Reliability and minimal clinically important differences of forced vital capacity: Results from the Scleroderma Lung Studies (SLS-I and SLS-II)

Autor: Suzanne Kafaja, Philip J. Clements, Holly Wilhalme, Chi-hong Tseng, Daniel E. Furst, Grace Hyun Kim, Jonathan Goldin, Elizabeth R. Volkmann, Michael D. Roth, Donald P. Tashkin, Dinesh Khanna, Ann Arbor, D. Khanna, Los Angeles, P. J. Clements, D. P. Tashkin, R. Elashoff, J. Goldin, M. Roth, D. Furst, K. Bulpitt, W.-L. J. Chung, S. Viasco, M. Sterz, L. Woolcock, X. Yan, J. Ho, S. Vasunilashorn, I. da Costa, J. R. Seibold, D. J. Riley, J. K. Amorosa, V. M. Hsu, D. A. McCloskey, J. E. Wilson, J. Varga, D. Schraufnagel, A. Wilbur, D. Lapota, S. Arami, P. Cole-Saffold, R. Simms, A. Theodore, P. Clarke, J. Korn, K. Tobin, M. Nuite, R. Silver, M. Bolster, C. Strange, S. Schabel, E. Smith, J. Arnold, K. Caldwell, M. Bonner, R. Wise, F. Wigley, B. White, L. Hummers, M. Bohlman, A. Polito, G. Leatherman, E. Forbes, M. Daniel, V. Steen, C. Read, C. Cooper, S. Wheaton, A. Carey, A. Ortiz, M. Mayes, E. Parsley, S. Oldham, T. Filemon, S. Jordan, M. Perry, null K. Connolly, J. Golden, P. Wolters, R. Webb, J. Davis, C. Antolos, C. Maynetto, B. Fessler, M. Olman, C. Sanders, L. Heck, T. Parkhill, N. Rothfield, M. Metersky, R. Cobb, M. Aberles, F. Ingenito, E. Breen, K. Mubarak, J. L. Granda, J. Silva, Z. Injic, R. Alexander, S. Springmeyer, S. Kirkland, J. Molitor, R. Hinke, A. Mondt, T. Thompson, S. Rounds, M. Weinstein, B. Thompson, H. Paulus, S. Levy, D. Martin, E. Kissin, F. Y. Cheong, G. Marlis, J. Mason-Berry, P. Saffold, M. Rodriguez, L. Guzman, J. Brook, G. Ibrahim, K. Largaespada, C. Fridley, M. Zulmastashvili, A. Manu, S. Moore, F. N. Hant, K. Gibson, M. Morrison, H. Donnelly, C. Marlin, J. Gangar, A. Eller, D. Leong, M. Lalosh, J. Obata, D. Franklin, E. Schiopu, M. Benedict-Blue, V. Leone, J. Shaw, F. Tan, J. Anderson, A. Saulino, P. Carey, M. Esplin, P. Carlson

Publikováno v: American journal of respiratory and critical care medicine. 197(5)

Rationale: FVC percent predicted (FVC%) is the primary outcome measure in clinical trials of systemic sclerosis interstitial lung disease. For interpretation of change in the FVC% over time, it is important to define whether these changes are clinica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f4196559588eeaa282cfc49e0fb9be
https://pubmed.ncbi.nlm.nih.gov/29186664

The Iron-Responsive Fur/RyhB Regulatory Cascade Modulates the Shigella Outer Membrane Protease IcsP

Autor: Helen J. Wing, Amanda F. Wigley, Lia A. Africa, Erin R. Murphy, Nicholas R. Egan

Publikováno v: Infection and Immunity. 79:4543-4549

Actin-based motility is central to the pathogenicity of the intracellular bacterial pathogen Shigella . Two Shigella outer membrane proteins, IcsA and IcsP, are required for efficient actin-based motility in the host cell cytoplasm, and the genes enc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bcbd675bc6313379ee3481584cb6ab1
https://doi.org/10.1128/iai.05340-11

Ash deposition at higher levels of coal replacement by biomass

Autor: Alf Malmgren, Gerry Riley, J. Williamson, F. Wigley

Publikováno v: Fuel Processing Technology. 88:1148-1154

Coal–biomass mixtures have been prepared and combusted on the Imperial College entrained flow reactor (EFR). Five different biomasses were mixed with two bituminous coals at levels of up to 60 wt.%. Samples of deposit have been collected and charac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7f4416554b65083c43f30e60e0b7e4ef
https://doi.org/10.1016/j.fuproc.2007.06.015

HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cells

Autor: Volker Blank, Nathan E. Welty, Amanda F. Wigley, Karen E. Iles, Dale A. Dickinson, Henry Jay Forman

Publikováno v: Free Radical Biology and Medicine. 39:355-364

Heme oxygenase-1 (HO-1) is a key cytoprotective enzyme and an established marker of oxidative stress. Increased HO-1 expression has been found in the resident macrophages in the alveolar spaces of smokers. The lipid peroxidation product 4-hydroxynone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd1a87d49ee527cf9f0fd7df0e5f1be1
https://doi.org/10.1016/j.freeradbiomed.2005.03.026

The relationship between excluded mineral matter and the abrasion index of a coal

Autor: J.J. Wells, F. Wigley, J. Williamson, D.J. Foster, W.H. Gibb

Publikováno v: Fuel. 83:359-364

Predictions of the wear rates of components in grinding mills at pulverised coal-fired power stations are currently made using empirical relationships based on the ash content of the coals. However, modern coal characterisation techniques now allow t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::89c2b51311d0d9759ff9cd79c3f1374e
https://doi.org/10.1016/s0016-2361(03)00262-x