Brain accumulation of inhaled uranium in the rat depends on aerosol concentration, exposure repetitions, particle size and solubility

Autor: Benjamin B. Tournier, Philippe Lestaevel, F. Petitot, Chrystelle Ibanez, Isabelle Dublineau, François Paquet, Elie Tourlonias

Publikováno v: Toxicology letters, Vol. 351 (2021) pp. 10-17
Toxicology Letters
Toxicology Letters, Elsevier, 2021, pp.10-17. ⟨10.1016/j.toxlet.2021.08.002⟩
Toxicology Letters, 2021, pp.10-17. ⟨10.1016/j.toxlet.2021.08.002⟩

A rostro-caudal gradient of uranium (U) in the brain has been suggested after its inhalation. To study the factors influencing this mapping, we first used 30-min acute inhalation at 56 mg/m3of the relatively soluble form UO4in the rat. These exposure

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4d15d6105c4032894811434ae5cce91
https://archive-ouverte.unige.ch/unige:155092

In vitro evaluation of percutaneous diffusion of uranyl nitrate through intact or excoriated skin of rat and pig

Autor: François Paquet, F. Petitot, A M. Moreels

Publikováno v: Canadian Journal of Physiology and Pharmacology. 82:133-139

At the present time, the International Commission on Radiological Protection (ICRP) has not published any model concerning internal radioactive contamination by uptake from wounds. The aims of our work were to determine the time available to treat co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7e8194d0c714b17855669f94bef33fa
https://doi.org/10.1139/y04-004

Inhalation of uranium nanoparticles: respiratory tract deposition and translocation to secondary target organs in rats

Autor: Isabelle Dublineau, Philippe Lestaevel, François Gensdarmes, Benjamin B. Tournier, B. Dhieux, F. Petitot, Sébastien Jacquinot, Patricia Beaunier, Charline Mazzucco, Olivia Delissen, Elie Tourlonias

Publikováno v: Toxicology Letters, Vol. 217, No 3 (2013) pp. 217-225
Toxicol Lett.
Toxicol Lett., 2013, 217, pp.217-225. ⟨10.1016/j.toxlet.2012.12.022⟩

International audience; Uranium nanoparticles (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68e6c95a037213e4c751604c36e7cf0
https://archive-ouverte.unige.ch/unige:92574

Evolution of the percutaneous penetration and distribution of uranyl nitrate as a function of skin-barrier integrity: An in vitro assessment

Autor: F. Petitot, François Paquet, Anne-Marie Moreels

Publikováno v: Drug and Chemical Toxicology
Drug and Chemical Toxicology, 2010, 33 (3), pp.316-324. ⟨10.3109/01480540903431457⟩

As recommended by OECD Guidelines, percutaneous penetration studies consider intact skin, but rarely injured skin. Recent years have witnessed a growing concern for these two types of dermal exposure in the industry, particularly in the nuclear indus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b021f3d137162877c05b219b67e385
https://hal.archives-ouvertes.fr/hal-02974259

Discrimination of Radiotoxic and Chemotoxic Effects of Uranium on Mouse Embryo Fibroblasts

Autor: C. Darolles, Isabelle Dublineau, F. Petitot, S. Roch-Lefèvre

Publikováno v: Radioprotection. 43

Uranium (U) is a natural radioactive heavy metal used in the nuclear industry, in different forms with different isotopic compositions (natural, depleted or enriched in 235U) and solubilities. Uranium internal exposure is a major risk for the nuclear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ff0e9f25d2f7a4163b9e1cf2a59f468b
https://doi.org/10.1051/radiopro:2008656