Zobrazeno 1 - 10
of 1 375
pro vyhledávání: '"F, Wirth"'
Autor:
Yaye D. Ndiaye, Wesley Wong, Julie Thwing, Stephen F. Schaffner, Katelyn Vendrely Brenneman, Abdoulaye Tine, Mamadou A. Diallo, Awa B. Deme, Mouhamad Sy, Amy K. Bei, Alphonse B. Thiaw, Rachel Daniels, Tolla Ndiaye, Amy Gaye, Ibrahima M. Ndiaye, Mariama Toure, Nogaye Gadiaga, Aita Sene, Djiby Sow, Mamane N. Garba, Mamadou S. Yade, Baba Dieye, Khadim Diongue, Daba Zoumarou, Aliou Ndiaye, Jules F. Gomis, Fatou B. Fall, Medoune Ndiop, Ibrahima Diallo, Doudou Sene, Bronwyn Macinnis, Mame C. Seck, Mouhamadou Ndiaye, Bassirou Ngom, Younouss Diedhiou, Amadou M. Mbaye, Lamine Ndiaye, Ngayo Sy, Aida S. Badiane, Daniel L. Hartl, Dyann F. Wirth, Sarah K. Volkman, Daouda Ndiaye
Publikováno v:
Malaria Journal, Vol 23, Iss 1, Pp 1-14 (2024)
Abstract Background Drug resistance in Plasmodium falciparum is a major threat to malaria control efforts. Pathogen genomic surveillance could be invaluable for monitoring current and emerging parasite drug resistance. Methods Data from two decades (
Externí odkaz:
https://doaj.org/article/8a5f3909d06b4f5d84805dad88419345
Autor:
Wesley Wong, Stephen F. Schaffner, Julie Thwing, Mame Cheikh Seck, Jules Gomis, Younouss Diedhiou, Ngayo Sy, Medoune Ndiop, Fatou Ba, Ibrahima Diallo, Doudou Sene, Mamadou Alpha Diallo, Yaye Die Ndiaye, Mouhamad Sy, Aita Sene, Djiby Sow, Baba Dieye, Abdoulaye Tine, Jessica Ribado, Joshua Suresh, Albert Lee, Katherine E. Battle, Joshua L. Proctor, Caitlin A. Bever, Bronwyn MacInnis, Daouda Ndiaye, Daniel L. Hartl, Dyann F. Wirth, Sarah K. Volkman
Publikováno v:
Malaria Journal, Vol 23, Iss 1, Pp 1-13 (2024)
Abstract Background Genetic surveillance of the Plasmodium falciparum parasite shows great promise for helping National Malaria Control Programmes (NMCPs) assess parasite transmission. Genetic metrics such as the frequency of polygenomic (multiple st
Externí odkaz:
https://doaj.org/article/5608145da9cd4c09a5c64e5e6c7f65e0
Autor:
Stephen F. Schaffner, Aida Badiane, Akanksha Khorgade, Medoune Ndiop, Jules Gomis, Wesley Wong, Yaye Die Ndiaye, Younouss Diedhiou, Julie Thwing, Mame Cheikh Seck, Angela Early, Mouhamad Sy, Awa Deme, Mamadou Alpha Diallo, Ngayo Sy, Aita Sene, Tolla Ndiaye, Djiby Sow, Baba Dieye, Ibrahima Mbaye Ndiaye, Amy Gaye, Aliou Ndiaye, Katherine E. Battle, Joshua L. Proctor, Caitlin Bever, Fatou Ba Fall, Ibrahima Diallo, Seynabou Gaye, Doudou Sene, Daniel L. Hartl, Dyann F. Wirth, Bronwyn MacInnis, Daouda Ndiaye, Sarah K. Volkman
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-11 (2023)
Abstract We here analyze data from the first year of an ongoing nationwide program of genetic surveillance of Plasmodium falciparum parasites in Senegal. The analysis is based on 1097 samples collected at health facilities during passive malaria case
Externí odkaz:
https://doaj.org/article/af5251c51419409ba360e17d7f160b1e
Autor:
Selina Bopp, Charisse Flerida A. Pasaje, Robert L. Summers, Pamela Magistrado-Coxen, Kyra A. Schindler, Victoriano Corpas-Lopez, Tomas Yeo, Sachel Mok, Sumanta Dey, Sebastian Smick, Armiyaw S. Nasamu, Allison R. Demas, Rachel Milne, Natalie Wiedemar, Victoria Corey, Maria De Gracia Gomez-Lorenzo, Virginia Franco, Angela M. Early, Amanda K. Lukens, Danny Milner, Jeremy Furtado, Francisco-Javier Gamo, Elizabeth A. Winzeler, Sarah K. Volkman, Maëlle Duffey, Benoît Laleu, David A. Fidock, Susan Wyllie, Jacquin C. Niles, Dyann F. Wirth
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Drug resistance to current antimalarials is rising and new drugs and targets are urgently needed. Here the authors identify Plasmodium falciparum acyl-CoA synthetase 10 as a new target whose inhibition leads to a decrease in triacylglycerols.
