Zobrazeno 1 - 10
of 2 136
pro vyhledávání: '"F, Hughes"'
Autor:
Oonagh C. Lyons, Maeve A. Kerr, Mary A. T. Flynn, Leane Hoey, Catherine F. Hughes, Aoife Caffrey, Eamon Laird, Katie Moore, Kirsty M. Porter, Conal Cunningham, Kevin McCarroll, Anne M. Molloy, Fergal Tracey, Maurice O’Kane, J. J. Strain, Mary Ward, Helene McNulty
Publikováno v:
Diabetology & Metabolic Syndrome, Vol 16, Iss 1, Pp 1-18 (2024)
Abstract Background Nutrition is recognized as playing an important role in the metabolic syndrome (MetS), but the dietary components involved are unclear. We aimed to investigate nutrition factors in relation to MetS and its progression in older adu
Externí odkaz:
https://doaj.org/article/ae7632d2ded349deaaea9b75e4b4a165
Autor:
Helene Damhofer, Tülin Tatar, Benjamin Southgate, Scott Scarneo, Karl Agger, Daria Shlyueva, Lene Uhrbom, Gillian M. Morrison, Philip F. Hughes, Timothy Haystead, Steven M. Pollard, Kristian Helin
Publikováno v:
Cell Death and Disease, Vol 15, Iss 4, Pp 1-17 (2024)
Abstract Poor survival and lack of treatment response in glioblastoma (GBM) is attributed to the persistence of glioma stem cells (GSCs). To identify novel therapeutic approaches, we performed CRISPR/Cas9 knockout screens and discovered TGFβ activat
Externí odkaz:
https://doaj.org/article/9c882069fd714df8a02c424b20d4f84c
Autor:
Peter D. Hibbert, Charlotte J. Molloy, Ian D. Cameron, Leonard C. Gray, Richard L. Reed, Louise K. Wiles, Johanna Westbrook, Gaston Arnolda, Rebecca Bilton, Ruby Ash, Andrew Georgiou, Alison Kitson, Clifford F. Hughes, Susan J. Gordon, Rebecca J. Mitchell, Frances Rapport, Carole Estabrooks, Gregory L. Alexander, Charles Vincent, Adrian Edwards, Andrew Carson-Stevens, Cordula Wagner, Brendan McCormack, Jeffrey Braithwaite
Publikováno v:
BMC Medicine, Vol 22, Iss 1, Pp 1-15 (2024)
Abstract Background This study estimated the prevalence of evidence-based care received by a population-based sample of Australian residents in long-term care (LTC) aged ≥ 65 years in 2021, measured by adherence to clinical practice guideline (CPG)
Externí odkaz:
https://doaj.org/article/08cb650470204549ac984048f4b07f7c
Autor:
Alyssah Ahern, Daniel F. Hughes
Publikováno v:
PeerJ, Vol 12, p e17209 (2024)
Changes to biodiversity from urbanization are occurring worldwide, and baseline data is vital to document the magnitude and direction of these alterations. We set out to document the biodiversity of an urban lake in Eastern Iowa that was devoid of ba
Externí odkaz:
https://doaj.org/article/7c86f5e1838c4579ac95baa04ace3806
Autor:
Nicola F. Hughes, Lorna A. Fern, Angela Polanco, Chris Carrigan, Richard G. Feltbower, Ashley Gamble, Emily Connearn, Angela Lopez, Ellen Bisci, Kathy Pritchard-Jones
Publikováno v:
Research Involvement and Engagement, Vol 9, Iss 1, Pp 1-10 (2023)
Abstract Background In the United Kingdom, healthcare data is collected on all patients receiving National Health Service (NHS) care, including children and young people (CYP) with cancer. This data is used to inform service delivery, and with specia
Externí odkaz:
https://doaj.org/article/53466b6c26124434bd51a50e0aed3e96
Autor:
