Zobrazeno 1 - 10
of 1 354
pro vyhledávání: '"F, Van Leuven"'
Publikováno v:
Genomics [Genomics] 1999 May 15; Vol. 58 (1), pp. 111.
Publikováno v:
Genomics. 58(1)
Akademický článek
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Autor:
I. Dewachter, L. Ris, T. Jaworski, C.M. Seymour, A. Kremer, P. Borghgraef, H. De Vijver, E. Godaux, F. Van Leuven
Publikováno v:
Neurobiology of Disease, Vol 35, Iss 2, Pp 193-200 (2009)
Accumulating evidence implicates deregulation of GSK3ß as a converging pathological event in Alzheimer's disease and in neuropsychiatric disorders, including bipolar disorder and schizophrenia. Although these neurological disorders share cognitive d
Externí odkaz:
https://doaj.org/article/32ff4496717740bb91a94b5488e3814b
Autor:
R. Nuydens, G. Van Den Kieboom, C. Nolten, C. Verhulst, P. Van Osta, K. Spittaels, C. Van den Haute, E. De Feyter, H. Geerts, F. Van Leuven
Publikováno v:
Neurobiology of Disease, Vol 9, Iss 1, Pp 38-48 (2002)
Coexpression of constitutively active GSK-3β[S9A] rescued the axonal pathology induced by overexpression of human tau in transgenic mice (Spittaels et al., (2000) J. Biol. Chem. 275, 41340–41349). We isolated dorsal root ganglion (DRG) neuronal cu
Externí odkaz:
https://doaj.org/article/634bf00584894df29d80bbf4c038cd48
Autor:
C. Van den Haute, K. Spittaels, J. Van Dorpe, R. Lasrado, K. Vandezande, I. Laenen, H. Geerts, F. Van Leuven
Publikováno v:
Neurobiology of Disease, Vol 8, Iss 1, Pp 32-44 (2001)
The potential contribution of cyclin-dependent protein kinase 5 (cdk5) to hyperphosphorylate protein tau, as claimed in Alzheimer's disease, was investigated in vivo. We generated single, double, and triple transgenic mice that coexpress human cdk5 a
Externí odkaz:
https://doaj.org/article/57c33427603946329a79138dbac401df
Publikováno v:
Journal of Lipid Research, Vol 36, Iss 8, Pp 1774-1786 (1995)
The expression of the proteinase inhibitors of the alpha-macroglobulin family and of their clearance receptor was analyzed in the mouse during pregnancy, embryonal development, and adolescence. In total we studied seven partners of a complicated netw
Externí odkaz:
https://doaj.org/article/20aceeec24b5499cb8b258010493223d
Autor:
Anneke Kremer, Saak V. Ovsepian, Mario M. Dorostkar, G Aramuni, F. Van Leuven, Severin Filser, Christian Schön, Simon M. Ochs, Julia Pöschl, Jochen Herms
Publikováno v:
Europe PubMed Central
Molecular psychiatry 20(4), 482-489 (2014). doi:10.1038/mp.2014.55
Molecular Psychiatry
Molecular psychiatry 20(4), 482-489 (2014). doi:10.1038/mp.2014.55
Molecular Psychiatry
Central nervous glycogen synthase kinase 3β (GSK3β) is implicated in a number of neuropsychiatric diseases, such as bipolar disorder, depression, schizophrenia, fragile X syndrome or anxiety disorder. Many drugs employed to treat these conditions i
Autor:
F. Van Leuven, Kim Serdons, Guy Bormans, Alfons Verbruggen, Peter Borghgraef, M. Van Eeckhoudt, Hank F. Kung, Dominique Vanderghinste, T. de Groot
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 52:473-481
Uncharged derivatives of thioflavin-T have known in vitro and in vivo affinity for amyloid β. We synthesized and evaluated two derivatives with a fluorine-18 labelled fluoropropoxy substituent either at the 6-position or at the 2′-position of the
Autor:
Emile Godaux, Laurence Ris, Anneke Kremer, Peter Borghgraef, F. Van Leuven, Claire M. Seymour, Ilse Dewachter, H De Vijver, Tomasz Jaworski
Publikováno v:
Neurobiology of Disease, Vol 35, Iss 2, Pp 193-200 (2009)
Accumulating evidence implicates deregulation of GSK3ss as a converging pathological event in Alzheimer's disease and in neuropsychiatric disorders, including bipolar disorder and schizophrenia. Although these neurological disorders share cognitive d