Externí odkaz:
https://doaj.org/article/8ae40ec50bdc468aaa960a15e9ca87b3
Autor:
Rebecca EK Mandt, Madeline R Luth, Mark A Tye, Ralph Mazitschek, Sabine Ottilie, Elizabeth A Winzeler, Maria Jose Lafuente-Monasterio, Francisco Javier Gamo, Dyann F Wirth, Amanda K Lukens
Publikováno v:
eLife, Vol 12 (2023)
Drug resistance remains a major obstacle to malaria control and eradication efforts, necessitating the development of novel therapeutic strategies to treat this disease. Drug combinations based on collateral sensitivity, wherein resistance to one dru
Externí odkaz:
https://doaj.org/article/0401791b59174b2ea135e6bcfac22ca9
Autor:
Mark A. Tye, N. Connor Payne, Catrine Johansson, Kritika Singh, Sofia A. Santos, Lọla Fagbami, Akansha Pant, Kayla Sylvester, Madeline R. Luth, Sofia Marques, Malcolm Whitman, Maria M. Mota, Elizabeth A. Winzeler, Amanda K. Lukens, Emily R. Derbyshire, Udo Oppermann, Dyann F. Wirth, Ralph Mazitschek
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The development of antimalarials against the human liver and asexual blood stages is one of the top public health challenges. Here, the authors report a single-step biochemical assay for the characterization of prolyl-tRNA synthetase inhibitors, and
Externí odkaz:
https://doaj.org/article/67e7e347e61b426e9ad816c4a19d8f56
Autor:
Miranda K. Dziobak, Brian C. Balmer, Randall S. Wells, Emily C. Pisarski, Ed F. Wirth, Leslie B. Hart
Publikováno v:
Oceans, Vol 3, Iss 3, Pp 231-249 (2022)
Phthalates are endocrine-disrupting chemicals added to plastics, personal care products, cleaning solutions, and pesticides. Extensive use has led to its exposure to wildlife, including common bottlenose dolphins (Tursiops truncatus) from Sarasota Ba
Externí odkaz:
https://doaj.org/article/db284a21833241bea4b1301cd7a53607
Autor:
Sabine Ottilie, Madeline R. Luth, Erich Hellemann, Gregory M. Goldgof, Eddy Vigil, Prianka Kumar, Andrea L. Cheung, Miranda Song, Karla P. Godinez-Macias, Krypton Carolino, Jennifer Yang, Gisel Lopez, Matthew Abraham, Maureen Tarsio, Emmanuelle LeBlanc, Luke Whitesell, Jake Schenken, Felicia Gunawan, Reysha Patel, Joshua Smith, Melissa S. Love, Roy M. Williams, Case W. McNamara, William H. Gerwick, Trey Ideker, Yo Suzuki, Dyann F. Wirth, Amanda K. Lukens, Patricia M. Kane, Leah E. Cowen, Jacob D. Durrant, Elizabeth A. Winzeler
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Ottilie et al. employ an experimental evolution approach to investigate the role of transcription factors in yeast chemical resistance. Most emergent mutations in resistant strains were enriched in transcription factor coding genes, highlighting thei
Externí odkaz:
https://doaj.org/article/9094da31e4444ec8861d9e3850fe0c08
Autor:
Mouhamad Sy, Awa B. Deme, Joshua L. Warren, Angela Early, Stephen Schaffner, Rachel F. Daniels, Baba Dieye, Ibrahima Mbaye Ndiaye, Younous Diedhiou, Amadou Moctar Mbaye, Sarah K. Volkman, Daniel L. Hartl, Dyann F. Wirth, Daouda Ndiaye, Amy K. Bei
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Molecular epidemiology using genomic data can help identify relationships between malaria parasite population structure, malaria transmission intensity, and ultimately help generate actionable data to assess the effectiveness of malaria cont
Externí odkaz:
https://doaj.org/article/3a8c22e8d2cc409784772b8df269919c
Autor:
Yaye Die Ndiaye, Daniel L. Hartl, David McGregor, Aida Badiane, Fatou Ba Fall, Rachel F. Daniels, Dyann F. Wirth, Daouda Ndiaye, Sarah K. Volkman
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 17, Iss , Pp 12-22 (2021)
The use of antimalarial drugs is an effective strategy in the fight against malaria. However, selection of drug resistant parasites is a constant threat to the continued use of this approach. Antimalarial drugs are used not only to treat infections b
Externí odkaz:
https://doaj.org/article/8db04926110d4578ab7b8b3b695c46ed