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Roles of insulin, guanosine 5′-[γ-thio]triphosphate and phorbol 12-myristate 13-acetate in signalling pathways of GLUT4 translocation

Autor: M. Todaka, Narito Morii, Takanobu Imanaka, S. Kamohara, Shuh Narumiya, Kazuhiro Kishi, Motoaki Shichiri, Yasumasa Mitani, Yousuke Ebina, F Kanai, Hideki Hayashi, Keisuke Tamaoka

Publikováno v: Scopus-Elsevier

Insulin, guanosine 5´-[γ-thio]triphospate (GTP[S]) and phorbol 12-myristate 13-acetate (PMA) trigger the translocation of GLUT4 (type 4 glucose transporter; insulin-sensitive glucose transporter) from an intracellular pool to the cell surface. We h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f468d9093c1f4ee0bc983871fa6e6ea2
https://doi.org/10.1042/bj3150875

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Frequency of Mutations of Insulin Receptor Gene in Japanese Patients With NIDDM

Autor: Yousuke Ebina, Naotake Hashimoto, Takashi Murakami, Hiroyuki Sano, F Kanai, Masaharu Kan, M. Todaka, Mitsuru Iida, Hideaki Jinnouchi, S. Kamohara, Takanobu Imanaka, Hideichi Makino, Sho Yoshida, Tetsuo Ohnishi, Kimio Ito, Yasuhiko Nishioka, Susumu Kagawa, Hideki Hayashi

Publikováno v: Diabetes. 44:1081-1086

To examine the prevalence of abnormalities in the insulin receptor structure gene in Japanese Patients with non-insulin-dependent diabetes mellitus (NIDDM), a population of 51 patients with NIDDM was screened for mutations in this gene. Patient genom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9822065cfa653e1e37537fd6dd24569e
https://doi.org/10.2337/diab.44.9.1081

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The role of insulin in activation of two enhancers in the mouse GLUT1 gene

Autor: F Kanai, M. Todaka, Satomi Saito, Hideki Hayashi, Takashi Murakami, M Shichiri, K. Ito, Kazuo Ishii, T Nishiyama, Masaharu Kan

Publikováno v: Journal of Biological Chemistry. 269:29265-29270

We identified two enhancer elements of the mouse GLUT1 gene responsive to serum, growth factor, and oncogenes; the first enhancer element (enhancer-1) is located 2.7 kilobases upstream of the cap site of the gene, and the second one (enhancer-2) is l

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1479a4ae8e1ecaa8a2b33924123735
https://doi.org/10.1016/s0021-9258(19)62040-5

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Adenovirus-mediated drug-sensitivity gene therapy for hepatocellular carcinoma

Autor: F, Kanai, M, Ohashi, P A, Marignani, Y, Shiratori, H, Hamada, M, Omata

Publikováno v: Methods in molecular medicine. 45

Selective gene therapy represents a potent approach in cancer treatment that utilizes a cell's own nontoxic suicide genes. Currently, the suicide genes under investigation mediate sensitivity by encoding viral or bacterial enzymes that convert inacti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6a6a123bf8365db9c3be5d2e599ac26c
https://pubmed.ncbi.nlm.nih.gov/21341063

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Direct demonstration of insulin-induced GLUT4 translocation to the surface of intact cells by insertion of a c-myc epitope into an exofacial GLUT4 domain

Autor: M. Todaka, F Kanai, Hideki Hayashi, S. Kamohara, Yousuke Ebina, Yasuhiko Nishioka

Publikováno v: Scopus-Elsevier

Stimulation of glucose transport is the main physiological effect of insulin in target tissues. This effect is linked to translocation of the GLUT4 glucose transporter from an intracellular pool to the cell surface. To elucidate the molecular mechani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b55c1135ab674aea9489d4af364359ed
https://doi.org/10.1016/s0021-9258(19)85269-9

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Insulin treatment stimulates the tyrosine phosphorylation of the alpha-type 85-kDa subunit of phosphatidylinositol 3-kinase in vivo

Autor: N Miyake, F Shibasaki, S. Kamohara, T Takenawa, Hideki Hayashi, Yousuke Ebina, Yasuhiko Nishioka, Yoshihiro Fukui, F Kanai

Publikováno v: Journal of Biological Chemistry. 267:22575-22580

After adding insulin to cells overexpressing the insulin receptor, the activity of phosphatidylinositol (PI) 3-kinase in the anti-phosphotyrosine immunoprecipitates was rapidly and greatly increased. This enzyme may therefore be a substrate for the i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5ea959a23ab91ade64c9eb9932ebe08
https://doi.org/10.1016/s0021-9258(18)41711-5

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Phosphorylation in vitro of the 85 kDa subunit of phosphatidylinositol 3-kinase and its possible activation by insulin receptor tyrosine kinase

Autor: F Kanai, Hideki Hayashi, N Miyake, Yousuke Ebina, F Shibasaki, T Takenawa

Publikováno v: Biochemical Journal. 280:769-775

Insulin causes a dramatic and rapid increase in phosphatidylinositol 3-kinase activity in the anti-phosphotyrosine immunoprecipitates of cells overexpressing the human insulin receptor. This enzyme may therefore be a mediator of insulin signal transd

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fdee4e39f58f61c0b2462a6b7117a75
https://doi.org/10.1042/bj2800769

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A cluster of four Sp1 binding sites required for efficient expression of the human insulin receptor gene

Autor: F Kanai, Yasuo Shinohara, Masataka Mori, Eiichi Araki, Fumio Shimada, Yousuke Ebina, Tetsuya Shirotani, Motoaki Shichiri, Takashi Murakami

Publikováno v: Journal of Biological Chemistry. 266:3944-3948

Fragments of 5'-flanking sequences of the human insulin receptor gene were analyzed in transient expression assays after transfection of cell lines with expression assays after transfection of cell lines with an improved low background chloramphenico

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65656723813d96ae516b47c48220999c
https://doi.org/10.1016/s0021-9258(19)67884-1

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