Characterization of molecular associations involving L-ornithine and α-ketoglutaric acid: crystal structure of L-ornithinium α-ketoglutarate

Autor: Ivo B. Rietveld, René Céolin, Laurence Berthon, F. Tombret, Hassan Allouchi

Publikováno v: Annales Pharmaceutiques Françaises
Annales Pharmaceutiques Françaises, Elsevier Masson, 2014, 72 (4), pp.238-243. 〈10.1016/j.pharma.2014.04.005〉
Annales Pharmaceutiques Françaises, Elsevier Masson, 2014, 72 (4), pp.238-243. ⟨10.1016/j.pharma.2014.04.005⟩

The crystal structure of L-ornithinium α-ketoglutarate (C5H13N2O2, C5H5O5) has been solved by direct methods using single crystal X-ray diffraction data. It crystallizes in the monoclinic system, space group P21, unit cell parameters a=15.4326(3), b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c25c70353bb1e9f0ac5c381732e4d48
https://hal.archives-ouvertes.fr/hal-01123345

ChemInform Abstract: New N-Aryl Isoxazolecarboxamides and N-Isoxazolylbenzamides as Anticonvulsant Agents

Autor: F Lepage, F Tombret, JM Gillardin, G. Cuvier, A. Marivain

Publikováno v: ChemInform. 24

We prepared a series of N-aryl isoxazolecarboxamide, N-isoxazolylbenzamide compounds and derivatives and studied their anticonvulsant action in MES and MMS tests. Some of these reveal considerable activity, especially with respect to MES test. The di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::533d5341ee2132add31fc497e154d20b
https://doi.org/10.1002/chin.199307197

New N-aryl isoxazolecarboxamides and N-isoxazolylbenzamides as anticonvulsant agents

Autor: F Tombret, JM Gillardin, G. Cuvier, A. Marivain, F Lepage

Publikováno v: European Journal of Medicinal Chemistry. 27:581-593

We prepared a series of N-aryl isoxazolecarboxamide, N-isoxazolylbenzamide compounds and derivatives and studied their anticonvulsant action in MES and MMS tests. Some of these reveal considerable activity, especially with respect to MES test. The di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::76de204ebf91590836dd95f8f1c1cfd1
https://doi.org/10.1016/0223-5234(92)90137-p

Metabolic chiral inversion of stiripentol in the rat. I. Mechanistic studies

Autor: K, Zhang, C, Tang, M, Rashed, D, Cui, F, Tombret, H, Botte, F, Lepage, R H, Levy, T A, Baillie

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 22(4)

To study enantioselective aspects of the disposition of stiripentol (STP), a chiral allylic alcohol undergoing development as an antiepileptic drug, a stereoselective synthesis was developed and the configuration of the two enantiomers determined to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bdfdae74fe9c8103175f7b8cb0ed9b8d
https://pubmed.ncbi.nlm.nih.gov/7956728

The metabolic fate of stiripentol in man

Autor: T A, Moreland, J, Astoin, F, Lepage, F, Tombret, R H, Levy, T A, Baillie

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 14(6)

The metabolism of stiripentol (I), a new antiepileptic drug, was studied in healthy human subjects. Following a single 1200-mg oral dose to one subject, 13 metabolites of I were detected in urine and were identified by GC/MS techniques. The structure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4d5fc0403c4e363a2a13a459501b5651
https://pubmed.ncbi.nlm.nih.gov/2877822