Antibodies as Snakebite Antivenoms: Past and Future

Autor: Wilmar Dias da Silva, Sonia A. De Andrade, Ângela Alice Amadeu Megale, Daniel Alexandre De Souza, Osvaldo Augusto Sant’Anna, Fábio Carlos Magnoli, Felipe Raimondi Guidolin, Kemily Stephanie Godoi, Lucas Yuri Saladini, Patrick Jack Spencer, Fernanda Calheta Vieira Portaro

Publikováno v: Toxins, Vol 14, Iss 9, p 606 (2022)

Snakebite envenomation is considered a neglected tropical disease, affecting tens of thousands of people each year. The recommended treatment is the use of antivenom, which is composed of immunoglobulins or immunoglobulin fragments obtained from the

Externí odkaz: https://doaj.org/article/605280e763be432dbf575c5f3d970262

Quality of horse F(ab’)2 antitoxins and anti-rabies immunoglobulins: protein content and anticomplementary activity

Autor: Carla Cristina Squaiella-Baptistão, Fábio Carlos Magnoli, José Roberto Marcelino, Osvaldo Augusto Sant’Anna, Denise V. Tambourgi

Publikováno v: Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 24, Iss 1, Pp 1-9 (2018)

Abstract Background Among other applications, immunotherapy is used for the post-exposure treatment and/or prophylaxis of important infectious diseases, such as botulism, diphtheria, tetanus and rabies. The effectiveness of serum therapy is widely pr

Externí odkaz: https://doaj.org/article/6896a71139eb47d3920af02096241ae7

Development of IgY antibodies against anti-snake toxins endowed with highly lethal neutralizing activity

Autor: Jorge Hernandez Fernandez, Fábio Carlos Magnoli, David Gitirana da Rocha, Cláudia Maria Costa de Almeida, Wilmar Dias da Silva, Claudia Letícia da Silva, Osmair Élder da Silva

Publikováno v: European Journal of Pharmaceutical Sciences. 106:404-412

Snakebite envenoming is a major neglected disease related to poverty in developing countries. Treatment involves the administration of a specific antivenom serum and auxiliary therapies, if necessary. The improvement of antibodies is of great importa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3c0921640f5827e429b6ffa1c5a0294
https://doi.org/10.1016/j.ejps.2017.05.069

Kn-Ba: a novel serine protease isolated from Bitis arietans snake venom with fibrinogenolytic and kinin-releasing activities

Autor: Fábio Carlos Magnoli, Leo Kei Iwai, Wilmar Dias da Silva, Fernanda C. V. Portaro, Alexandre Kazuo Kuniyoshi, Denise V. Tambourgi, Ângela Alice Amadeu Megale

Publikováno v: Journal of Venomous Animals and Toxins including Tropical Diseases v.24 2018
The Journal of venomous animals and toxins including tropical diseases
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 24, Iss 1, Pp 1-11 (2018)

Background: Bitis arietans is a venomous snake found in sub-Saharan Africa and in parts of Morocco and Saudi Arabia. The envenomation is characterized by local and systemic reactions including pain, blistering, edema and tissue damage, besides hemost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb30c293ff1220c4389e9fa6c28d5c45
https://doi.org/10.1186/s40409-018-0176-5

The complementarity-determining region sequences in IgY antivenom hypervariable regions

Autor: Fábio Carlos Magnoli, Osmair Élder da Silva, Claudia Letícia da Silva, Jorge Hernandez Fernandez, Wilmar Dias da Silva, Cláudia Maria Costa de Almeida, David Gitirana da Rocha

Publikováno v: Data in Brief
Data in Brief, Vol 13, Iss, Pp 717-722 (2017)

The data presented in this article are related to the research article entitled ''Development of IgY antibodies against anti-snake toxins endowed with highly lethal neutralizing activity'' (da Rocha et al., 2017) [1]. Complementarity-determining regi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3296c2725c7aab6b220ef051552a49e9
https://pubmed.ncbi.nlm.nih.gov/28748206