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Merosin and laminin in myogenesis; specific requirement for merosin in myotube stability and survival

Autor: U M Wewer, Pierre H. Vachon, F Loechel, Huaxi Xu, Eva Engvall

Publikováno v: The Journal of Cell Biology

Laminin (laminin-1; alpha 1-beta 1-gamma 1) is known to promote myoblast proliferation, fusion, and myotube formation. Merosin (laminin-2 and -4; alpha 2-beta 1/beta 2-gamma 1) is the predominant laminin variant in skeletal muscle basement membranes;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f870cd03144ff2e7269323e65715e77
https://doi.org/10.1083/jcb.134.6.1483

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Regulation of laminin beta2 chain gene expression in human cancer cell lines

Autor: M E, Durkin, F C, Nielsen, F, Loechel, R, Albrechtsen, U M, Wewer

Publikováno v: European journal of biochemistry. 268(13)

The laminin beta2 chain is a basement membrane component expressed in a tissue- and developmental stage-specific manner. In this report we have examined the transcriptional and post-transcriptional regulation of the human laminin beta2 chain in human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d2a6ff8e4ac188de86b2139be32ee5c8
https://pubmed.ncbi.nlm.nih.gov/11432748

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Immunization with a plasmid expressing pneumococcal surface protein A (PspA) can elicit protection against fatal infection with Streptococcus pneumoniae

Autor: David T. Curiel, Robert M. Conry, T Greenway, Larry S. McDaniel, David E. Briles, C Benedict, F Loechel

Publikováno v: Gene therapy. 4(4)

Pneumococcal surface protein A (PspA) is a protectioneliciting protein of Streptococcus pneumoniae. We observed that immunization of BALB/c mice with a plasmid expressing PspA significantly protected the mice from lethal challenge with S. pneumoniae

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64fbfc36122cb1b4be3d879905dee7b3
https://pubmed.ncbi.nlm.nih.gov/9176525

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A carcinoembryonic antigen polynucleotide vaccine for human clinical use

Autor: R M, Conry, A F, LoBuglio, F, Loechel, S E, Moore, L A, Sumerel, D L, Barlow, J, Pike, D T, Curiel

Publikováno v: Cancer gene therapy. 2(1)

We have constructed a plasmid DNA encoding the full-length complementary DNA for human carcinoembryonic antigen (CEA) under transcriptional regulatory control of the cytomegalovirus early promoter/enhancer (pCEA) and demonstrated that this plasmid ca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7298016e48fbe6da6417a01af5bdbfff
https://pubmed.ncbi.nlm.nih.gov/7621253

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A carcinoembryonic antigen polynucleotide vaccine has in vivo antitumor activity

Autor: R M, Conry, A F, LoBuglio, F, Loechel, S E, Moore, L A, Sumerel, D L, Barlow, D T, Curiel

Publikováno v: Gene therapy. 2(1)

We have constructed a plasmid DNA encoding the full-length cDNA for human carcinoembryonic antigen (CEA) driven by the cytomegalovirus early promoter/enhancer and demonstrated that this plasmid can function as a polynucleotide vaccine. The immune res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9668a9f6bc7e49f2245822cc09d5c228
https://pubmed.ncbi.nlm.nih.gov/7712333

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Intracellular single-chain antibody directed against erbB2 down-regulates cell surface erbB2 and exhibits a selective anti-proliferative effect in erbB2 overexpressing cancer cell lines

Autor: J, Deshane, F, Loechel, R M, Conry, G P, Siegal, C R, King, D T, Curiel

Publikováno v: Gene therapy. 1(5)

Overexpression of the tyrosine kinase receptor erbB2 is important in the pathogenesis of a variety of neoplasms. Based on this concept, targeted anti-cancer strategies have been designed to selectively eradicate erbB2 overexpressing tumor cells. Thes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d108c27df0b3a50e25d0116157a9b363
https://pubmed.ncbi.nlm.nih.gov/7584099

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Immune response to a carcinoembryonic antigen polynucleotide vaccine

Autor: R M, Conry, A F, LoBuglio, J, Kantor, J, Schlom, F, Loechel, S E, Moore, L A, Sumerel, D L, Barlow, S, Abrams, D T, Curiel

Publikováno v: Cancer research. 54(5)

We have constructed a DNA plasmid encoding the full length complementary DNA for human carcinoembryonic antigen (CEA) driven by the cytomegalovirus early promoter/enhancer (plasmid DNA encoding human CEA) and demonstrated that this plasmid can functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::4b6d837c58095e6c27453be4dd4b0aa1
https://pubmed.ncbi.nlm.nih.gov/8118800

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