Adrianna K. San Roman, Helen Skaletsky, Alexander K. Godfrey, Neha V. Bokil, Levi Teitz, Isani Singh, Laura V. Blanton, Daniel W. Bellott, Tatyana Pyntikova, Julian Lange, Natalia Koutseva, Jennifer F. Hughes, Laura Brown, Sidaly Phou, Ashley Buscetta, Paul Kruszka, Nicole Banks, Amalia Dutra, Evgenia Pak, Patricia C. Lasutschinkow, Colleen Keen, Shanlee M. Davis, Angela E. Lin, Nicole R. Tartaglia, Carole Samango-Sprouse, Maximilian Muenke, David C. Page
Publikováno v:
Cell Genomics, Vol 4, Iss 1, Pp 100462- (2024)
Summary: Somatic cells of human males and females have 45 chromosomes in common, including the “active” X chromosome. In males the 46th chromosome is a Y; in females it is an “inactive” X (Xi). Through linear modeling of autosomal gene expres
Externí odkaz:
https://doaj.org/article/f7bcee4c14104a018d0e1ee125035ddd
Autor:
Ricky Nathvani, Sierra N. Clark, Emily Muller, Abosede S. Alli, James E. Bennett, James Nimo, Josephine Bedford Moses, Solomon Baah, A. Barbara Metzler, Michael Brauer, Esra Suel, Allison F. Hughes, Theo Rashid, Emily Gemmell, Simon Moulds, Jill Baumgartner, Mireille Toledano, Ernest Agyemang, George Owusu, Samuel Agyei-Mensah, Raphael E. Arku, Majid Ezzati
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract The urban environment influences human health, safety and wellbeing. Cities in Africa are growing faster than other regions but have limited data to guide urban planning and policies. Our aim was to use smart sensing and analytics to charact
Externí odkaz:
https://doaj.org/article/c87f25fc035e4ae297131f4949aec374
Autor:
Jiayuan Wang, Abosede S Alli, Sierra N Clark, Majid Ezzati, Michael Brauer, Allison F Hughes, James Nimo, Josephine Bedford Moses, Solomon Baah, Ricky Nathvani, Vishwanath D, Samuel Agyei-Mensah, Jill Baumgartner, James E Bennett, Raphael E Arku
Publikováno v:
Environmental Research Letters, Vol 19, Iss 3, p 034036 (2024)
Road traffic has become the leading source of air pollution in fast-growing sub-Saharan African cities. Yet, there is a dearth of robust city-wide data for understanding space-time variations and inequalities in combustion related emissions and expos
Externí odkaz:
https://doaj.org/article/229f385b899542d08b4ef772ae8a8dd3
Autor:
Aero Renyer, Krishna Ravindra, Barbara A. Wetmore, Jermaine L. Ford, Michael DeVito, Michael F. Hughes, Leah C. Wehmas, Denise K. MacMillan
Publikováno v:
Toxics, Vol 11, Iss 12, p 951 (2023)
Few studies are available on the environmental and toxicological effects of perfluoroalkyl ether carboxylic acids (PFECAs), such as GenX, which are replacing legacy PFAS in manufacturing processes. To collect initial data on the toxicity and toxicoki
Externí odkaz:
https://doaj.org/article/f755faf0b693462dbddd645d9ae1fec7
Autor:
Scott A. Scarneo, Aaron P. Smith, Jacob Favret, Robert O’Connell, Joy Pickeral, Kelly W. Yang, Guido Ferrari, David R. Loiselle, Philip F. Hughes, Manjusha M. Kulkarni, Madhusudhana Gargesha, Bryan Scott, Debashish Roy, Barton F. Haynes, Jesse J. Kwiek, Timothy A. J. Haystead
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Heat shock protein 90 (Hsp90) maintains cellular proteostasis during stress and has been under investigation as a therapeutic target in cancer for over two decades. We and others have identified a membrane expressed form of Hsp90 (mHsp90) th
Externí odkaz:
https://doaj.org/article/7498fd35bf0d43599a354d885b957978