Výsledky vyhledávání - "Fábio M. Luz"

4-Trichloroacetyl-1,2,3-triazoles: A versatile building block for rapid assessment of carbohydrazides and rufinamide derivatives

Autor: Melissa B. Rodrigues, Marcos A. P. Martins, Helio G. Bonacorso, Nilo Zanatta, Fábio M. Luz, Maiara C. Moraes, Francieli M. Libero, Susiane Cavinatto, Felipe S. Stefanello

Publikováno v: Tetrahedron Letters. 58:3827-3830

This work reports the synthesis of a series of (1H-1,2,3-triazol-4-yl)carbohydrazides (2), which were obtained from 4-trichloroacetyl-1H-1,2,3-triazoles (1). Triazoles 1 were synthesized by 1,3-dipolar cycloaddition reaction, starting from 4-alkoxy-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::43113eba8aba89a9cc5dd8d523ee7138
https://doi.org/10.1016/j.tetlet.2017.08.049

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New solventless and metal-free synthesis of the antiepileptic drug 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide (Rufinamide) and analogues

Autor: Maiara C. Moraes, Fábio M. Luz, Pedro S. Quintana, Helio G. Bonacorso, Nilo Zanatta, Marcos A. P. Martins

Publikováno v: Tetrahedron Letters. 56:441-444

This work presents a new synthesis of the antiepileptic drug rufinamide—1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide) in chemical form—and some analogue compounds, through a one-pot reaction employing a solventless, metal-free catalysis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0fab20adc9e09877b2408c376b69be39
https://doi.org/10.1016/j.tetlet.2014.11.125

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Synthesis of 1H-1,2,3-triazoles—Rufinamide analogs by 1,3-dipolar cycloaddition and eletrocyclization reactions of trifluoroacetyl enolethers under thermal solventless conditions

Autor: Maiara C. Moraes, Alexandre R. Meyer, Fábio M. Luz, Helio G. Bonacorso, Carson W. Wiethan, Marcos A. P. Martins, Nilo Zanatta

Publikováno v: Journal of Fluorine Chemistry. 156:112-119

This paper describes an efficient method for synthesis of rufinamide analogs from the 1,3-dipolar cycloaddition and/or electrocyclization reactions under conventional thermal conditions of 4-alkyl(aryl/heteroaryl)-4-alkoxy-1,1,1-trifluoroalk-3-en-2-o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4450e89a594a3d77d258d99a3d87f79c
https://doi.org/10.1016/j.jfluchem.2013.09.005

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Easy and regioselective access to dimethyl acetal-protected heterocycles and their efficient allylation reactions mediated by allylaluminum reagent

Autor: Nilo Zanatta, Liliane M. F. Porte, Chaiene R. Belo, Marcos A. P. Martins, Maiara C. Moraes, Carson W. Wiethan, Helio G. Bonacorso, Jussara Navarini, Fábio M. Luz

Publikováno v: ResearcherID
ARKIVOC, Vol 2013, Iss 4, Pp 291-305 (2013)

This paper describes easy access to twelve examples of five- and six-membered heterocycles (monocyclic and fused) containing a dimethyl acetal aldehyde function and/or a trifluoromethyl substituent, in good to excellent yields (72-98%). The dimethyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5421dd4bc56edebd62ab6240caf070ab
https://doi.org/10.3998/ark.5550190.p008.164

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Straightforward method for regioselective reduction of 3-acyl-substituted 2-(trifluoromethyl)-2H-chromen-5-one and chromane scaffolds in NaBH4/ethanol medium

Autor: Jussara Navarini, Nilo Zanatta, Helio G. Bonacorso, Carson W. Whietan, Fábio M. Luz, Andrizia F. Junges, Susiane Cavinatto, Marcos A. P. Martins

Publikováno v: Journal of Fluorine Chemistry. 146:53-58

This paper describes a mild method for regioselective reduction of 3-acyl-4-aryl-2-(trifluoromethyl)-2-hydroxy-3,4,7,8-tetrahydro-2 H -chromen-5(6 H )-ones, where acyl = Ac, Bz, 2-thenoyl; and aryl = Ph, 4-NO 2 C 6 H 4 , 4-OCH 3 C 6 H 4; employing so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d9c3d1b4c7137d0c3246dd86dd3bbf37
https://doi.org/10.1016/j.jfluchem.2013.01.007

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β-Alkoxyvinyl trifluoromethyl ketones as efficient precursors for the one-pot synthesis of bis-(4,5-dihydro-1H-pyrazol-1-yl)methanones and 1H-pyrazolyl-1-carbohydrazides

Autor: Cleber A. Cechinel, Helio G. Bonacorso, Nilo Zanatta, Fábio M. Luz, Marcos A. P. Martins, Ronan C. Sehnem, Everton D. Deon

Publikováno v: Arkivoc. 2009:174-182

The one-pot and regioselective synthesis of a novel series of 3-aryl(heteroaryl)-5trifluoromethyl-5-hydroxy-4,5-dihydro-1H-pyrazolyl-1-carbohydrazides and bis-(3-aryl-5trifluoromethyl-5-hydroxy-4,5-dihydro-1H-pyrazol-1-yl)methanones from the cyclocon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dde42cf287f4ec33e158c22642827b5d
https://doi.org/10.3998/ark.5550190.0010.218

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Chemoselective fluorination of 2-hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-ones using DAST

Autor: Carson W. Whietan, Gisele R. Paim, Lenon M. Oliveira, Nilo Zanatta, Liliane M. F. Porte, Helio G. Bonacorso, Fábio M. Luz, Jussara Navarini, Marcos A. P. Martins

Publikováno v: Tetrahedron Letters. 52(26):3333-3335

In this study, diethylaminosulfur trifluoride (DAST) was successfully applied in monofluorination reactions of some trifluoromethyl substituted 2-hydroxy-2H-chromenones, employing a general, mild, and efficient methodology. The fluorinated compounds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a57444b86e62f7bdfa222f22acd4a64

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General method for dehydration, intramolecular cyclization, and fluorination of trifluoromethyl-1H-pyrazoles using DAST

Autor: Gisele R. Paim, Fábio M. Luz, Marcos A. P. Martins, Liliane M. F. Porte, Helio G. Bonacorso, Nilo Zanatta

Publikováno v: Tetrahedron Letters. 51:3759-3761

In this study, the versatile diethylaminosulfur trifluoride (DAST), a well-known fluorinating agent, was applied in the dehydration, intramolecular cyclization, and mono- and difluorination reactions of some 5-trifluoromethyl-1H-pyrazoles and 2-pyraz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e665d479815de1d0752c9650bab91688
https://doi.org/10.1016/j.tetlet.2010.05.052

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