression (hTERT), its activity and the telomere length are other important pre
Autor:
Cássia de Q. O. Cavalcante, Tales H. A. da Mota, Diêgo M. de Oliveira, Érica C. M. Nascimento, João B. L. Martins, Fabio Pittella-Silva, Claudia C. Gatto
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
In the search for new metal complexes with antitumor potential, two dithiocarbazate ligands derived from 1,1,1-trifluoro-2,4-pentanedione (H2L1) and (H2L2) and four Ni(II) complexes, [Ni(L1)PPh3] (1), [Ni(L1)Py] (2), [Ni(L2)PPh3] (3), and [Ni(L2)Py]
Externí odkaz:
https://doaj.org/article/beacccfcadd54069b775edbb33e99a4b
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2023)
Externí odkaz:
https://doaj.org/article/710430c85b2c483eb54103549e9dd2c0
Autor:
Jerusa Araújo Quintão Arantes, Faria, Natássia Caroline Resende, Corrêa, Carolina, de Andrade, Ana Carolina, de Angelis Campos, Rubens, Dos Santos Samuel de Almeida, Thiago Souza, Rodrigues, Alfredo Miranda, de Goes, Dawidson Assis, Gomes, Fábio Pittella, Silva
Publikováno v:
Journal of cancer science & therapy
Cancer is comprised of a multitude of epigenetic abnormalities, including the global loss and regional gain of DNA methylation as well as alterations in histone methylation. Here, we characterize a new methyltransferase, SET domain-containing protein
Autor:
Tales Henrique Andrade da Mota, Ricardo Camargo, Estefânia Rodrigues Biojone, Ana Flávia Reis Guimarães, Fabio Pittella-Silva, Diêgo Madureira de Oliveira
Publikováno v:
Genes, Vol 14, Iss 3, p 691 (2023)
Telomeres and telomerase are closely linked to uncontrolled cellular proliferation, immortalization and carcinogenesis. Telomerase has been largely studied in the context of cancer, including leukemias. Deregulation of human telomerase gene hTERT is
Externí odkaz:
https://doaj.org/article/45e885b80d7448dd8145619b46607e2a